A5013692289- Biochemical Analysis and Sensing Techniques
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Cancer Mechanisms and Therapy
- Olfactory and Sensory Function Studies
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Dermatology and Skin Diseases
- Bioinformatics and Genomic Networks
- Ginseng Biological Effects and Applications
- Biochemical effects in animals
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Coronary Artery Anomalies
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Kawasaki Disease and Coronary Complications
Nanjing University of Chinese Medicine
2017-2022
Suzhou Traditional Chinese Medicine Hospital
2016-2022
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‑related deaths among cancer patients. Genes correlated with progression and prognosis HCC are critically needed to be identified. In present study, 3 Gene Expression Omnibus (GEO) datasets (GSE46408, GSE65372 GSE84402) were used analyze differentially expressed genes (DEGs) between non‑tumor liver tissues. Ontology (GO) Kyoto Encyclopedia Genomes (KEGG) enrichment analyses conducted clarify functional roles DEGs. A...
Our previous research suggests that 3-deoxyglucosone (3DG), formed in the caramelization course and Maillard reactions food, is an independent factor for development of prediabetes. Since relationship between type 2 diabetes (T2D) intestinal microbiota moving from correlation to causality, we investigated alterations composition function 3DG-induced prediabetic rats. Rats were given 50 mg/kg 3DG by intragastric administration two weeks. Microbial profiling faeces samples was determined...
The tumor immunological microenvironment in hepatocellular carcinoma (HCC) is the T‐helper (Th) 2 dominant inhibition state. Improving immunosuppressive represents an important strategy for HCC treatment. TSLP‐OX40L pathway a target to improve Th2 immunosuppression. Yupingfeng granule (YPF) clinically used effectively immune status of HCC. In this study, YPF increased percentage mature dendritic cells (DCs) and decreased levels TSLP, TSLPR, OX40L adjacent tissues orthotopic‐HCC mice model....
Our recent findings support the idea that 3-deoxyglucosone (3DG), a dietary composition, has been suggested as an independent factor for development of prediabetes. Secretion glucagon-like peptide-1 (GLP-1) to be impaired in T2DM and conditions associated with hyperglycemia. Since low oral bioavailability 3DG indicated single administration study, present study we examined if is capable accumulating intestinal tissue rats after 2-week 3DG, treatment affects GLP-1 secretion glucose...
3-Deoxyglucosone (3DG), a highly reactive dicarbonyl intermediate generated during glycation, has been confirmed to be markedly elevated in the plasma of patients with diabetes. Our previous study found that there is an association between increasing accumulation 3DG and impaired glucose regulation non-diabetic seniors (females, >50 years old; males, >55 old). It was also led homeostasis healthy mice, however, mechanisms underlying deleterious effect diabetes remain fully elucidated. The...
Secretion of glucagon-like peptide-1 has been suggested to be impaired in T2DM and conditions associated with hyperglycemia. 3-Deoxyglucosone, a dietary composition, as an independent factor for the development prediabetes. A-pathophysiological very high condition 3DG concentrations administered i. v. induced acute glucose intolerance rats. In this study, examine effects single intragastric administration at dose potentially single-meal intake on plasma glucose, insulin, glucagon, total...
Background . Clinically, Yu ping feng san (YPFS) has been extensively used as a medication for treating immune deficiency, and YPFS is combined with chemotherapy drugs to treat cancer, including hepatocellular carcinoma (HCC), lung pancreatic cancer. Previous research shown that therapeutic effect on HCC by improving the immunosuppressive state of liver cancer microenvironment. The present study aimed investigate angiogenesis HCC. Methods High-performance liquid chromatography (HPLC) was...
Sweet taste receptors (STRs) involve in regulating the release of glucose-stimulated glucagon-like peptide-1 (GLP-1). Our vivo and vitro studies found that 3-deoxyglucosone (3DG) inhibited GLP-1 secretion.This study investigated role STRs 3DG-induced inhibition high secretion.STC-1 cells were incubated with lactisole or 3DG for 1 h under 25 mM glucose conditions. Western blotting was used to expression signaling molecules ELISA analyse cyclic adenosine monophosphate (cAMP) levels.Lactisole...
A recent study found an increased level of 3DG during oral glucose load in healthy individuals, which redirects our attention to the effect high plasma pathophysiology type 2 diabetes mellitus. We previously that abnormally elevated was significantly associated with impaired regulation non-diabetic seniors. The current aimed investigate acute effects exogenous on levels, tolerance and insulin levels. significant increase observed rats administrated 50 mg/kg i. v. even h after. With elevation...
Kawasaki disease (KD) causes acute systemic vasculitis and has unknown etiology. Since the stage of KD is most relevant, aim present study was to identify hub genes in by bioinformatics analysis. We also aimed at constructing microRNA (miRNA)–messenger RNA (mRNA) regulatory networks associated with based on previously identified differentially expressed miRNAs (DE-miRNAs). DE-mRNAs patients were screened using mRNA expression profile data GSE18606 from Gene Expression Omnibus. The functional...
Type 2 diabetes (T2D) is a major global public health burden, with β-cell dysfunction key component in its pathogenesis. However, the exact pathogenesis of T2D yet to be fully elucidated. Ferroptosis, recently discovered regulated form non-apoptotic cell death, plays vital role development and complications. The current study aimed identify molecules involved ferroptosis3 patients using mRNA expression profile data GSE25724 by bioinformatic approaches. differentially expressed mRNAs...
β‑cell dysfunction is the primary cause of type 2 diabetes mellitus (T2DM). 1,2‑dicarbonyl compounds, such as 3‑deoxyglucosone (3DG) have been reported to increase risk T2DM. Abnormal elevation plasma 3DG may impair function and thereby, it linked Previous findings suggest that exogenous serve an important role in development pre‑diabetes. In present study, authors examine whether induces impaired glucose regulation mice by decreasing involving accumulation 3DG. At two weeks following...
Glucose triggers glucagon-like peptide (GLP)-1 secretion from L cells involving several glucose sensors including sodium-glucose transporter (SGLT)1, (GLUT)2, and sweet taste receptors (STRs). This study investigated the effects of different concentrations on GLP-1 secretion, intracellular Ca2+ cAMP, uptake, protein levels SGLT1, GLUT2, STRs in STC-1 cells. Low (5.6 mM) increased concentration, SGLT1 level compared with glucose-free group. concentration triggered by low were inhibited...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. The nuclear factor activated T cells (NFAT) family implicated in tumorigenesis and progression various types cancer. However, little known about their expression patterns, distinct prognostic values, potential regulatory networks NSCLC. In this study, we comprehensively analyzed value NFATs NSCLC through large databases, including Oncomine, UCSC Xena Browser, UALCAN Kaplan-Meier Plotter, cBioPortal,...
3-Deoxyglucosone (3DG) is derived from D-glucose during food processing and storage under physiological conditions. We reported that glucagon-like peptide-1 (GLP-1) secretion in response to an oral glucose load vivo high-glucose stimulation vitro was decreased by acute 3DG administration. In this study, we determined the effect of on GLP-1 basal conditions investigated possible mechanisms. Normal fasting rats were given a single intragastric administration 50 mg/kg 3DG. Plasma levels...
Sweet taste receptors (STRs) expressed on β‑cells stimulate insulin secretion in response to an increase the circulating level of glucose, maintaining glucose homeostasis. 3‑Deoxyglucosone (3DG), a highly reactive α‑dicarbonyl compound, has been previously described as independent factor associate with development prediabetes. In our previous study, pathological plasma levels 3DG were induced normal rats single intravenous injection 50 mg/kg 3DG, and acute rise intolerance by impairing...
Sodium glucose co-transporter 1 (SGLT1) triggers low glucose-induced glucagon-like peptide-1 (GLP-1) secretion. We reported that a two-week administration of 3-deoxyglucosone (3DG), an independent factor associated with the development pre-diabetes, reduces basal GLP-1 secretion in rats.This study investigated effects 3DG on and SGLT1 pathway under low-glucose conditions STC-1 cells.STC-1 cells were incubated phloridzin or at 5.6 mM glucose. expression (by western blotting), cyclic adenosine...