A5101504901- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Carcinogens and Genotoxicity Assessment
- Lower Extremity Biomechanics and Pathologies
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Genomics, phytochemicals, and oxidative stress
- Sports Performance and Training
- Orthopedic Infections and Treatments
- Polyamine Metabolism and Applications
- DNA Repair Mechanisms
- Orthopaedic implants and arthroplasty
- Sports injuries and prevention
- AI in cancer detection
- Total Knee Arthroplasty Outcomes
- Nail Diseases and Treatments
- Cardiovascular Effects of Exercise
- Dupuytren's Contracture and Treatments
- Bone Tumor Diagnosis and Treatments
- Diet and metabolism studies
- Polyomavirus and related diseases
- Ureteral procedures and complications
- Pelvic and Acetabular Injuries
- Radiomics and Machine Learning in Medical Imaging
- Soft tissue tumor case studies
University of Shizuoka
2021-2024
Sapporo Medical University
2012-2022
Study Design. Using fresh cadavers, the biomechanical testing were used to examine pullout strength of each pedicle screw. Objective. The aim this study was evaluate (1) a redirected screw following lateral wall breach; (2) end-plate and (3) without redirection after breach redirection. Summary Background Data. Screw malposition, such as or breach, is one main pitfalls inserting screws. Methods. From 17 spines, 54 vertebrae harvested. In vertebra on pedicle, inserted correctly down axis...
Pathogenesis of ankle disorders with a large bone defect is varied and treatment for those problems challenging orthopaedic surgeons. The aims this study were to present an operative technique arthrodesis the reconstruction hindfoot using soft tissue-preserved fibular strut graft report outcomes consecutively treated patients.Twelve feet from 11 patients, including aseptic necrosis talus total implant loosening, treated. Bone defects filled iliac and/or resected fibula tibiotalocalcaneal was...
There is insufficient information regarding patient-based outcomes after knee arthrodesis following infected total arthroplasty (TKA). The purpose of this study was to analyze in patients who underwent TKA using clinical and radiographic measurements including a outcome measuring system.We evaluated 8 (mean age 72.9 years) were followed for more than 3 years arthrodesis. Clinical evaluation performed, examination the patient's function use supportive equipment walking. Japanese...
There is insufficient information regarding patient-based outcomes after knee arthrodesis following infected total arthroplasty (TKA). The purpose of this study was to analyze in patients who underwent TKA using clinical and radiographic measurements including a outcome measuring system. We evaluated 8 (mean age 72.9 years) were followed for more than 3 years arthrodesis. Clinical evaluation performed, examination the patient’s function use supportive equipment walking. Japanese...
553 Background: Tumor-infiltrating lymphocytes (TILs) are pivotal in predicting responses to preoperative chemotherapy triple-negative breast cancer. Yet, their clinical adoption as a diagnostic marker is limited by the challenge of achieving high accuracy with objective measures. This study introduces novel AI-based method quantitatively assess stromal TILs within tumor bed using hematoxylin and eosin (H&E)-stained slides, examining correlation disease-free survival (DFS) overall (OS)....
Abstract Occupational exposure to 4,4′-methylenebis(2-chloroaniline) (MOCA) has been linked an increased risk of bladder cancer among employees in Japanese plants, indicating its significance as a factor for urinary cancer. To investigate the role MOCA metabolism carcinogenesis, we administered non-humanized (F1-TKm30 mice) and humanized-liver mice 4 28 wk. We compared MOCA-induced changes metabolic enzyme expression, metabolite formation, effects on epithelium 2 models. At week 4, induced...
This study aimed to evaluate the effects of ankle flexion angle during anterior talofibular ligament (ATFL) reconstruction on kinematics, laxity, and in situ force a graft.Twelve cadaveric ankles were evaluated using 6-degrees freedom robotic system apply passive plantar dorsiflexion motions multidirectional loads. A repeated measures experiment was designed intact ATFL, transected reconstructed ATFL. During ATFL (ATFLR), graft fixed at neutral position (ATFLR 0 degrees), 15 degrees PF15 30...
Although a variety of surgical procedures for anterior talofibular ligament (ATFL) reconstruction have been reported, the effect initial graft tension during ATFL remains unclear.This study investigated effects on reconstruction. We hypothesized that high degree would cause abnormal kinematics and laxity.Controlled laboratory study.Twelve cadaveric ankles were tested with robotic system 6 degrees freedom to apply passive plantarflexion dorsiflexion motions multidirectional load. A repeated...
Background: Although a variety of surgical procedures for lateral ankle ligament reconstruction have frequently been reported, little is known about the effects initial graft tension. Purpose/Hypothesis: The purpose was to investigate tension in calcaneofibular (CFL) reconstruction. It hypothesized that high degree would cause abnormal kinematics, laxity, and excessive Study Design: Controlled laboratory study. Methods: Twelve cadaveric ankles were tested with 6 degrees freedom robotic...
Monocyclic aromatic amines, o-toluidine (o-Tol) and its structural analog o-anisidine (o-Ans), are IARC Group 1 2A urinary bladder carcinogens, respectively, involved in metabolic activation DNA damage. Our recent study revealed that 2-methyl-N4-(2-methylphenyl) benzene-1,4-diamine (MMBD), a p-semidine-type homodimer of o-Tol, was detected identified an vitro reaction o-Tol with S9 mix vivo samples o-Tol-exposed rats. Potent mutagenic, genotoxic, cytotoxic activities were reported MMBD,...
Spirulina widely known to consumers as a health food is mainly dried product. Since data for raw spirulina protein source are insufficient, the nutritional values of dry and diets in Wistar rats were determined. Digestibility coefficients significantly lower (84.1 ± 0.5%) (85.7 0.4%) than that casein diet (96.6 0.2%), although biological (86.3 1.3%) (77.9 2.6%) higher (71.9 2.5%). The digestibility-corrected amino acid score (86.6 was (85.1 0.5%). Additionally, profiling portal/venous blood...
Several aromatic amine compounds are urinary bladder carcinogens. Activated metabolites and DNA adducts of polycyclic amines, such as 4-aminobiphenyl, have been identified, whereas those monocyclic o-toluidine (o-Tol), o-anisidine (o-Ans), aniline (Ani), not completely determined. We recently reported that o-Tol o-Ans metabolically converted in vitro vivo to cytotoxic mutagenic p-semidine-type dimers, namely 2-methyl-N4-(2-methylphenyl) benzene-1,4-diamine (MMBD)...
e13608 Background: The importance of accurately understanding the status tumor-infiltrating lymphocytes (TILs) in preoperative chemotherapy context, for triple-negative breast cancer is underscored, highlighting dual role TILs gauging treatment efficacy and prognostication. However, difficulty quantitatively objectively assessing clinical practice acknowledged, noting barrier to its adoption as a standard diagnostic end-point. This study proposes novel AI-based method overcome these...
A 49 year-old male visited a nearby clinic five years back with complaint of pain in the right knee during exercise. Plain radiographs revealed absence any anomalies. He began to feel lumpy mass his two back. The worsened, on imaging, an anomaly was identified infrapatellar fat pad knee, and he subsequently referred our department where hospitalized. On examination, extending either side patellar tendon along rigid tenderness that area. knee's range motion 0degrees-130degrees, flexion...
Although both o-toluidine and o-anisidine are known as aromatic amines with bladder carcinogenicity, the specific metabolites involved in carcinogenesis still unclear. Here, we examined toxicological effects of head-to-tail dimers o-anisidine, 2-methyl-N4-(2-methylphenyl) benzene-1,4-diamine (MMBD) 2-methoxy-N4-(2-methoxyphenyl) (MxMxBD), respectively, rats. Six-week-old male F344 rats were orally administered MMBD, MxMxBD, o-toluidine, at a dose 100 mg/kg/day for 28 days. Rats 400 mg/kg 600...
Background FIFA 11+ program has been shown to reduce injury risk in female football players but not evaluated an Asian male adolescent players. Objective To investigate the effects of 11 + on a Japanese Design Cohort study. Setting 6 U-18 (age: 16–18) and U-15 13–15) teams followed for three seasons (2010, 2011 2012). The 2010 season, completed usual warm-up as control group, whereas performed throughout entire season intervention group. Participants A total 986 athletes 12–18 years)....
Ankle sprains are common injuries in daily and athletic activities. An epidemiological report indicated that the incidence rate of ankle treated emergency departments USA is more than 2 per 1000 persons a year, estimated to be double as for activity [1]. Better understanding biomechanics is, therefore, important improvement clinical outcome. Many investigators have performed vitro vivo experiments determine mechanical roles structures such range motion, contribution ligaments joint...