A5100383354- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Sulfur-Based Synthesis Techniques
- Ophthalmology and Visual Impairment Studies
- Cyclopropane Reaction Mechanisms
- Synthesis and biological activity
- Advanced Synthetic Organic Chemistry
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Traditional and Medicinal Uses of Annonaceae
- Asymmetric Hydrogenation and Catalysis
- Intraocular Surgery and Lenses
- Marine Sponges and Natural Products
- Organoboron and organosilicon chemistry
- Plant-based Medicinal Research
- Retinal and Optic Conditions
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Lipid Membrane Structure and Behavior
- Retinal Diseases and Treatments
Tongji University
2017-2025
Shanghai Tenth People's Hospital
2017-2025
Nanchang University
2025
Southern University of Science and Technology
2020-2024
Lanzhou University
2013-2024
Xi’an Jiaotong-Liverpool University
2024
First Affiliated Hospital of Guangzhou Medical University
2017-2024
Guangzhou Medical University
2017-2024
Lanzhou University Second Hospital
2019-2024
Great Bay University
2022-2024
A visible-light-promoted, mild, and direct difunctionalization of alkynoates has been accomplished. This procedure provides a new strategy toward synthesis the coumarin core structure by photoredox-mediated oxidation to generate α-oxo radical, which supervenes domino radical addition/cyclization reaction in moderate good yields with high regioselectivity at ambient temperature.
The intermolecular asymmetric radical oxidative C(sp3 )-C(sp) cross-coupling of )-H bonds with readily available terminal alkynes is a promising method to forge chiral because the high atom and step economy, but remains underexplored. Here, we report copper-catalyzed (hetero)benzylic (cyclic)allylic C-H that occurs excellent enantioselectivity. Critical success rational design oxazoline-derived N,N,P(O)-ligands not only tolerate strong conditions which are requisite for hydrogen abstraction...
Open AccessCCS ChemistryMINI REVIEWS24 Feb 2024Research Progress in Enantioselective Radical Desymmetrization Reactions Chang-Jiang Yang, Lin Liu, Qiang-Shuai Gu and Xin-Yuan Liu Yang *Corresponding authors: E-mail Address: [email protected] Department of Chemistry Dongguan Key Laboratory for Data Science Intelligent Medicine, Great Bay University, 523000 Shenzhen Grubbs Institute, Chemistry, Guangming Advanced Research Southern University Technology, 518055 , Academy Interdisciplinary...
Abstract Integrin β4 (ITGB4) is a transmembrane receptor involved in tumorigenesis and the invasiveness of many cancers. However, its role hepatocellular carcinoma (HCC), one most prevalent human cancers worldwide, remains unclear. Here, we examined involvement ITGB4 HCC explored underlying mechanisms. Real-time PCR immunohistochemical analyses tissues from 82 patients with four cell lines showed higher levels tumor than adjacent non-tumor normal hepatic cells. Silencing repressed...
The development of enantioconvergent cross-coupling racemic alkyl halides directly with heteroarene C(sp2 )-H bonds has been impeded by the use a base at elevated temperature that leads to racemization. We herein report copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system enables oxidative addition bromides under mild conditions. Thus, coupling azole achieved in high enantioselectivity, affording number potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles,...
Catalytic enantioselective hydroxylation of prochiral dihydrosilanes with water is expected to be a highly efficient way access Si-chiral silanols, yet has remained unknown up date. Herein, we describe strategy for realizing this reaction: using an alkyl bromide as single-electron transfer (SET) oxidant invoking CuII species and chiral multidentate anionic N,N,P-ligands effective enantiocontrol. The reaction readily provides broad range silanols high enantioselectivity excellent functional...
Abstract Background Acetaminophen (APAP) overdose is a major cause of the morbidity acute liver failure. The current clinically approved treatment for APAP poisoning, N -acetylcysteine (NAC), has limited therapeutic window, and prolonged with NAC delays regeneration. Mesenchymal stem cells (MSCs) also have effects on APAP-induced mouse failure, but whether are comparable to those not been determined, mechanism still needs further exploration. Methods Fasted C57BL/6 mice that received 500...
Primary amines serve as key synthetic precursors to most other
Four from one: The four title alkaloids (structures shown in blue box) have been synthesized by using a common versatile intermediate with 6/5/5 tricyclic skeleton. This could be easily assembled an intramolecular carbene addition/cyclization and Dieckmann condensation/Tsuji–Trost allylation as key steps. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials are peer reviewed may re-organized for online delivery, but not...
Abstract Total syntheses of the biologically important and structurally unique tetracyclic diterpenes conidiogenone, conidiogenol, conidiogenone B cyclopiane class are reported. The absolute configuration naturally occurring was also corrected. key step our strategy involved highly efficient construction both ring C quaternary carbon center shared by rings A through a one‐step regioselective diastereoselective cycloenlargement in form semipinacol‐type rearrangement. In particular, desired...
This perspective highlights recent advances and provides an outlook on future developments in the first-row transition metal catalysed enantioconvergent radical Suzuki–Miyaura C(sp 3 )−C coupling of racemic alkyl halides.
Abstract A novel oxidative CS bond cleavage reaction of DMSO for dual CC and CN formation is described. series acetyl heteroarenes could be selectively converted into the corresponding β‐amino ketones, which are frequently found in biologically active compounds pharmaceuticals. acted this not only as solvent but also a one‐carbon bridge.
A novel photocatalyst-free visible-light-mediated dithioacetalization of aldehydes and thiols has been developed.
Abstract The copper‐catalyzed enantioconvergent radical C(sp 3 )−C(sp 2 ) cross‐coupling of tertiary α‐bromo‐β‐lactams with organoboronate esters could provide the synthetically valuable α‐quaternary β‐lactams. challenge arises mainly from construction sterically congested quaternary stereocenters between alkyl radicals and chiral copper(II) species. Herein, we describe our success in achieving such transformations through utilization a copper/hemilabile N,N,N‐ligand catalyst to forge bond...