A5029654866- Marine Toxins and Detection Methods
- Marine Invertebrate Physiology and Ecology
- Nicotinic Acetylcholine Receptors Study
- Environmental Chemistry and Analysis
- Marine and coastal ecosystems
- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Pesticide Residue Analysis and Safety
- Toxic Organic Pollutants Impact
- Analytical chemistry methods development
- Environmental Toxicology and Ecotoxicology
- Neurological Disease Mechanisms and Treatments
- Isotope Analysis in Ecology
- Analytical Methods in Pharmaceuticals
- Microbial Community Ecology and Physiology
- Insect behavior and control techniques
- Vibrio bacteria research studies
- Insect Utilization and Effects
- Analytical Chemistry and Chromatography
- Marine Sponges and Natural Products
- Paraquat toxicity studies and treatments
- Marine Ecology and Invasive Species
- Marine Biology and Environmental Chemistry
- Amino Acid Enzymes and Metabolism
- Insect Pest Control Strategies
National Research Council Canada
2011-2025
National Academies of Sciences, Engineering, and Medicine
2014
Institute for Marine Biosciences
2011
Main text The CCQM-K148.b comparison, undertaken with a parallel pilot study CCQM-P187.b, was coordinated by the BIPM and UME on behalf of Consultative Committee for Amount Substance: Metrology in Chemistry Biology (CCQM) Working Group Organic Analysis (OAWG). It National Measurement Institutes (NMIs) Designated (DIs) which provide measurement services organic analysis under CIPM Mutual Recognition Arrangement (MRA) designated Track A comparison within OAWG implementation CCQM Strategy...
Azaspiracids (AZAs) are marine biotoxins produced by dinoflagellates that can accumulate in shellfish, which if consumed lead to poisoning events. AZA7-10, 7-10, were isolated from shellfish and their structures, previously proposed on the basis of only LC-MS/MS data, confirmed NMR spectroscopy. Purified AZA4-6, 4-6, 7-10 accurately quantitated qNMR used assay cytotoxicity with Jurkat T lymphocyte cells for first time. LC-MS(MS) molar response studies performed using isocratic gradient...
Over the last decade amino acid beta-N-methylamino-L-alanine (BMAA) has come under intense scrutiny. International laboratory and epidemiological research continues to support hypothesis that environmental exposure BMAA (e.g., through dietary practices, water supply) can promote risk of various neurodegenerative diseases. A wide variety cyanobacteria spp. have previously been reported produce BMAA, with production levels dependent upon species, strain conditions. Since spirulina (Arthrospira...
The non-protein amino acid β-methylamino-L-alanine (BMAA) has been linked to neurodegenerative disease and reported throughout the environment. Proposed mechanisms of bioaccumulation, trophic transfer chronic toxicity BMAA rely on hypothesis protein misincorporation. Poorly selective methods for analysis have led controversy. Here, a recently highly method quantitation using hydrophilic interaction liquid chromatography-differential mobility spectrometry-tandem mass spectrometry...
Okadaic acid (OA) and its analogs dinophysistoxins-1 (DTX1) -2 (DTX2) are lipophilic polyethers produced by marine dinoflagellates. These toxins accumulate in shellfish cause diarrhetic poisoning (DSP) humans. Regulatory testing of is essential to safeguard public health for international trade. Certified reference materials (CRMs) play a key role analytical monitoring programs. This paper presents an overview the interdisciplinary work that went into planning, production, certification...
Okadaic acid (OA) and its analogs, dinophysistoxins-1 (DTX1) -2 (DTX2) are lipophilic biotoxins produced by marine algae that can accumulate in shellfish cause the human illness known as diarrhetic poisoning (DSP). Regulatory testing of is required to protect consumers seafood industry. Certified reference materials (CRMs) essential for development, validation, quality control analytical methods, thus play an important role toxin monitoring. This paper summarizes work on research development...
Azaspiracids belong to a family of more than 50 polyether toxins originating from marine dinoflagellates such as Azadinium spinosum. All the azaspiracids reported thus far contain 21,22-dihydroxy group. Boric acid gel can bind selectively compounds containing vic-diols or α-hydroxycarboxylic acids via formation reversible boronate complexes. Here we report use capture and release extracts blue mussels. Analysis fractions by liquid chromatography–tandem mass spectrometry (LC–MS) showed that...
Two high-mass polar compounds were observed in aqueous side-fractions from the purification of okadaic acid (1) and dinophysistoxin-2 (2) Dinophysis blooms Spain Norway. These isolated shown to be 24-O-β-d-glucosides 1 2 (4 5, respectively) by nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, enzymatic hydrolysis. These, together with standards 1, 2, dinophysistoxin-1 (3), a synthetic specimen 7-deoxy-1 (7), combined an understanding their spectrometric fragmentation...