A5002851096- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Trace Elements in Health
- Air Quality and Health Impacts
- Heavy metals in environment
- Folate and B Vitamins Research
- Fluoride Effects and Removal
- Noise Effects and Management
- Selenium in Biological Systems
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Mercury impact and mitigation studies
- Retinoids in leukemia and cellular processes
- Environmental Justice and Health Disparities
- Bone health and osteoporosis research
- Smoking Behavior and Cessation
- Radiation Dose and Imaging
- Occupational and environmental lung diseases
- Metabolism and Genetic Disorders
- Cardiovascular Health and Disease Prevention
- Dye analysis and toxicity
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Indoor Air Quality and Microbial Exposure
- Heart Rate Variability and Autonomic Control
INCLIVA Health Research Institute
2017-2025
Universitat de València
2018-2025
Instituto de Salud Carlos III
2024-2025
Columbia University
2016-2024
Johns Hopkins University
2016-2023
Universidad Autónoma de Madrid
2019-2022
Hospital La Paz Institute for Health Research
2022
Hospital Universitario La Paz
2022
Biomedical Research Institute
2020-2021
Medical Research Network
2016
Background: Electronic cigarettes (e-cigarettes) generate an aerosol by heating a solution (e-liquid) with metallic coil. Whether metals are transferred from the coil to is unknown. Objective: Our goal was investigate transfer of e-liquid in e-cigarette tank and generated aerosol. Methods: We sampled 56 devices daily users obtained samples refilling dispenser, aerosol, remaining tank. Aerosol liquid collected via deposition droplets series conical pipette tips. Metals were reported as mass...
High arsenic exposure has been related to diabetes, but at low-moderate levels the evidence is mixed. Arsenic metabolism, which partly genetically controlled and may rely on certain B vitamins, plays a role in toxicity.We evaluated prospective association of metabolism with type 2 diabetes insulin resistance.We included 1,838 American Indian men women free (median age, 36 y). was assessed as sum inorganic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA) urine concentrations (ΣAs). by...
Abstract Background The association of low-level exposure to metals and metal mixtures with cardiovascular incidence in the general population has rarely been studied. We flexibly evaluated urinary concentrations diseases a representative sample from Spain. Methods Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) zinc (Zn) were measured 1171 adults without clinical diseases, who participated Hortega Study. Cox proportional...
Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in general population. We evaluated cross-sectional association urinary with biomarkers, including oxidized reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), a representative sample population from Spain (Hortega Study). Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) zinc...
Inorganic arsenic exposure is ubiquitous, and both interindividual differences in its metabolism have been associated with cardiometabolic risk. However, the associations of metabolic syndrome (MetS) individual components are relatively unknown. We used Poisson regression robust variance to evaluate baseline (urinary levels) (relative percentage species over their sum) incident MetS (elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol,...
OBJECTIVE Little is known about arsenic and diabetes in youth. We examined the association of with type 1 2 SEARCH for Diabetes Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence metabolism, we also evaluated potential interaction folate vitamin B12 on odds diabetes. RESEARCH DESIGN AND METHODS Six hundred eighty-eight participants <22 years age (429 diabetes, 85 174 control participants) were evaluated. Arsenic species (inorganic [iAs], monomethylated...
Abstract Background The contribution of metabolomic factors to the association healthy lifestyle with type 2 diabetes risk is unknown. We assessed a composite measure plasma metabolite profiles and incident diabetes, whether relevant metabolites can explain prospective between diabetes. Methods A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption BMI) was estimated in 1016 Hortega Study participants, who had targeted...
Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic (DMA), roxarsone or nitarsone concentrations meat. However, the association between intake exposure to these species, as reflected elevated urinary concentrations, is unknown.Our aim was evaluate 24-hr dietary recall of consumption U.S. population. We hypothesized first, that would be associated with higher urine second, turkey increased...
Arsenic exposure has been related to numerous adverse cardiovascular outcomes. The aim of this study was investigate the cross-sectional and prospective association between arsenic with echocardiographic measures left ventricular (LV) geometry functioning. A total 1337 young adult participants free diabetes mellitus disease were recruited from SHFS (Strong Heart Family Study). sum inorganic methylated concentrations in urine (ΣAs) at baseline used as a biomarker exposure. LV functioning...
Selenium and single-nucleotide-polymorphisms in selenoprotein genes have been associated to diabetes. However, the interaction of selenium with genetic variation diabetes oxidative stress-related has not evaluated as a potential determinant risk.We cross-sectional prospective associations plasma concentrations type 2 diabetes, candidate polymorphisms, representative sample 1452 men women aged 18-85 years from Spain.The geometric mean levels study was 84.2µg/L. 120 participants had at...
Abstract Background Arsenic exposure through drinking water is an established lung carcinogen. Evidence on non-malignant outcomes less conclusive and suggests arsenic associated with lower function. Studies examining low-moderate (< 50 μg/L), the level relevant for most populations, are limited. We evaluated association of respiratory health in American Indians from Northern Plains, Southern Plains Southwest United States, communities environmental to inorganic water. Methods The Strong...
Studies evaluating the association of metals with subclinical atherosclerosis are mostly limited to carotid arteries. We assessed individual and joint associations nonessential exposure in 3 vascular territories. Approach Results: One thousand eight hundred seventy-three Aragon Workers Health Study participants had urinary determinations inorganic arsenic species, barium, cadmium, chromium, antimony, titanium, uranium, vanadium, tungsten. Plaque presence femoral arteries was determined by...
OBJECTIVE Hyperglycemia can increase urinary zinc excretion. We evaluated the association of higher level with new diagnosis incident type 2 diabetes mellitus (T2DM) in adult populations a high burden T2DM from AZ, OK, and ND SD. also assessed cross-sectional levels prevalent prediabetes. RESEARCH DESIGN AND METHODS included 1,339 adults free at baseline (1989–1991) followed through 1998–1999 Strong Heart Study (SHS) 1,905 family members SHS participants as part Family (SHFS) 2006–2009....
To assess whether the role of selenium on pre-diabetes is differential by age, given comorbidities and decreased β-cell function in older adults. We evaluated cross-sectional association blood with homeostatic model assessment for insulin resistance (HOMA-IR) (HOMA-β) middle-aged (Aragon Workers Health Study [AWHS], N = 1186), (Seniors ENRICA [Study Nutrition Cardiovascular Risk Spain]-2 [SEN-2], 915) diabetes-free A subsample participants from AWHS (N 571) SEN-2 603) had glucose repeated...
Inorganic arsenic exposure and inter-individual differences in its metabolism have been associated with cardiometabolic risk. A more efficient profile (lower MMA%, higher DMA%) has reduced risk for arsenic-related health outcomes; however, this also increased diabetes-related outcomes. The mechanism behind these contrasting associations is equivocal; we hypothesized one carbon (OCM) may play a role. We evaluated the association between OCM-related variables (nutrient intake genetic variants)...