A5080291811- Cancer-related molecular mechanisms research
- Microbial Natural Products and Biosynthesis
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
- Medical Imaging and Analysis
- Bone Tumor Diagnosis and Treatments
- Marine Sponges and Natural Products
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Analytical Chemistry and Chromatography
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Crystallization and Solubility Studies
- Neurogenetic and Muscular Disorders Research
- Sarcoma Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- X-ray Diffraction in Crystallography
- RNA Research and Splicing
- Spinal Fractures and Fixation Techniques
- Analytical Methods in Pharmaceuticals
- Crystallography and molecular interactions
- Neurogenesis and neuroplasticity mechanisms
- Connexins and lens biology
Shanxi Medical University
2019-2022
First Hospital of Shanxi Medical University
2022
China Medical University
2011-2021
First Hospital of China Medical University
2012-2021
Ocean University of China
2020-2021
Capital Medical University
2018-2019
Fudan University
2003
Center for Life Sciences
2003
Rheumatoid arthritis is a common autoimmune disease linked to chronic inflammation. Dysbiosis of the gut microbiota has been proposed contribute risk RA, and large number researchers have investigated gut–joint axis hypothesis using collagen-induced rats. However, previous studies mainly involved short-term experiments; very few used CIA model investigate changes in over time. Moreover, research failed use carry out detailed investigations effects drug treatments upon inflammation joints,...
As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, molecular mechanisms responsible for ES remain poorly understood. In this study, we aimed explore whether Wnt5a, a putative pro-metastatic factor, plays role in metastasis.Expression Wnt5a CXCR4 was determined real-time PCR or Western blot 15 specimens 4 cell lines, A-673, RD-ES, SK-N-MC SK-ES-1. Expression Wnt...
microRNAs (miRNAs) play an important regulatory role in the self-renewal and differentiation of stem cells. In this study, we examined effects miRNA-124 (miR-124) overexpression bone marrow-derived mesenchymal particular, focused on effect cells into neurons. First, used GeneChip technology to analyze expression miRNAs cells, neural miR-124 was substantially reduced compared with other cell types. We constructed a lentiviral vector overexpressing transfected it Intracellular levels neuronal...
Osteoporosis is a disease characterized by loss of bone mass and degeneration the microstructure bone. Resveratrol (3,5,4-tri-hydroxystilbene; RESV) may delay onset variety age-related diseases. In present study, an ovariectomized female rat model was used to detect changes in microRNAs (miRNAs/miRs) following RESV treatment. Subsequently, target genes miRNA were predicted using TargetScan software determined dual-luciferase reporter assay. Finally, role miR-338-3p proliferation...
Main text The CCQM-K148.b comparison, undertaken with a parallel pilot study CCQM-P187.b, was coordinated by the BIPM and UME on behalf of Consultative Committee for Amount Substance: Metrology in Chemistry Biology (CCQM) Working Group Organic Analysis (OAWG). It National Measurement Institutes (NMIs) Designated (DIs) which provide measurement services organic analysis under CIPM Mutual Recognition Arrangement (MRA) designated Track A comparison within OAWG implementation CCQM Strategy...
Main text The CCQM-K179 comparison, undertaken with a parallel pilot study CCQM-P224, was coordinated by the BIPM and UME on behalf of Consultative Committee for Amount Substance: Metrology in Chemistry Biology (CCQM) Working Group Organic Analysis (OAWG). It National Measurement Institutes (NMIs) Designated (DIs) which provide measurement services organic analysis under CIPM Mutual Recognition Arrangement (MRA) designated Track C comparison within OAWG implementation CCQM Strategy Programme...
Three new aspochracin-type cyclic tripeptides, sclerotiotides M–O (1–3), together with three known analogues, sclerotiotide L (4), F (5), and B (6), were obtained from the ethyl acetate extract of fungus Aspergillus insulicola HDN151418, which was isolated an unidentified Antarctica sponge. Spectroscopic chemical approaches used to elucidate their structures. The absolute configuration side chain in compound 4 elucidated for first time. Compounds 1 2 showed broad antimicrobial activity...
Osteosarcoma (OS) is a high-grade malignant bone tumor. Therefore, using both in vitro and vivo assays, the effects of degraded iota-Carrageenan (ι-CGN) on human osteosarcoma cell line, HOS, were examined. Degraded ι-CGN was observed to induce apoptosis G1 phase arrest HOS cells. Moreover, suppressed tumor growth established xenograft models. Accordingly, survival rate these mice significantly higher than that bearing tumors treated with native or PBS. In addition, formation intratumoral...
Abstract Background Hearing impairment is one of most frequent birth defects, which affects nearly 1 in every 1,000 live births. However, the molecular etiology non‐syndromic deafness China not well studied. Here, we have investigated presence mutations three genes commonly mutated patients Shanxi Province, has highest frequency defects China. Methods In total, 1,201 unrelated and 300 healthy individuals were enrolled. The hearing ability was confirmed by audiologic evaluation. Three major...
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a newly characterized oncoprotein involved in variety malignant tumors. However, its expression pattern and biological functions osteosarcoma remain unclear. In the present study, CIP2A was analyzed 51 human specimens using immunohistochemistry. siRNA used MG-63 cell line, effect depletion on proliferation invasion evaluated. We found that overexpressed 76.5 % (39/51) tissues, while normal bone tissues showed negative expression....
Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D-H (1-5), were obtained characterized from the cultures of marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton nocarterphenyl D (1) was defined to possess a rare 2,2'-bithiazole scaffold, naturally occurring for first time, E-H (2-5) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions....
Purpose: Osteosarcoma is a malignant bone tumor. RhoBTB2 protein participated in various cellular activities and influenced pathways responsible for cell cycle apoptosis. To address its potential as therapeutic target osteosarcoma, this study investigated the effect of expression on osteosarcoma tissue cell. Materials Methods: Real-time PCR immunohistochemistry analysis were performed to evaluate level mRNA 121 specimens. The relationship with clinicopathological parameters patients was...
(2021). Accurate simulation of the herniated cervical intervertebral disc using controllable expansion: a finite element study. Computer Methods in Biomechanics and Biomedical Engineering: Vol. 24, No. 8, pp. 897-904.
Bone marrow mesenchymal stem cells (BMSC) are common seed for transplantation. However, there some limitations in their use that have not yet been resolved. Our research modified tumor-related genes temporarily on BMSC which simulated tumorigenesis vitro. The were named tumor-like bone (TT-BMSC).Cultivation of TT-BMSC: cultured and identified, then the transfected MMP-2 gene expressive vector screened 4 weeks by G418. Finally, anti-oncogene PTEN was knockdown ribonucleic acid interference...
Xueshuan Xinmaining Tablet (XXT) is a widely used traditional Chinese medicine for the treatment of stroke, chest pain, coronary heart disease, and angina pectoris caused by blood stasis. Having multiple-component preparation, it still far from meeting requirements modernization standardization because its detailed chemical basis action mechanism have not been clarified. In this work, different batches XXT samples were analyzed HPLC typical sample was UPLC-ESI-Q-TOF/MS to understand...
Lumbar disc herniation (LDH) is a term used for group of conditions, including back pain, femoral nerve pain and sciatica. Currently available treatments surgical options are insufficient patients with LDH. Fructus Ligustri Lucidi (FLL) herb that treating age‑associated diseases. The results the present study suggested FLL may be treatment In study, matrix metalloproteinase‑1, ‑3, ‑8 ‑9 (MMP‑1, ‑9) protein mRNA expression downregulation was observed in LDH according to western blotting...