A5028279029- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Cholinesterase and Neurodegenerative Diseases
- Zebrafish Biomedical Research Applications
- Neurotransmitter Receptor Influence on Behavior
- Drug Transport and Resistance Mechanisms
- Health, Nursing, Elderly Care
- Protein Structure and Dynamics
- Olfactory and Sensory Function Studies
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects and Toxicity Studies
- Nicotinic Acetylcholine Receptors Study
- Adipose Tissue and Metabolism
- Mast cells and histamine
- Aging, Elder Care, and Social Issues
- Hypothalamic control of reproductive hormones
Pontifícia Universidade Católica do Rio Grande do Sul
2016-2025
Instituto do Cérebro
2009-2025
Universidade Federal do Rio de Janeiro
2019-2022
National Council for Scientific and Technological Development
2009-2020
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2013
Significance The hippocampus and basolateral amygdala—modulated by β-noradrenergic, D1/D5 dopaminergic, H2-histaminergic receptors—control memory processing of many memories, but their role in social recognition (SRM) has been little studied. SRM is fundamental for the establishment relationships and, consequently, formation stability groups. deficits psychiatric disorders, such as autism schizophrenia, are believed to be caused alterations amygdala. Here we examine involvement amygdala—and...
Significance Within a restricted time window, brief exposure to novel environment enhances the extinction of contextual fear. This can be explained by hippocampal process behaviorally induced synaptic tagging and capture. Here, we report that effect requires glutamate NMDA receptors L-voltage–dependent calcium channels involves activation calcium/calmodulin-dependent protein kinase II, in addition both ribosomal nonribosomal synthesis. All these mechanisms operate only when...
Extinction is the learned inhibition of retrieval. Recently it was shown that a brief exposure to novel environment enhances extinction contextual fear in rats, an effect explainable by synaptic tagging-and-capture process. Here we examine whether this also happens with another fear-motivated task, inhibitory avoidance (IA), and depends on dopamine acting D1 or D5 receptors. Rats were trained first IA then task. The retention measured 24 h later. A 5-min 30 min before training enhanced its...
Alzheimer's disease (AD) causes dementia and memory loss in the elderly. Deposits of beta-amyloid peptide hyperphosphorylated tau protein are present a brain with AD. A filtrate Helicobacter pylori's culture was previously found to induce hyperphosphorylation vivo, suggesting that bacterial exotoxins could permeate blood-brain barrier directly tau's phosphorylation. H. pylori, which infects ~60% world population gastritis gastric cancer, produces pro-inflammatory urease (HPU). Here,...
The nitric oxide (NO)/soluble guanylyl cyclase (sGC)/protein kinase G (PKG) pathway is important for memory processing, but the identity of its downstream effectors as well actual participation in consolidation nonaversive declarative long-term (LTM) remain unknown. Here, we show that training rats an object recognition (OR) learning task rapidly increased nitrites/nitrates (NOx) content CA1 region dorsal hippocampus while posttraining intra-CA1 microinfusion neuronal NO synthase (nNOS)...
Significance Integrity of the brain histaminergic system is necessary for long-term memory (LTM) but not short-term step-down inhibitory avoidance (IA). Histamine depletion in hippocampus or basolateral amygdala (BLA) impairs LTM that task. infusion into either structure restores histamine-depleted rats. The restoring effect BLA occurs even when hippocampal activity was impaired. Cyclic adenosine monophosphate (cAMP) responsive-element-binding protein phosphorylation correlates anatomically...
Significance Blockade of the retrieval contextual fear conditioning by intrahippocampal muscimol administration does not impede extinction task measured up to 1 wk later, its eventual spontaneous recovery at 14 d, or inhibition two different protein synthesis inhibitors given into hippocampus. These results show that and are separate processes strongly suggest is triggered gated conditioned stimulus even in absence retrieval.
Significance Several neurotransmitters contribute to memory formation by modulating selectively acquisition, consolidation, and/or retrieval. Integrity of the brain histamine system is necessary for consolidation inhibitory avoidance (IA) memory. Here, we report that cerebral depletion also impairs retrieval IA in rats and blunts retrieval-induced c-Fos activation cAMP-responsive element binding protein phosphorylation CA1 region hippocampus. Histamine infusion into restores...
Significance Disruption of memories stressful events may trigger maladaptive responses that are distinctive features obsessive-compulsive disorders, phobias, posttraumatic stress disorder (PTSD), and generalized anxiety. Drugs available to alleviate these disorders have minimal or inconsistent efficacy. The gold standard treatment, exposure therapy, is based on extinction, which refers a new memory trace inhibiting original retrieval. As not all patients experience beneficial effects this...
This preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointestinal (GI) tract rats using positron emission tomography (PET) following oral administration [18F]MC225. Different protocols were evaluated, radioactivity uptake was compared with intravenous administration. Twelve male Wistar divided into four groups subjected to or [18F]MC225 protocols: G1 (intravenous route), G2 (oral without fasting), G3 G4 fasting P-gp inhibitor...
Concerns over the replicability and reproducibility of published research have grown in many fields, but empirical data to inform policies are still scarce. Biomedical Brazil expanded rapidly last three decades, with no systematic assessment its findings. With this mind, we set up Brazilian Reproducibility Initiative, a multicenter replication experiments from science using common experimental methods: MTT assay, reverse transcription polymerase chain reaction (RT-PCR) elevated plus maze...
ABSTRACT Permeability‐glycoprotein (P‐gp), a crucial efflux pump transporter encoded by the ABCB1 gene, plays pivotal role in drug disposition at blood–brain barrier (BBB) and is involved pharmacokinetics of numerous therapeutic agents. This study investigates differences P‐gp function BBB between males females cohort older (55+) healthy volunteers (HV) using [ 18 F]MC225 PET. Twenty HV (11 9 females), free from medications that affect without history neurological or psychiatric disorders,...