A5059672503- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Genetic and phenotypic traits in livestock
- Scheduling and Optimization Algorithms
- Evaluation Methods in Various Fields
- Cancer-related molecular mechanisms research
- Catalytic Cross-Coupling Reactions
- Evaluation and Optimization Models
- Oxidative Organic Chemistry Reactions
- Carbon Nanotubes in Composites
- Regulation of Appetite and Obesity
- Extraction and Separation Processes
- CO2 Sequestration and Geologic Interactions
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Genetic Mapping and Diversity in Plants and Animals
- Identification and Quantification in Food
- Risk and Safety Analysis
- RNA modifications and cancer
- Ruminant Nutrition and Digestive Physiology
- Liver physiology and pathology
- Coal Properties and Utilization
- Cancer, Stress, Anesthesia, and Immune Response
- Meat and Animal Product Quality
Beike Biotechnology (China)
2024
ZheJiang Academy of Agricultural Sciences
2005-2024
Brewer Science (United States)
2014-2024
Harbin University of Science and Technology
2007-2023
Anhui Jianzhu University
2023
East China University of Technology
2023
Tianjin University of Science and Technology
2023
Harbin Medical University
2008-2022
Second Affiliated Hospital of Harbin Medical University
2008-2022
China Electronics Technology Group Corporation
2022
The current prostate cancer (PCa) diagnosis, based on the blood prostate-specific antigen (PSA) level measurement, is not a precise science. widely used PSA biomarker for PCa has poor sensitivity and specificity often leads to false-negative false-positive test results. Recently, sarcosine, proline, kynurenine, uracil, glycerol 3-phosphate were found in higher concentrations metastatic urine samples. By measuring all five of these metabolites, doctors may be better able diagnose with high...
A metal-free intermolecular oxidative C–N formation reaction of aryl ethers with saccharins was realized for the first time.
The major health hazards from smoke and dust are due to microscopic fine particles present in as well dust. These particles, which nature, can penetrate into human lungs give rise a range of problems such irritation eyes, runny nose, throat infection, chronic cardiac lung diseases. There is need device mechanisms that monitor thermal power plants for timely control pollute air affects adversely the people living nearby plants. In order solve low accuracy monitoring results long time...
Modified nucleosides are formed at the post-transcriptional stage by chemical modification of normal within ribonucleic acid (RNA). These modified cannot be reutilized or further degraded, but they excreted in urine as intact molecules. The elevated levels samples have served potential cancer biomarkers many studies. Although different analytical techniques been reported for determining levels, practically difficult to use a routine tool early screening. In this paper, novel method was...
A novel iodine-mediated intermolecular iodosulfonylation reaction of alkenes for dual C–S and C–I bond formation was achieved.
Abstract A novel oxidative CS bond cleavage reaction of DMSO for dual CC and CN formation is described. series acetyl heteroarenes could be selectively converted into the corresponding β‐amino ketones, which are frequently found in biologically active compounds pharmaceuticals. acted this not only as solvent but also a one‐carbon bridge.
Chemotherapy is one of the primary treatments used against cancer. Cisplatin a conventional chemotherapy drug to treat osteosarcoma; however, due development cisplatin resistance, advantageous therapeutic outcomes and prognosis osteosarcoma remain low. Thus, investigation specific targeted therapies circumvent anti-chemoresistance depends on understanding molecular mechanisms underlying resistance. Tumor cells display an increased utilization glycolysis rather than oxidative phosphorylation....
Abstract Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long‐distance organ metastasis. Thus, investigating specifically targeted therapeutic agents against metastatic osteosarcoma depends on understanding molecular mechanisms. The long noncoding RNAs (lncRNA) XIST (X‐inactive specific transcript) has been reported to have oncogenic roles in various malignant tumors including OS. However, its mechanisms OS migration invasion are still under...
A novel oxidative C–S bond cleavage reaction of DMSO for <italic>N</italic>-methylation and subsequent C–C formation is described.
Body weight (BW) is a critical economic trait for meat production in sheep. The current study aimed to perform GWAS detect significant single-nucleotide polymorphisms (SNP) that are associated with BW Hu In summary, the comparison and analysis of G1 G2 generation nucleus sheep breeding herd revealed 11 SNPs, identified by GWAS, be at Bonferroni-corrected genome-wide significance threshold 5%. subsequent verification SNP loci G3 also detected 40 SNPs regions. A total 8 significantly birth...
Body size is an important indicator of growth and health in sheep. In the present study, we performed Genome-Wide Association Studies (GWAS) to detect significant single-nucleotide polymorphisms (SNPs) associated with Hu sheep’s body size. After genotyping parental (G1) offspring (G2) generation nucleus herd for meat production sheep conducting GWAS on height, chest circumference, length, tail width two groups, 5 SNPs height 4 correlated circumference were identified at chromosomal...
Abstract An efficient method for the synthesis of 2‐amino and β‐amino five‐membered heterocyclic derivatives that are closely related to a variety biologically active natural products is described. Regioselectivity was achieved through metal catalytic or organocatalytic approach. Preliminary studies on reaction mechanism suggest radical imidation pathway; however, further needed verify mechanism.
Background: Urinary metabolomic profiles have recently drawn a lot of attention owing to debate regarding their possible role as potential clinical markers for prostate cancer. In this study, levels proline, kynurenine, uracil and glycerol-3-phosphate in 126 patients with genitourinary malignancies were analyzed using validated method compared no evidence malignancy. Results: The statistical results showed that these biomarkers cannot differentiate cancer from malignancy or other related...
A body of studies suggests the role osteopontin (OPN) in onset and development osteoarthritis (OA), however, association between OPN polymorphisms OA susceptibility as well its clinical features has not been reported.A total 750 patients with primary knee 794 healthy volunteer were enrolled controls. Both control groups interviewed to obtain demographic data. Three gene, namely, -156GG/G, -443C/T -66T/G determined. The levels full length thrombin-cleaved synovial fluid (SF) from subjects...
The melanocortin-4 receptor (MC4R) has important roles in regulating food intake, energy balance, and body weight mammals.In pigs cattle, MC4R mutations have been identified as genetic markers for growth traits.Compared with abundant research conducted on other livestock species, little is known about of the ovine gene.We investigated effect polymorphisms birth 45-day weaning 144 Hu sheep.Four single nucleotide (SNPs; g.1016 G/A, g.1240 T/C, g.1264 g.1325 A/G) were 3ꞌ-untranslated region...
A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C–H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility the method demonstrated by gram-scale reaction and derivatization product. Experimental results have confirmed Pd Bi played critical roles in transformation indicated might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.
The origin of domestic donkeys in China has been controversial.To clarify the Chinese donkeys, we investigated partial mitochondrial D-loop sequences 126 samples from 12 native breeds.The results revealed two origins, lineage Somali and Nubian African wild ass detected donkeys.Lineage was predominant donkey pattern genetic variation mtDNA indicated that lineages had undergone population expansion events.In a combined analysis between previously published other countries/regions were Africa...