A5057162340- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Perovskite Materials and Applications
- Hip and Femur Fractures
- Opioid Use Disorder Treatment
- Bone Metabolism and Diseases
- Nutrition and Health in Aging
- Algal biology and biofuel production
- Genomic variations and chromosomal abnormalities
- Musculoskeletal pain and rehabilitation
- Plant responses to elevated CO2
- Suicide and Self-Harm Studies
- Pain Management and Opioid Use
- Spine and Intervertebral Disc Pathology
- Nerve injury and regeneration
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Spinal Fractures and Fixation Techniques
- Genomics and Chromatin Dynamics
- Luminescence Properties of Advanced Materials
- Epigenetics and DNA Methylation
Kunming Medical University
2016-2025
Yunnan Provincial Department of Education
2025
Kunming University of Science and Technology
2022-2024
First People's Hospital of Yunnan Province
2020-2024
Sixth Affiliated Hospital of Kunming Medical University
2016-2022
Yunnan University
2022
Biocon (Switzerland)
2022
Xiaomi (China)
2022
Second Affiliated Hospital of Kunming Medical College
2016
Harbin Medical University
2011
Tissue engineered bracket materials provide essential support for the physiological protection and therapeutics of patients. Unfortunately, implantation process such devices poses risk surgical complications infection. In this study, an upconversion nanoparticles (UCNPs)-assisted 3D bioprinting approach is developed to realize in vivo molding that free from invasive surgery. Reasonably designed UCNPs, which convert near-infrared (NIR) photons penetrate skin tissues into blue-violet emission...
Abstract Background Melatonin (MT), ubiquitous in almost all organisms, functions as a free radical scavenger. Despite several reports on its role an antioxidant animals, plants, and some microorganisms, extensive studies filamentous fungi are limited. Based upon the of melatonin antioxidant, we investigated heavy metal-induced stress tolerance Exophiala pisciphila , dark septate endophyte (DSE), by studying underlying mechanisms alleviating oxidative reducing metal accumulation. Results A...
Abstract Immunocytes dynamically reprogram their gene expression profiles during differentiation and immunoresponse. However, the underlying mechanism remains elusive. Here, we develop a single-cell Hi-C method systematically delineate 3D genome dynamic epigenetic atlas of macrophages these processes. We propose “degree disorder” to measure organizational patterns inside topologically-associated domains, which is correlated with chromatin states, expression, structure variability in...
Abstract Mechanoluminescence (ML) has always attracted much attention due to the broad prospects in various fields. However, types of ML materials are still limited. Here, traps introduced by means X‐ray irradiation, and finally a high brightness visible naked eye during daytime 20 s afterglow is obtained Cs 2 HfCl 6 : Te 4+ Inorganic Lead‐free halide perovskites (ILFHPs). This work will promote further development provide way thinking for exploration new materials.
Bioimaging with remarkable noninvasive nature, ultrahigh resolution and sensitivity allows detection of pathologies bones, organs, tissues. Nevertheless, the achievement more complete information in vivo is challenged by necessity multiple photodetectors diverse response ranges. Herein, a multifunctional bioimaging Cs 2 AgInCl 6 :Yb 3+ perovskites via single InGaAs detector for superior tissue presentation realized this work. Co‐incorporation foreign dopant contributes to alterations local...
Transplantation of bone-marrow-derived mesenchymal stem cells (MSCs) has been used to treat spinal cord injury (SCI) enhance tissue repair and neural cell regeneration. Glial line derived neurotrophic factor (GDNF) is an identified growth survival factor. Here, we examined whether modification GDNF levels in MSCs may further increase the potential promoting regeneration subsequently therapeutic outcome.We mRNA protein human by RT-qPCR Western blot, respectively. Bioinformatics analyses were...
Cs3Cu2I5 nanocrystals (NCs) are considered to be promising materials due their high photoluminescence efficiency, lack of lead toxicity, and X-ray responsiveness. However, during the crystallization process, NCs prone agglomeration exhibit uneven size distribution, resulting in several light scattering that severely affect imaging resolution. Herein, we successfully developed a high-resolution scintillator film by growing copper-based perovskite within hybrid polymer matrix. By leveraging...
Abstract: Adverse skin reactions caused by the COVID-19 vaccine have attracted considerable attention. As we all know, development mechanism of some diseases is related to gut and microbiome. A 78-year-old male patient who received developed generalized eczema with multiple dense black patches over body, a widespread rash, erosion, scabs on his limbs, as well facial edema. The experienced recurrent flare-ups after conventional treatment, but then recovered without recurrence undergoing three...
Abstract This study delves into the correlation between childhood trauma and non-suicidal self-injury (NSSI) behaviors among high school students. Additionally, it examines mediating role of stress perception moderating teacher-student relationship in this association. A questionnaire survey was administered to 1,329 students Yunnan Province assess trauma, NSSI behaviors, perception. Firstly, revealed a 12% prevalence NSSI, with girls exhibiting higher occurrence compared boys (OR = 0.413,...
Mechanical sensors execute multi-mode response to external force, which are cornerstones for applications in human-machine interactions and smart wearable equipments. Nevertheless, an integrated sensor responding mechanical stimulation variables providing the information of corresponding signals, as velocity, direction, stress distribution, remains a challenge. Herein, Nafion@Ag@ZnS/polydimethylsiloxanes (PDMS) composite is explored, realizes description action via optics electronics signals...
Osteoporosis is a systemic bone metabolic disease that highly prevalent in the elderly population, particularly postmenopausal women, which results enhanced fragility and an increased susceptibility to fractures. However, underlying molecular pathogenesis mechanisms still remain be further elucidated. In this study, rat ovariectomy- (OVX-) induced osteoporosis model, aberrant expression of microRNA miR-142-5p vascular cell adhesion molecule 1 (VCAM-1) was found by RNA sequencing analysis...
BACKGROUND:Colon adenocarcinoma mostly happens at the junction of rectum and is a common gastrointestinal malignancy. Accumulated evidence has indicated that colon develops by genetic alterations complicated disease. The aim this study was to screen differentially expressed miRNAs (DEMs) genes with diagnostic prognostic potentials in adenocarcinoma. MATERIAL AND METHODS:In we screened DEMs their target (DEGs) between 100 normal samples Cancer Genome Atlas (TCGA) database using DEseq toolkit...
Treatment‑resistant schizophrenia (TRS) is a common phenotype of that places considerable burden on patients as well society. TRS known for its tendency to relapse and uncontrollable nature, with poor response antipsychotics other than clozapine. Therefore, it urgent identify objective biological markers, so guide treatment associated clinical work. In the present study, peripheral blood mononuclear cells (PBMCs) healthy control group, which were gender‑, age‑ ethnicity‑matched, subjected...
Osteoporosis is a metabolic bone disease characterized by decrease in mass and degradation of the microstructure, which increases fragility risk fracture. However, molecular mechanisms osteoporosis remain unclear. The current study attempts to elucidate role exosomal long non-coding RNA pathology osteoporosis. Peripheral blood was collected from persons with (OP) or without (NC) osteoporosis, serum exosomes were extracted using ultra centrifugation process. Total isolated, lncRNAs profiling...
The differentiation imbalance in bone marrow mesenchymal stem cells (BMMSCs) is critical for the development of density diseases as population ages. BMMSCs are precursor osteoblasts and adipocytes; however, chromatin organization landscapes during BMMSC remain elusive. In this study, we systematically delineate four-dimensional genome dynamic epigenetic atlas by RNA sequencing, assay transposase-accessible high-throughput chromosome conformation capture. structure analyses reveal 17.5%...
Abstract This research conducted a two‐sample univariate and multivariate Mendelian Randomization (MR) analysis to explore the causal link between different types of leisure sedentary behavior (LSB) frailty. Independent instrumental variables significantly associated with behaviors ( p < 5 × 10 −8 ) are obtained from genome‐wide association study (GWAS) 422,218 individuals, Frailty Index (FI) derived latest GWAS dataset 175,226 individuals. MR is using inverse variance weighting,...
With aging, an imbalance in bone remodeling leading to increased resorption and decreased formation is thought contribute osteoporosis. Osteoblastic differentiation of marrow mesenchymal stem cells (BMMSCs) plays a vital role the pathogenesis However, detailed molecular mechanisms osteoporosis remain incompletely understood. Given that long non-coding RNA taurine upregulated gene 1 (lnc TUG1) critical osteogenic differentiation, microRNA-23b (miR-23b) as putative sponge for lnc TUG1 has...
The objective of this study was to analyze the clinical characteristics and therapeutic effects treatment at our spinal center in OVCF patients associated with referred pain. underlying goals were deepen understanding pain caused by OVCFs, improve currently low early diagnosis rate effectiveness treatment.
Understanding neurite outgrowth, orientation, and migration is important for the design of biomaterials that interface with neural tissue. However, molecular signaling alternations have not been well elucidated to explain impact hydrogels on cell morphology. In our previous studies, a silk fibroin peptide (SF16) hydrogel was found be an effective matrix viability, morphology, proliferation PC12 rat pheocrhomocytoma cells. We cells in exhibited adhesive morphology compared those cultured...
Abstract Human mesenchymal stem cells (hMSCs) are fibroblastoid multipotent adult with capacities of differentiation into osteoblasts and chondrocytes show great potential in new bone formation repair‐related clinical settings, such as osteoporosis. Long noncoding RNAs (lncRNAs) have been demonstrated to play important roles various biological processes. Here, we report an antisense lncRNA SEMA3B‐AS1 regulating hMSCs osteogenesis. is proximal a member the semaphorin family Sema3b....