A5023685149- Phytochemicals and Antioxidant Activities
- Food composition and properties
- Fatty Acid Research and Health
- Fungal Biology and Applications
- Protein Hydrolysis and Bioactive Peptides
- Antioxidant Activity and Oxidative Stress
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Natural Antidiabetic Agents Studies
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Hibiscus Plant Research Studies
- Diet and metabolism studies
- Natural product bioactivities and synthesis
- Nutritional Studies and Diet
- Free Radicals and Antioxidants
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
- Pomegranate: compositions and health benefits
- Neuropeptides and Animal Physiology
- RNA Research and Splicing
- Cardiovascular Disease and Adiposity
- Tea Polyphenols and Effects
- Biofuel production and bioconversion
Universidad Autónoma de Madrid
2017-2021
Madrid Institute for Advanced Studies
2017-2021
IMDEA Food
2017-2021
Hospital La Paz Institute for Health Research
2013-2019
Hospital Universitario La Paz
2010-2017
Complejo Hospitalario de Salamanca
2011
Instituto de Ciencia y Tecnología de Alimentos y Nutrición
2006-2010
Consejo Superior de Investigaciones Científicas
2007-2009
Universidad Complutense de Madrid
2008
Unilever (Netherlands)
2005
Hydroxytyrosol and its lipophilic derivatives reduce the metabolic imbalance induced by high-fat diets.
Metabolite production and antioxidant released during colonic fermentation of naturally occurring dietary fiber (DF) from two European diets (Mediterranean Scandinavian) were determined. With this aim, DF associated components isolated both whole diets, as well cereals fruits vegetables comprising the diets. was used substrate for in a dynamic vitro model colon, samples collected, metabolites analyzed. Statistical differences between observed concentrations short-chain fatty acids ammonia...
Summary Several tropical fruits have been described as natural sources of dietary fibre (DF) and phenolic compounds, associated with different health effects. The aim this work was to ascertain the DF, compounds content (including non‐extractable polyphenols, mostly DF) antioxidant capacity in acerola cashew apples from selected clones. ‘BRS 236’ presented a high because combination both extractable polyphenols l ‐ascorbic acid (providing together Folin value 170 kg −1 g d.m.). ‘CCP 76’...
Mushrooms are a source of dietary fiber (DF) with cholesterol-lowering effect. However, their underlying mechanisms poorly understood. The effect DF-enriched fractions from three mushrooms species on cholesterol-related expression was studied in vitro. Pleurotus ostreatus DF fraction (PDF) used mice models to assess its potential palliative or preventive against hypercholesterolemia. PDF induced transcriptional response Caco-2 cells, suggesting possible In the setting, reduced hepatic...
A water extract from Lentinula edodes (LWE) showed HMG-CoA reductase inhibitory activity but contained no statins. NMR indicated the presence of water-soluble α- and β-glucans fucomannogalactans. Fractions containing derivatives these polysaccharides with molecular weight down to approximately 1 kDa still retained their activity. Once digested LWE was applied Caco2 in transport experiments, significant effect noticed on modulation cholesterol-related gene expression. But, when lower...
Herein, two shiitake fractions were obtained: the ergosterol-enriched fraction exerted higher <italic>in vitro</italic> hypocholesterolemic activity and β-glucan-enriched reduced cholesterol levels in mice.
BackgroundGlioblastoma is the most aggressive primary brain tumour and has a very poor prognosis. Inhibition of c-Src activity in glioblastoma stem cells (GSCs, responsible for lethality) by peptide TAT-Cx43266–283 reduces tumorigenicity, boosts survival preclinical models. Because can modulate cell metabolism several reports revealed clinical efficacy various antitumoral drugs due to metabolic rewiring cancer cells, here we explored inhibition advantageous GSC plasticity inhibitor...
Branched-chain amino acids (BCAAs) are key substrates in the formation of fusel alcohols, important flavour components fermented foods. The first step catabolic BCAA degradation is a transaminase step, catalyzed by branched-chain acid (BCAAT). Saccharomyces cerevisiae possesses mitochondrial and cytosolic BCAAT, Bat1p Bat2p, respectively. In order to study impact BCAATs on alcohol production derived from metabolism, S. BCAAT-deletion mutants were constructed. l-leucine was exogenously...
Eritadenine enriched extracts from shiitake might be used in functional foods since they are safe, bioavailable and hypocholesterolemic rats.
Summary Chocolate and soluble cocoa powders are dietary sources of antioxidants. The literature reports antioxidant capacity (AC) derived from aqueous‐organic extracts polyphenols; however, the residue these contains appreciable amounts nonextractable polyphenols (condensed tannins or proanthocyanidins), which may become bioactive antioxidants after colonic fermentation. objective this work was to determine total AC products including both extractable polyphenols. Three methods were used:...
Benefits of n-3 polyunsaturated fatty acids (PUFAs) against cardiovascular diseases have been reported. Vascular tone regulation is largely mediated by endothelial factors whose release modulated sex hormones. Since the incidence pathologies has correlated with decreased levels hormones, aim this study was to analyze whether a diet supplemented specific PUFA docosahexaenoic acid (DHA) could prevent vascular changes induced an impaired gonadal function. For purpose, control and...
Contradictory results have been reported in studies associating dietary fiber (DF) intake and the incidence of colorectal cancer. Most focused mainly on amount total DF, but DF is a heterogeneous complex its components are generally ignored. The aim this work was to compare composition Murcia (Spain) Copenhagen (Denmark). Total 31% higher than Copenhagen, ratio insoluble DF/soluble being similar two diets. contains major amounts nonstarch polysaccharides polyphenolic compounds, derived from...
Breast cancer is the second leading cause of death in women United States. While mammography and breast magnetic resonance imaging (MRI) improve detection early disease, there remains an unmet need for biomarkers risk stratificat
Interest in food matrices supplemented with mushrooms as hypocholesterolemic functional foods is increasing. This study was to (i) investigate the activity of lard functionalized mushroom extracts (LF) including fungal β-glucans, water-soluble polysaccharides, or ergosterol and (ii) examine LF influence on transcriptional mechanisms involved cholesterol metabolism. mRNA levels 17 cholesterol-related genes were evaluated jejunum, cecum, liver high cholesterol-fed mice. The four tested LFs...
Over the past few decades, cardiovascular benefits of a high dietary intake long-chain polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA), have been extensively studied. However, many molecular mechanisms and effects exerted by PUFAs yet to be well explained. The lack sex hormones alters vascular tone, we described that DHA-supplemented diet orchidectomized rats improve function aorta. Based on these data since mesenteric artery importantly controls systemic resistance,...