A5037289486- Malaria Research and Control
- Trypanosoma species research and implications
- Drug-Induced Hepatotoxicity and Protection
- Mosquito-borne diseases and control
- Hemoglobinopathies and Related Disorders
- HIV Research and Treatment
- Complement system in diseases
- Viral Infections and Vectors
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Vector-borne infectious diseases
- Hepatitis C virus research
- Research on Leishmaniasis Studies
- Hepatitis B Virus Studies
Institut Pasteur du Cambodge
2023-2025
Centre Pasteur du Cameroun
2021-2023
Université de Strasbourg
2021
Inserm
2021
Centre National de la Recherche Scientifique
2021
Modèles Insectes de l'Immunité Innée
2021
Summary Background The WHO malaria treatment guidelines recommend a total dose in the range of 3·5 to 7·0 mg/kg primaquine eliminate Plasmodium vivax ( P. ) hypnozoites and prevent relapses. There are however indications that for tropical isolates, notably from Southeast Asia, lower is insufficient. Determining most effective regimen needed achieve elimination this parasite. Methods We conducted an open-label randomised controlled trial Kampong Speu province, Western Cambodia. infected...
Most malaria-endemic countries, including Cambodia, use a total dose of 3·5 mg/kg primaquine to eliminate Plasmodium vivax hypnozoites and prevent relapses. There are, however, indications that the lower is insufficient for tropical P isolates, particularly in southeast Asia, WHO now recommends 7·0 most countries. We aimed determine effective regimen support elimination efforts this malaria parasite. conducted an open-label, randomised controlled trial Kampong Speu province, western...
Malaria control relies on passive case detection, and this strategy fails detecting asymptomatic infections. In addition, infections in endemic areas harbor multiple parasite genotypes that could affect management malaria epidemiology.
Invasion of erythrocytes by members the Plasmodium genus is an essential step parasite lifecycle, orchestrated numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms PCRCR complex which binds basigin on erythrocyte surface. Rh5 restricted to its close relatives; however, PTRAMP, CSS Ripr orthologs are present across genus. We investigated from three species elucidate common features complex. Like falciparum, PTRAMP form a disulfide-linked...
<title>Abstract</title> Invasion of erythrocytes by members the Plasmodium genus is an essential step parasite lifecycle, orchestrated numerous host-parasite interactions. In P. falciparum Rh5, with PfCyRPA, PfRipr, PfCSS, and PfPTRAMP, forms PCRCR complex which binds basigin on erythrocyte surface. Rh5 restricted to its close relatives; however, PTRAMP, CSS Ripr orthologs are present across genus. We investigated from three species elucidate common features complex. Like falciparum, PTRAMP...
The spread of Plasmodium falciparum resistant parasites remains one the major challenges for malaria control and elimination in Sub Saharan Africa. Monitoring molecular markers conferring resistance to different antimalarials is important track optimize therapeutic lifespan current drugs. This study aimed evaluate prevalence known mutations drug genes Pfcrt , Pfmdr1 Pfdhfr Pfdhps two epidemiological settings Cameroon. Dried blood spots collected 2018 2019 from asymptomatic individuals were...
Abstract Background Malaria remains a serious public health problem in Cameroon. Implementation of control interventions requires prior knowledge the local epidemiological situation. Here we report results and entomological surveys carried out Tibati, Adamawa Region, Cameroon, an area where malaria transmission is seasonal, 6 years after introduction long-lasting insecticidal bed nets. Methods Cross-sectional studies were July 2015 2017 Tibati. Thick blood smears dried spots collected from...
Sickle cell trait (SCT) refers to the carriage of one abnormal copy β-globin gene, HbS allele. SCT offers protection against malaria, controlling parasite density and preventing progression symptomatic malaria. However, it remains unclear whether also affects transmission stages mosquito infection parameters. Deciphering impact on human malaria is key understanding mechanisms that maintain in endemic areas.The study was conducted from June July 2017 among asymptomatic children living...
Abstract Background Plasmodium vivax has been more resistant to various control measures than falciparum malaria because of its greater transmissibility and ability produce latent parasite forms. Therefore, developing P. vaccines therapeutic monoclonal antibodies (humAbs) remains a high priority. The Duffy antigen receptor for chemokines (DARC) expressed on erythrocytes is central invasion reticulocytes. expresses binding protein (PvDBP) merozoites, DARC ligand, the DARC: PvDBP interaction...
Abstract New therapeutics are a priority for preventing and eliminating Plasmodium vivax (Pv) malaria because of its easy transmissibility dormant stages in the liver. Relapses due to liver major contributor reoccurring Pv. Therefore, therapies that reduce establishment parasites blood-stage infection important controlling this geographically widespread parasite. Here, we isolated 12 human monoclonal antibodies (humAbs) from plasma Pv-exposed individual recognized Pv apical membrane antigen...
New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy transmissibility and dormancy in the liver that increases clinical burden recurrent relapse. We isolated 12 Pv Apical Membrane Antigen 1 (PvAMA1) specific human monoclonal antibodies from Peripheral Blood Mononuclear Cells of a exposed individual. PvAMA1 is essential sporozoite merozoite invasion, making it unique therapeutic target. HumAb 826827 blocked invasion erythrocytes using isolates inhibited...
Plasmodium vivax is the most widespread of different species able to infect humans and responsible for malaria cases outside Africa. An effective, strain-transcending vaccine that alleviates or suppresses erythrocyte invasion would be a game-changer in eliminating malaria. Recently, binding P. Reticulocyte Binding Protein 2b (PvRBP2b) human Transferrin receptor (TfR1) has been described as essential reticulocyte invasion, making this parasite protein an appealing candidate. Here, using...
Abstract New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy transmissibility and dormancy in the liver that increases clinical burden recurrent relapse. In this manuscript we characterize 12 Pv Apical Membrane Antigen 1 (PvAMA1) specific human monoclonal antibodies from Peripheral Blood Mononuclear Cells of a Pv-exposed individual. PvAMA1 is essential sporozoite merozoite invasion, making it unique therapeutic target. We show humAb 826827 blocks invasion...
An amendment to this paper has been published and can be accessed via the original article.