Giuseppe Di Lucca
A5035223901- Renal cell carcinoma treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cancer Immunotherapy and Biomarkers
- Family Support in Illness
- Intensive Care Unit Cognitive Disorders
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Frailty in Older Adults
- Greenhouse Technology and Climate Control
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Dermatological and COVID-19 studies
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Metastasis and carcinoma case studies
- Cancer survivorship and care
- Resilience and Mental Health
- Nutrition and Health in Aging
- Agricultural Practices and Plant Genetics
- Cancer Genomics and Diagnostics
- Potato Plant Research
- Advanced Breast Cancer Therapies
- Brain Metastases and Treatment
Accademia Italiana Medicina Osteopatica
2012-2024
IRCCS Ospedale San Raffaele
1994-2023
University of Milano-Bicocca
2023
Vita-Salute San Raffaele University
1993-2022
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020-2022
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2022
Presidio Ospedaliero
2018
Azienda Ospedaliera San Gerardo
2014
Civil Hospital Karachi
2011
San Raffaele University of Rome
1991-1994
Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), and systemic inflammation is high. In areas pandemic outbreak, the number can exceed maximum capacity intensive care units (ICUs), and, thus, these individuals often receive non-invasive ventilation outside ICU. Effective treatments for this population are needed urgently. Anakinra a recombinant interleukin-1 receptor antagonist that might be beneficial in patient population.We...
Abstract Antioxidants are believed to be important in the prevention of diseases such as cancer and cardiovascular disease. Lycopene is one main antioxidants found fresh tomatoes processed tomato products. The lycopene content also accounts for redness fruit, which qualities industry consumers now look. Other carotenes (such β‐carotene), vitamin C, E various phenolic compounds thought health‐promoting factors with antioxidant properties. Since may depend on genetic factors, choice variety...
PurposeIndividuals with diabetes/stress hyperglycemia carry an increased risk for adverse clinical outcome in case of SARS-CoV-2 infection. The purpose this study was to evaluate whether is, at least part, modulated by increase thromboembolic complications.MethodsWe prospectively followed 180 hospitalized patients confirmed COVID-19 pneumonia admitted the Internal Medicine Units San Raffaele Hospital. Data from 11 out were considered incomplete and excluded analysis. We analysed...
Non-invasive mechanical ventilation (NIV) is effective for symptom relief and respiratory support in patients with insufficiency, severe comorbidities no indication to intubation. Experience NIV as the ceiling of treatment severely compromised novel coronavirus disease (COVID-19) lacking.We evaluated 159 COVID-19-related acute syndrome (ARDS), 38 whom treatment, admitted an ordinary ward treated continuous positive airway pressure (CPAP) physiotherapy. Treatment failure death were correlated...
Purpose Adjuvant chemotherapy improves survival of patients with gastric cancer. Intergroup Trial Chemotherapy in Adenocarcinoma the Stomach (ITACA-S) was a phase III study comparing sequential FOLFIRI followed by docetaxel/cisplatin versus 5-fluorouracil monotherapy. The intensive regimen not superior terms disease-free (DFS) and overall (OS). Methods treatment to be started within 8 weeks from surgery. This analysis evaluates impact time surgery start (TSC) on outcomes. Results Out 1,106...
12112 Background: Psychological research is currently surging in oncological settings, with the construct of psychological distress gaining significant attention. Several studies have demonstrated that can profound adverse effects on adherence, therapy compliance, medical treatments, and overall quality life (NCCN, 2015). However, it remains a challenging endeavor to attain clear understanding implications daily lives oncology patients. To address this gap, our study aimed identify central...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related disease (COVID-19) is an infectious characterized by systemic inflammation, which might enhance baseline thrombotic risk, especially in hospitalized patients. Little is, however, known about predictors of complications patients with COVID-19.We prospectively followed up 180 COVID-19 Demographics, clinical and laboratory features at presentation past medical history were tested as the first complication through multivariate...
Respiratory infections can be complicated by acute brain failure. We assessed delirium prevalence, predictors and outcomes in COVID-19 ED patients.This was a retrospective observational study conducted at the San Raffaele (Italy). Patients age >18 years attending between 26 February 2020 30 May who had positive molecular nasopharyngeal swab for SARS-CoV-2 were included. The Chart-Based Delirium Identification Instrument (CHART-DEL) used to retrospectively assess delirium. Univariable...
Older individuals face an elevated risk of developing geriatric syndromes when confronted with acute stressors like COVID-19. We assessed the connection between in-hospital delirium, malnutrition, and frailty in a cohort COVID-19 survivors. Patients aged ≥65, hospitalized tertiary hospital Milan for SARS-CoV-2 pneumonia, were enrolled screened delirium 4 ‘A’s Test (4AT) performed twice daily (morning evening) during stay. Malnutrition was malnutrition universal screening tool (MUST) at...
4017 Background: Combination chemotherapy (CT) prolonged progression-free survival at 6 months (PFS6) of patients (pts) with MPA from <20% gemcitabine (GEM) to >50%. To prolong CT over has unproven benefit and is hampered by cumulative toxicity. This open-label, randomised, multi-centre phase II trial explored the role MS in pts without progressive disease (PD) after CT, using an O group as calibration arm. The circulating endothelial cells (CEC) biomarker activity was explored....
Interleukin-2 (IL-2) is a cytokine with proven activity against metastatic renal cell carcinoma (RCC) and malignant melanoma (MM). The intravenous administration of high-dose IL-2 limited by important cardiovascular side effects such as hypotension, fluid retention, arrhythmias, myocardial ischemia, which often cause dose reduction and/or treatment withdrawal. occurrence these toxic events not predicted routine pretreatment examinations. aim the present study was to test reliability serial...
Context To prolong chemotherapy over 6 months in metastatic pancreatic adenocarcinoma (MPA) has unproven benefit and is hampered by cumulative toxicity. Objective This phase II trial explored the role of maintenance sunitinib (MS), using an observation (O) group as calibration arm. The predictive circulating endothelial cells (CEC) functional polymorphisms (SNPs) genes involved activity, metabolism transport ( VEGFA , VEGFR-2 CYP3A5 CYP1A1 ABCB1 ABCG2 ) was explored. Methods Patients with...
A 63-year-old woman receiving recombinant interleukin-2 (rlL-2) + lymphokine activated killer cells for metastatic renal cell carcinoma developed autoimmune thyroiditis with clinical hypothyroidism and high titer anti-thyroglobulin anti-microsomal antibodies. The onset of thyroid dysfunction was associated tumor regression resulted in complete response at the end treatment. Cytologic cytofluorimetric studies on tissue showed two distinct populations, mainly consisting small lymphocytes large...