A5074951205- Histone Deacetylase Inhibitors Research
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Genetics, Bioinformatics, and Biomedical Research
- Multiple Myeloma Research and Treatments
- Sepsis Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Drug-Induced Hepatotoxicity and Protection
- Malaria Research and Control
- CRISPR and Genetic Engineering
- Family and Patient Care in Intensive Care Units
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Neonatal and Maternal Infections
- Neutropenia and Cancer Infections
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Chronic Myeloid Leukemia Treatments
- Nosocomial Infections in ICU
- Transplantation: Methods and Outcomes
Texas Children's Hospital
2018-2024
Baylor College of Medicine
2022-2024
University of Pennsylvania Health System
2022-2023
University of Maryland, College Park
2023
Memorial Sloan Kettering Cancer Center
2014-2020
SSM Health Care
2020
Cincinnati Children's Hospital Medical Center
2016-2018
Kettering University
2018
Hospital Research Foundation
2017
George Washington University
2017
Pancreatic adenocarcinoma (PAC) is part of several cancer predisposition syndromes; however, indications for genetic counseling/testing are not well-defined. In the current study, authors sought to determine mutation prevalence and characteristics that predictive an inherited PAC.A total 175 consecutive patients with PAC who underwent clinical genetics assessment at Memorial Sloan Kettering Cancer Center between 2011 2014 were identified. Clinical data, family history, germline results...
Somatic mutations affecting ETV6 often occur in acute lymphoblastic leukemia (ALL), the most common childhood malignancy. The genetic factors that predispose to ALL remain poorly understood. Here we identify a novel germline p. L349P mutation kindred affected by thrombocytopenia and ALL. A second N385fs was identified an unrelated characterized thrombocytopenia, secondary myelodysplasia/acute myeloid leukemia. Leukemic cells from proband showed deletion of wild type with retention N385fs....
BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity data exists on the pathology cancers (BCs) in men BRCA1/2 mutations. Using largest available dataset, we determined whether MBCs arising mutation carriers display specific pathologic features and these differ from those female BCs (FBCs). We characterised 419 using logistic regression analysis, contrasted 9675 FBCs population-based 6351 Surveillance, Epidemiology,...
Artemisia annua hot water infusion (tea) has been used in vitro experiments against P. falciparum malaria parasites to test potency relative equivalent pure artemisinin. High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed determine the metabolite profile of tea including concentrations artemisinin (47.5±0.8 mg L-1), dihydroartemisinic acid (70.0±0.3 arteannuin B (1.3±0.0 isovitexin (105.0±7.2 L-1) a range polyphenolic acids. The extract, purified...
Given the frequent and largely incurable occurrence of multiple myeloma, identification germline genetic mutations that predispose cells to myeloma may provide insight into disease etiology developmental mechanisms its cell origin, plasma (PC). Here, we identified familial early-onset kindreds with truncating in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor primarily demethylates histone H3 on lysine 4 regulates hematopoietic stem self-renewal. In...
We report an improved, nonhazardous, high-throughput assay for in vitro quantification of antimalarial drug inhibition β-hematin (hemozoin) crystallization performed under conditions that are more physiological relative to previous assays. The uses the differential detergent solubility crystalline and noncrystalline forms heme is optimized via use lipid catalyst. Using this assay, we quantify effect pH on crystal growth-inhibitory activities current quinoline antimalarials, evaluate...
Abstract Background Drug combination therapy is the frontline of malaria treatment. There an ever-accelerating need for new, efficacious therapies active against drug resistant malaria. Proven drugs already in treatment pipeline, such as quinolines, are important components current and also present attractive test bank rapid development new concepts. Methods The efficacy several combinations versus chloroquine-sensitive chloroquine-resistant strains was measured using both cytostatic...
Abstract Pediatric sepsis and bacterial infection cause significant morbidity mortality worldwide, with immunocompromised patients being at particularly high risk of rapid deterioration death. This study evaluated if PERSEVERE, PERSEVERE-II, or the PERSEVERE biomarkers, can reliably estimate clinical 28-day among pediatric patients. is a single-center prospective cohort conducted from July 2016 through September 2017 incorporating 400 episodes suspected inpatient units Cincinnati Children’s...
Artemisia annua hot water infusion (tea) has been used in vitro experiments against P. falciparum malaria parasites to test potency relative equivalent pure artemisinin.High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed determine the metabolite profile of tea including concentrations artemisinin (47.5±0.8 mg L -1 ), dihydroartemisinic acid (70.0±0.3 arteannuin B (1.3±0.0 isovitexin (105.0±7.2 ) a range polyphenolic acids.The extract, purified...
Abstract Background To evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) determine dosimetric clinical consequences. Methods Eighty-five patients with 510 computed tomography (CT) images were analyzed. Median prescription dose was 40 Gy 5 fractions. Patients instructed to maintain a full empty prior simulation each treatment. A single reviewer delineated organs at risk (OARs) on the (Sim-CT) Cone Beam CTs (CBCT) for...
Abstract The prevalence of celiac disease ( CD ) is increasing and may be as high 1% the US population. typical presentation generally includes gastrointestinal symptoms, but more individuals are presenting with extraintestinal manifestations. A wide variety dermatologic associations have been described , including alopecia, dermatitis herpetiformis, enamel hypoplasia. In this report we describe three girls who presented hypopigmented skin lesions pruritus in perivaginal perianal areas,...
Few reports of educational and counseling support resources exist for Lynch syndrome (LS), a disorder requiring multi-organ cancer screening specialized medical care throughout adult life. Here we describe the development efficacy two designed to address this need, Memorial Sloan Kettering Cancer Center Clinical Genetics Service annual Syndrome Educational Workshop (LSEW), quarterly Patient Advocacy Network (LSPAN) group. The LSEW LSPAN were implemented beginning in 2012. Participant survey...
Background Immunocompromised pediatric patients constitute a growing population that is particularly vulnerable to bacterial infection, necessitating prompt recognition and treatment. This study assessed the utility of interleukin-27 (IL-27) procalcitonin (PCT) as biomarkers infection among immunocompromised subjects. Methods single-center prospective cohort conducted from July 2016 through September 2017, drawing subjects inpatient units at Cincinnati Children's Hospital Medical Center...
COVID-19 convalescent plasma (CCP) represents an appealing approach to the treatment of patients with infections due SARS-CoV-2. We endeavored quickly establish a sustainable CCP transfusion program for regional network health care facilities.A collaborative group was activated address issues necessary implementing and making sustainable. A wide range providers including physicians (critical care, infectious disease, medicine), nurses, pharmacists, laboratorians, information technology (IT)...
ABSTRACT Background Pediatric solid organ transplantation is challenging due to the limited availability of suitable organs resulting in an increasing waitlist. Many pediatric transplant recipients receive from deceased donors, often after neurologic determination death. Organ donation patients on extracorporeal membrane oxygenation (ECMO) at time death has been described adults, offering potential for circulatory (DCDD) with minimal ischemia time. Case Description DCDD ECMO requires a...
You have accessJournal of UrologyKidney Cancer: Evaluation/Staging II1 Apr 2014MP30-12 RENAL CELL CARCINOMA AND NON-HODGKIN’S LYMPHOMA: GENOMIC APPROACHES TO IDENTIFICATION OF SHARED SUSCEPTIBILITY Kelly Stratton, Kasmintan Schrader, Christopher Manschreck, Rohini Rau-Murthy, Marina Corines, Lauren Jacobs, Janice Dutcher, Peter Wiernik, M. Lia Palomba, Carol Portlock, Rajmohan Murali, Robert Klein, Jonathan Coleman, Zsofia Stadler, Kenneth Offit, and Vijai Joseph StrattonKelly Stratton ,...
The purpose of this study was to assess the feasibility hospital-wide implementation an above-cuff vocalization (ACV) protocol using ACV-capable tracheostomy tubes and its impact on patient speech in four intensive care unit (ICU) populations.