A5077105471- Analytical Chemistry and Chromatography
- Pesticide Residue Analysis and Safety
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Chemical Thermodynamics and Molecular Structure
- Analytical Methods in Pharmaceuticals
- Radical Photochemical Reactions
- Hormonal and reproductive studies
- Scientific Measurement and Uncertainty Evaluation
- Mycotoxins in Agriculture and Food
- Catalytic C–H Functionalization Methods
- SARS-CoV-2 detection and testing
- Radioactive Decay and Measurement Techniques
- Spectroscopy and Chemometric Analyses
- SARS-CoV-2 and COVID-19 Research
- Chemical and Physical Properties in Aqueous Solutions
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- Folate and B Vitamins Research
- Cyclopropane Reaction Mechanisms
- Isotope Analysis in Ecology
- Analytical Chemistry and Sensors
- Computational Drug Discovery Methods
- Chemistry and Chemical Engineering
- Porphyrin Metabolism and Disorders
Bureau international des poids et mesures
2014-2024
Thermo Fisher Scientific (United Kingdom)
2012
Australian Government
2003
Australian National University
1987-1989
University of Wisconsin–Madison
1988
University of Cambridge
1987
Institute of Medicinal Plant Development
1987
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of suitably constituted aryl, alkyl, or vinyl radicals by acyl cyano group migrationAthelstan L. J. Beckwith, D. M. O'Shea, and Steven W. WestwoodCite this: Am. Chem. Soc. 1988, 110, 8, 2565–2575Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ja00216a033https://doi.org/10.1021/ja00216a033research-articleACS PublicationsRequest reuse...
Abstract The “purity” of an organic compound typically refers, in practice, to assignment the mass fraction content primary component present material. value calibrator material is ultimate source metrological traceability any quantitative measurement that a given matrix. may consist Certified Reference Material (CRM) whose purity has been assigned by CRM producer or laboratory choose value-assign extent necessary for their intended application using appropriately valid methods. This report...
A. L. J. Beckwith, D. M. O'Shea, S. Gerba and W. Westwood, Chem. Soc., Commun., 1987, 666 DOI: 10.1039/C39870000666
A mass balance method is described for determining the fraction of main component a high purity organic material. The resulting assigned value established to be traceable SI and can determined with small associated measurement uncertainty. Pure materials values uncertainties in this way are necessary as primary calibrators reference systems order underpin metrological traceability routine results. has been applied which components were respectively theophylline, digoxin, 17β-estradiol,...
Abstract Anabolic androgenic steroids (AAS) are metabolized extensively in the human body, resulting mainly formation of glucuronide conjugates. Current detection methods for AAS based on gas chromatographic/mass spectrometric (GC/MS) analysis hydrolyzed steroid aglycones. These analyses require laborious sample preparation steps and therefore time consuming. Our interest was to develop a rapid straightforward method intact glucuronides biological samples, using liquid‐phase microextraction...
As a prelude to the development of orally active erythropoietin (EPO) and granulocyte-colony stimulating factor (G-CSF), conjugates have been formed between these molecules vitamin B12. During formation intramolecular cross-linking proteins was avoided by use hydrazidyl derivatives A potentially biodegradable linkage B12 G-CSF reaction buried thiol in with long chain dithiopyridyl derivative In vitro vivo testing showed that their bioactivity substantially maintained they were actively...
Main text The CCQM-K78.b key comparison was coordinated by the Bureau International des Poids et Mesures (BIPM) on behalf of CCQM Organic Analysis Working Group (OAWG) 'Comité Consultatif pour la Quantité de Matière' (CCQM), for National Measurement Institutes (NMIs) and Designated (DIs) providing measurement services in organic analysis under Mesures' (CIPM) Mutual Recognition Arrangement (MRA). This conducted as a 'Track A' within OAWG's 10-year strategic plan. goal to underpin...
Main text The CCQM-K148.b comparison, undertaken with a parallel pilot study CCQM-P187.b, was coordinated by the BIPM and UME on behalf of Consultative Committee for Amount Substance: Metrology in Chemistry Biology (CCQM) Working Group Organic Analysis (OAWG). It National Measurement Institutes (NMIs) Designated (DIs) which provide measurement services organic analysis under CIPM Mutual Recognition Arrangement (MRA) designated Track A comparison within OAWG implementation CCQM Strategy...
Main text The CCQM-K179 comparison, undertaken with a parallel pilot study CCQM-P224, was coordinated by the BIPM and UME on behalf of Consultative Committee for Amount Substance: Metrology in Chemistry Biology (CCQM) Working Group Organic Analysis (OAWG). It National Measurement Institutes (NMIs) Designated (DIs) which provide measurement services organic analysis under CIPM Mutual Recognition Arrangement (MRA) designated Track C comparison within OAWG implementation CCQM Strategy Programme...
Conjugates have been synthesized between vitamin B12 and two lysyl derivatives of the LHRH antagonist, ANTIDE. Lys6-ANTIDE Lys8-ANTIDE were both found to similar activities native analogue in vitro pituitary cell assay. The bioactivity VB12-ANTIDE conjugates was preserved following linkage using a number spacers; however, vivo lost. In order produce which had analogue, it necessary link VB12 ANTIDE analogues thiol cleavable spacers. resultant activity also be much more water soluble than...
Abstract The evaluation of seven internal standard reference materials (ISRMs) to act as a ‘universal’ SI-traceable calibrator suite for organic compound purity determination by quantitative nuclear magnetic resonance (qNMR) spectroscopy is described. set compounds demonstrated constitute such are: potassium hydrogen phthalate (KHP), maleic acid (MA), 3,5- bis -trifluoromethyl benzoic (BTFMBA), dimethyl sulfone (DMSO 2 ), terephthalate (DMTP), 1,4- -trimethlsilyl benzene (BTMSB or BTMSB- d 4...
Standardized results for laboratory tests are particularly important when their interpretation depends on fixed medical practice guidelines or common reference intervals. The community has developed a roadmap an infrastructure to achieve standardized test described in the International Organization Standardization standard 17511:2020 In vitro diagnostic devices - Requirements establishing metrological traceability of values assigned calibrators, trueness control materials and human samples....
Under the auspices of Organic Analysis Working Group (OAWG) Comit? Consultatif pour la Quantit? de Mati?re (CCQM) a key comparison, CCQM K55.b, was coordinated by Bureau International des Poids et Mesures (BIPM) in 2010/2011. Nineteen national measurement institutes and BIPM participated. Participants were required to assign mass fraction aldrin present as main component comparison sample for CCQM-K55.b which consisted technical grade obtained from National Measurement Institute Australia...
Rationale The prohormone angiotensin I (ANG I) [amino acid sequence: DRVYIHPFHL] and other structurally related peptide hormones play an essential role in the regulation of water electrolyte balance human body as well blood pressure. ANG is a biomarker for hypertension diabetes. Therefore, well‐characterized pure reference materials comparable SI‐traceable analytical characterization methods are required to establish measurement systems (RMS) laboratory medicine. Methods Two based on liquid...
Under the auspices of Organic Analysis Working Group (OAWG) Comité Consultatif pour la Quantité de Matière (CCQM) a key comparison, CCQM K55.c, was coordinated by Bureau International des Poids et Mesures (BIPM) in 2012. Twenty National Measurement Institutes or Designated and BIPM participated. Participants were required to assign mass fraction valine present as main component comparison sample for CCQM-K55.c. The samples prepared from analytical grade L-valine purchased commercial supplier...
Under the auspices of Organic Analysis Working Group (OAWG) Comité Consultatif pour la Quantité de Matière (CCQM) a key comparison, CCQM K55.a, was coordinated by Bureau International des Poids et Mesures (BIPM) in 2009/2010. Eleven national measurement institutes and BIPM participated. Participants were required to assign mass fraction estradiol present as main component comparison sample (CCQM-K55.a) which consisted bulk hemihydrate material obtained from commercial supplier that had been...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of monocrotaline by nucleophilic macrolactonizationEdwin Vedejs, S. Ahmad, D. Larsen, and WestwoodCite this: J. Org. Chem. 1987, 52, 17, 3937–3938Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/jo00226a045https://doi.org/10.1021/jo00226a045research-articleACS PublicationsRequest reuse permissionsArticle Views554Altmetric-Citations23LEARN...
Under the auspices of Protein Analysis Working Group (PAWG) Comité Consultatif pour la Quantité de Matière (CCQM) a key comparison, CCQM-K115, was coordinated by Bureau International des Poids et Mesures (BIPM) and Chinese National Institute Metrology (NIM). Eight Institutes or Designated BIPM participated. Participants were required to assign mass fraction human C-peptide (hCP) present as main component in comparison sample for CCQM-K115. The samples prepared from synthetic hCP purchased...