A5083468232- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Boron and Carbon Nanomaterials Research
- Supramolecular Self-Assembly in Materials
- Fullerene Chemistry and Applications
- Molecular Sensors and Ion Detection
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Extracellular vesicles in disease
- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Organoboron and organosilicon chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Protein purification and stability
- Photoacoustic and Ultrasonic Imaging
- Cancer Research and Treatments
Hiroshima University
2019-2025
Suzugamine Women's College
2023
Kyoto University
2016-2021
RIKEN Center for Sustainable Resource Science
2019-2021
Graduate School USA
2019-2020
Higashihiroshima Medical Center
2020
Japan Science and Technology Agency
2016-2017
Kyoto Katsura Hospital
2016
Surface polymer engineering was applied with a carrier of exosomes, namely, the amphiphilic cationic CHP (cCHP) nanogel, to improve delivery exosome content by forming complexes exosomes.
Benzo[ d ]dithieno[ b , f ]borepins exhibited reddish room-temperature phosphorescence (RTP) despite the absence of heavy atoms and oxygen atoms.
Abstract Protein pharmaceuticals show great therapeutic promise, but effective intracellular delivery remains challenging. To address the need for efficient protein transduction systems, we used a magnetic nanogel chaperone (MC): hybrid of polysaccharide nanogel, carrier with molecular chaperone‐like properties, and iron oxide nanoparticles, enabling magnetically guided delivery. The MC complexed model proteins, such as BSA insulin, was not cytotoxic. Cargo proteins were delivered to target...
A calcium (Ca)-deficient hydroxyapatite was investigated for its potential to remove Sr2+ from environmentally relevant water. We conducted sorption tests on solutions containing magnesium ion (Mg2+) and (Ca2+) as competing cations at a strontium (Sr2+) concentration of 0.05 mmol/L. The Ca-deficient maintained high ratio above 80% in the presence Mg2+ Ca2+ concentrations between 0.1 1.0 mmol/L, whereas stoichiometric showed lower even small amounts (72% 51% mmol/L). For with various 0.01 10...
Various cells in vivo secrete exosomes consisting of lipid bilayers. They carry mRNAs and miRNAs capable controlling cellular functions can be used as drug delivery system nanocarriers. There is the current need to further improve efficiency exosome uptake into target cells. In this study, we prepared a hybrid magnetic nanoparticles, which could guided by field for efficient uptake. Magnetic nanogels were hybridized fluorescently labeled isolated from PC12 By applying with nanogel,...
Abstract Fermented plant product (FPP) is a dietary supplement made by fermentation and aging of variety plants, including fruits, vegetables, grains. A previous study has shown that oral FPP supplementation prevents the development allergic rhinitis-like nasal symptoms in murine model Japanese cedar pollinosis without affecting systemic immune response. However, mode action which exerts an anti-allergic effect remains to be elucidated. Here, we show acts on mast cells suppress immediate...
Developing straightforward and efficient methods for incorporating functional hydrophobic guest molecules into lipid membranes is essential the application of liposomes as drug delivery systems. In a previous study, we reported preparation lipid‐membrane‐incorporated C60, C60 derivatives, C70 (LMICx) through host‐exchange method, wherein these were transferred from γ‐cyclodextrin to liposomes. this applied similar approach prepare porphyrins (LMIPors), transferring polysaccharides However,...
With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most promising candidates for cancer treatment. Here, we developed a facile self-assembled nanogel using photosensitizer-grafted polysaccharides called chlorin e6-bearing pullulan. Chlorin e6 used as photosensitizer in therapy. The anti-cancer effect with our system was 780 times higher than that commercially available Photofrin. Finally, demonstrated actively growing cell spheroids can be...
The development of boron agents with integrated functionality, including biocompatibility, high content, and cancer cell targeting, is desired to exploit the therapeutic efficacy neutron capture therapy (BNCT). Here, we report BNCT using a HER-2-targeted antibody-conjugated nitride nanotube/β-1,3-glucan complex. anticancer effect our system was 30-fold that clinically available agent l-BPA/fructose
With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most elegant strategies for achieving effective tumor therapy. Herein, a facile preparation thermal process-triggered release water-soluble photosensitizer 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (THPP) has been developed using thermoresponsive polysaccharide, hydroxypropyl cellulose. Current systems cellulose enable manipulation loading capacity THPP into polymer matrix size complex by...
Developing photoactivatable theranostic platforms with integrated functionalities of biocompatibility, targeting, imaging contrast, and therapy is a promising approach for cancer diagnosis therapy. Here, we report agent based on hybrid nanoparticle comprising fullerene nanocrystals gold nanoparticles (FGNPs) photoacoustic photothermal Compared to crystals, FGNPs exhibited stronger signals heating characteristics by irradiating light an optimal wavelength. Our studies demonstrated that could...
β-(1,3-1,6)-D-Glucan, λ-carrageenan, tamarind gum, and pullulan can dissolve various porphyrin derivatives via the formation of complexes in water using a high-speed vibration milling method. The aqueous solutions resulting exhibit long-term stability. Despite adverse effects self-quenching process, notable fluorescence improved photodynamic activity polysaccharide-complexed were observed presence liposomes, micelles, cyclodextrins, HeLa cells. It was noted that type porphyrins more...
Chlorins with phenol units were dissolved in water via complexation the solubilizing agents trimethyl-β-cyclodextrin and λ-carrageenan using a high-speed vibration milling technique. The photodynamic activities of (TMeβCD) complexes similar to that Photofrin. However, chlorin more stable aqueous solutions than TMeβCD-chlorin complexes. Thus, λ-carrageenan-complexed would be suitable as photosensitizer.
TMe-β-CDx-complexed porphyrins with hydroxyphenyl moieties in the <italic>meso</italic>-position showed higher photodynamic activities than dihydroxyphenyl and injected a dimethyl sulfoxide solution.
DNA-free genome editing using Cas9 ribonucleoprotein is advantageous because it introduces fewer potential undesirable genetic modifications than comparable methods. Here, we show a direct protein delivery system for plants cell-penetrating peptide-displayed polyion complex vesicle, CPP-PICsome, as biological nanocarrier. With this system, demonstrate nuclear by of in Arabidopsis thaliana callus.
With their low immunogenicity and excellent deliverability, extracellular vesicles (EVs) are promising platforms for drug delivery systems. In this study, hydrophobic molecule loading techniques were developed via an exchange reaction based on supramolecular chemistry without using organic solvents that can induce EV disruption harmful side effects. To demonstrate the availability of exchanging to prepare drug-loading EVs, boron cluster carborane (CB) was introduced EVs (CB@EVs), which is...
With its minimal invasiveness, photodynamic therapy (PDT) is considered one of the most elegant modalities in cancer treatment. In this study, a facile hybrid nanoparticle was developed, composed upconversion nanoparticles and chlorin e6-bearing pullulan, which can serve as photosensitizer activated by near-infrared red laser. Cell death induction cells achieved through energy transfer from laser emitted to e6. The therapeutic efficacy our system surpassed that clinically available...
Abstract 5,15‐Diazaporphyrins, which have a large absorption at wavelengths over 600 nm, were dissolved in water by complex formation with β‐(1,3‐1,6)‐ d ‐glucans. Aqueous solutions of these complexes relatively stable compared their trimethyl‐β‐cyclodextrin‐complexed analogues. β‐Glucan‐complexed diazaporphyrins showed quenched fluorescence and had low singlet‐oxygen‐generation abilities owing to random self‐aggregation. However, external stimuli, such as the presence liposomes or...
A dyad system comprising a lipid membrane-incorporated fullerene derivative with an N,N-dimethylpyrrodinium group (C60-1) and photoantenna molecule (DiD) did not exhibit the high photodynamic activity expected based on its singlet oxygen generation ability. Comparison amide substituent (C60-2) suggested cause to be that some of had been released from liposomes, partly disrupting system. The C60-2 DiD exhibited about twice toward HeLa cells as C60-1 DiD, due suppression release liposomes....
Chitosan is a natural polysaccharide with the advantageous qualities of biocompatibility and biodegradability, it has recently been spotlighted as soft material for sustainable society. Advantages such these are in demand application various biomaterials. Although extensive studies have conducted on preparation chitosan films, overcoming problems weak mechanical properties remains significant barrier. In present study, we developed stretchable doxorubicin-loaded biocompatible films by adding...
Naphthalenediimide derivative-absorbed papers had fluorescence intensity and maximum depending on the type of guest aromatic molecules after exposure to vapors small 10 molecules. Furthermore, showed a mechanochromic property.
Tetrakis(4-aminophenyl)porphyrin (1) and tetrakis(4-acetamidophenyl)porphyrin (2) were dissolved in water with the incorporation of a polysaccharide (λ-carrageenan (CGN)) as water-solubilizing agent. Although photodynamic activity CGN-2 complex was considerably lower than that CGN-1 complex, selectivity index (SI; IC50 normal cell/IC50 cancer cell) higher complex. This is because significantly affected by intracellular uptakes cells. During vivo experiments, inhibited tumor growth under...
Boron neutron capture therapy (BNCT) is a promising modality for cancer treatment because of its minimal invasiveness. To maximize the therapeutic benefits BNCT, development efficient platforms delivery boron agents indispensable. Here, carborane-integrated immunoliposomes were prepared via an exchanging reaction to achieve HER-2-targeted BNCT. The conjugation anti-HER-2 antibody liposomes successfully endowed these with targeting properties toward HER-2-overexpressing human ovarian cells...