A5086493558- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Neuroendocrine regulation and behavior
- Pharmaceutical Practices and Patient Outcomes
- Schizophrenia research and treatment
- Liver Disease Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Amino Acid Enzymes and Metabolism
- Electrolyte and hormonal disorders
- Diet, Metabolism, and Disease
- Glioma Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Pharmacovigilance and Adverse Drug Reactions
- Anatomy and Medical Technology
- Child and Adolescent Health
- Health, psychology, and well-being
- Treatment of Major Depression
- Medication Adherence and Compliance
- Biochemical Acid Research Studies
- Innovations in Medical Education
- Child Abuse and Related Trauma
- Neurological and metabolic disorders
- Brain Metastases and Treatment
- Adipose Tissue and Metabolism
Medizinische Hochschule Hannover
2018-2025
Hamilton General Hospital
2020
McMaster University
2020
University Hospital Cologne
2020
Beth Israel Deaconess Medical Center
2016
The majority of patients with alcohol use disorder (AUD) regularly take medication. Alcohol interacts negatively many commonly prescribed drugs. However, little is known about the characteristics and frequency potential alcohol-medication drug-drug interactions in AUD. This study aimed to determine prevalence drug AUD during withdrawal therapy on an addiction-specific ward. Retrospective cohort study. Medication charts were analyzed screened for interactions. For screening interactions,...
Olfactory dysfunction (OD) is a disorder associated with traumatic brain injury (TBI), which prevalent in up to 20% of patients suffering from TBI. Nevertheless, most studies focusing on the relationship between OD and TBIs do not differentiate different types TBI (mild, medium, severe). In this paper, we conducted comprehensive systematic review existing literature for association mild (mTBI) order examine their relationship, its neurosurgical management radiographic characteristics.The...
Background: Older patients with alcohol use disorder are at particular risk of developing adverse drug reactions due to multimorbidity, polypharmacy, and altered organ function. Objectives: In this study, we investigated the frequency characteristics potentially serious alcohol–medication interactions, inappropriate medications (PIMs) for older adults, potential drug–drug interactions (pDDIs) in a population over 10-year period. Design: Retrospective monocentric cohort study. Methods:...
Several studies reported dysregulated protein levels of brain-derived neurotrophic factor (BDNF) in smokers and during cessation. However, the epigenetic regulation BDNF gene has not yet been investigated. We measured plasma exon IV compared to healthy controls over a cessation period 14 days.We promoter methylation 49 51 non-smokers at baseline, day 7, smoking Mean 11 Cytosine Guanosine dinucleotides were determined via bisulfite sequencing.BDNF significantly lower when with across all time...
Fluorescence-guided surgery with five-aminolevulinic acid (5-ALA) is the state-of-the-art treatment of high-grade gliomas. However, intraoperative visualization 5-ALA under blue light remains challenging, especially when blood covers surgical field and thereby fluorescence. To overcome this problem combine brightness visible information delivered fluorescence, we implemented multispectral fluorescence (MFL) in a microscope, technique that able to project both real-time. We prospectively...
The gross anatomy dissection course is considered to be one of the most important subjects in medical school. Advancing technology facilitates production e‐learning material that can improve learning topographic during course. purpose this study was examine a locally produced audiovisual manual's effects on performance dissection, formal knowledge gained, motivation, emotions, behavior, and efficiency students. results, combined with total effort put into manual, should support decisions...
<b><i>Introduction:</i></b> Vasopressin (AVP) and oxytocin (OT) exert sex-specific effects on social pair bonding stress reactions while also influencing craving in substance use disorders. In this regard, intranasal AVP antagonists present potential treatments for tobacco disorder (TUD). Since transcription of both hormones is regulated by gene methylation, we hypothesized changes methylation levels the <i>AVP</i>, <i>OT</i>,...
Background: The prevalence of child maltreatment in adults with congenital heart disease (ACHD) has not been assessed so far. Child is a major risk factor for unfavorable behavioral, mental, and physical health outcomes associated decreased quality life. Given the increased survival time ACHD, it essential to assess factors that may worsen life interact classical cardiovascular mental well-being. Methods: In cross-sectional study, 196 ACHD (mean age 35.21 ± 11.24 y, 44,4% female, 55.6% male)...
Abstract Adverse drug reactions (ADRs) constitute a frequent cause of hospitalization in older people. The risk ADRs is increased by the prescription potentially inappropriate medications for people (PIMs). PRISCUS list and FORTA classification represent established tools to detect PIMs. aim present study was examine prevalence characteristics PIM prescriptions on gerontopsychiatric ward university hospital Germany. To this aim, medication charts 92 patients (mean age 75.9 ± 7.7 years; 66.3%...
Liver transplantation is the only curative treatment available for patients with end-stage alcoholic liver disease. As different studies showed a significant association between leptin plasma levels, gene methylation patterns and extent of craving in alcohol-dependent patients, we investigated effect on expression promoter methylation.The present study shows that cirrhosis significantly higher before decreases after transplantation. Alcohol-dependent waiting list had values than who...
Abstract Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder caused by loss of usually paternally expressed, maternally imprinted genes located on chromosome 15q11-q13. Individuals with PWS display specific behavioral phenotype and have higher susceptibility than the general population for certain psychiatric conditions, especially psychosis. An impairment oxytocin system has been described in syndrome, but not yet investigated detail epigenetic level. Recent studies pointed...
Abstract Aims Alcohol use alters the reward signaling processes contributing to development of addiction. We studied effects alcohol disorder (AUD) on brain regions and blood deceased women men examine sex-dependent differences in epigenetic changes associated with AUD. investigated gene promoter methylation GABBR1 coding for GABAB receptor subunit 1 brain. Methods chose six addiction pathway (nucleus arcuatus, nucleus accumbens, mamillary bodies, amygdala, hippocampus anterior temporal...
Trotz eines relativ weit verbreiteten und zunehmenden Konsums von Gamma-Hydroxybuttersäure in der Partyszene gibt es nur wenige Berichte über die Behandlung GHB-Abhängigkeit – meist mittels hoch dosierter Gabe Benzodiazepinen nach einem individuellen Schema. Klare Behandlungsempfehlungen im Sinne einer Leitlinie liegen bisher nicht vor.
Trotz eines relativ weit verbreiteten und zunehmenden Konsums von Gamma-Hydroxybuttersäure in der Partyszene gibt es nur wenige Berichte über die Behandlung GHB-Abhängigkeit – meist mittels hoch dosierter Gabe Benzodiazepinen nach einem individuellen Schema. Klare Behandlungsempfehlungen im Sinne einer Leitlinie liegen bisher nicht vor.
Abstract Background Differentiating depression and dementia in elderly patients represents a major clinical challenge for psychiatrists. Pharmacological non-pharmacological treatment options both conditions are often used cautiously due to fear of adverse effects. If clinically indicated therapy is not initiated effects, the quality life affected may significantly be reduced. Case presentation Here, we describe case 65-year-old woman who presented department psychiatry university hospital...
The dopamine receptor D2 (DRD2) is substantially involved in several forms of addiction. In addition to genetic polymorphisms, epigenetic mechanisms have emerged as an important means regulation. Previously, DRD2 hypo- and hyper-methylation been observed alcohol use disorder (AUD). Blood samples are commonly used a surrogate marker alterations research, but few specific comparisons between blood brain tissue AUD exist.We post-mortem 17 deceased patients with 31 controls investigate the...
Abstract Background Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder caused by loss of usually paternally expressed, maternally imprinted genes located on chromosome 15q11-q13. Individuals with PWS display specific behavioral phenotype and have higher susceptibility than the general population for certain psychiatric conditions, especially psychosis. An impairment oxytocin system has been described in syndrome, but not yet investigated epigenetic level. Recent studies...