A5103920943- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Bacteriophages and microbial interactions
- Respiratory and Cough-Related Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Data-Driven Disease Surveillance
- vaccines and immunoinformatics approaches
- COVID-19 epidemiological studies
- Indian Economic and Social Development
- Health Literacy and Information Accessibility
- HIV/AIDS Research and Interventions
- Biosimilars and Bioanalytical Methods
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Global Maternal and Child Health
- Tracheal and airway disorders
- Global trade and economics
University of Ghana
2016-2025
Korle Bu Teaching Hospital
2011-2024
Mycobacterium africanum comprises two phylogenetic lineages within the M. tuberculosis complex (MTBC) and is an important cause of human (TB) in West Africa. The reasons for this geographic restriction remain unclear. Here, we performed a prospective study to explore associations between characteristics TB patients MTBC circulating Ghana.We genotyped 1,211 isolates recovered from pulmonary recruited 2012 2014 using single nucleotide polymorphism typing spoligotyping. Associations patient...
Drug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. 2008, new research network, African Network Excellence for Tuberculosis, AIDS Malaria (WANETAM), founded, comprising nine study sites from eight countries (Burkina Faso, The Gambia,...
Abstract Mycobacterium africanum ( Maf) causes a substantial proportion of human tuberculosis in some countries West Africa, but little is known on this pathogen. We compared the genomes 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and 78 6 (L6). found that genomic diversity L6 was higher than L5 despite smaller sample size. Regulatory proteins appeared to evolve neutrally under purifying selection L6. Even though over 90% T cell epitopes were conserved both...
ObjectiveUnderstanding transmission dynamics is useful for tuberculosis (TB) control. A population-based molecular epidemiological study was conducted to determine TB in Ghana.MethodsMycobacterium complex (MTBC) isolates obtained from prospectively sampled pulmonary patients between July 2012 and December 2015 were characterized using spoligotyping standard 15-locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) typing studies.ResultsOut of 2309 MTBC...
Journal Article Factors associated with mortality and default among patients tuberculosis attending a teaching hospital clinic in Accra, Ghana Get access Nicole T. Burton, Burton ⁎ aDepartment of Community Health, Warren Alpert Medical School at Brown University, Box GS121, 121 South Main Street, Providence, RI 02906, Rhode Island 02912 USA ⁎Corresponding author. Tel.: +1 978 857 0078; fax: 401 793 4704. E-mail address:nicole_burton@brown.edu (N.T. Burton). Search for other works by this...
Background Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M. strains with hyper-virulence, MDR-TB disseminated disease makes it imperative to understand the biology pathogen. Methods (15) among 1755 complex (MTBC) isolated between 2012 2014 were characterized analyzed for associated patient demography other risk factors. Five isolates whole-genome sequenced comparatively against global collection...
The incidence of Tuberculosis (TB) differs among countries and contributes to morbidity mortality especially in the developing countries. Trends seasonal changes number patients presenting with TB have been studied worldwide including sub-Saharan Africa. However, these are unknown at Korle-Bu Teaching Hospital (KBTH). aim this study was obtain a time series model estimate cases chest clinic hospital.A analysis using Box-Jenkins approach propounded as an autoregressive moving average (ARIMA)...
Whole genome sequencing (WGS) is progressively being used to investigate the transmission dynamics of Mycobacterium tuberculosis complex (MTBC). We WGS analysis resolve traditional genotype clusters and explored spatial distribution confirmed recent clusters. Bacterial genomes from a total 452 MTBC isolates belonging large population-based study spanning July 2012 December 2015 were obtained through short read next-generation using illumina HiSeq2500 platform. performed clustering specified...
Tuberculosis (TB) and HIV are strongly linked. There is a 19 times increased risk of developing active TB in people living with than HIV-negative Sub-Saharan Africa being the hardest hit region. According to WHO, 1.3 million died from TB, an additional 300,000 TB-related deaths among HIV. Although some progress has been made reducing due evolution diagnostics, treatment antiretroviral treatment, multi drug resistant becoming source worry. Though significant at national level, understanding...
Computer-aided detection (CAD) systems hold promise for improving tuberculosis (TB) on digital chest x-rays (dCXR).However, data their performance in exclusively paediatric populations are scarce.We conducted a retrospective diagnostic accuracy study evaluating the of CAD TB version 7 (CAD4TBv7 ® ) using dCXR from well-characterised cohorts Gambian children younger than 15 years with presumed pulmonary TB.The were consecutively recruited between 2012 and 2022.We measured CAD4TBv7 against...
Abnormalities in lung function tests have been shown to commonly occur a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern these abnormalities described other populations but this is unknown among our cohort. There generally little information available on risk factors associated the its relevance patient care. This was an analytical cross-sectional study involving 76 clinically stable, hydroxyurea-naive adult Hb-SS participants nonsickle...
Background Diabetes Mellitus (DM) is a known risk factor for tuberculosis (TB) but little on TB-Diabetes (TBDM) co-morbidity in Sub-Saharan Africa. Methods Consecutive TB cases registered at tertiary facility Ghana were recruited from September 2012 to April 2016 and screened DM using random blood glucose glycated hemoglobin (HbA1c) level. patients tested other clinical parameters including HIV co-infection lesion location. Mycobacterial isolates obtained collected sputum samples...
Asthma as a chronic health condition can be controlled when in addition to clinical care, adequate education and support is provided enhance self-management. Like many other conditions improved self-management positively impacts the health-related quality of life (HRQoL). It therefore said that well-structured pharmaceutical care delivery addresses issues related patient towards stands good chance impacting asthma control. This study evaluated impact structured on control.A prospective...
Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for (TB) therapy, especially among previously treated patients. We aimed investigate frequency and pattern patients with smear-positive pulmonary at Korle-Bu Teaching Hospital Chest Clinic, Accra. This was cross-sectional survey mycobacterial isolates from referred Clinic Laboratory between October 2010 2013. The Bactec MGIT 960 system mycobactrerial culture sensitivity testing (DST) used...
Background: Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug among diverse primary drug-resistant Mycobacterium complex (MTBC) isolates in Ghana. Materials and methods: One hundred seventeen MTBC with varying first-line were analyzed. Additional drugs (streptomycin [STR], amikacin [AMK] moxifloxacin [MOX]) profiled using Etest GenoType MTBDRsl version 2.0. Genes associated AMK MOX ( gyrA ,...
Despite advancements made toward diagnostics, tuberculosis caused by Mycobacterium africanum (Maf) and sensu stricto (Mtbss) remains a major public health issue. Human host factors are key players in (TB) outcomes treatment. Research is required to probe the interplay between bacterial genomes. Here, we explored association selected human/host genomic variants TB disease Ghana. Paired genotype datum infecting isolate information were analyzed for associations using multinomial logistic...
Introduction: high mortality among individuals receiving retreatment for tuberculosis (RT-TB) persists, although reasons these poor outcomes remain unclear.
Background Multidrug-resistant tuberculosis (MDR-TB) remains a clear threat to TB control. There is paucity of data on DR-TB for many countries especially in sub-Saharan Africa. The study was undertaken measure the prevalence DR-TB, including MDR-TB, from West Methods Mycobacterial isolates were obtained consecutive new and previously treated patients Burkina Faso, Ghana, Guinea-Bissau, Mali, Nigeria, Senegal, Gambia Togo December 2012 2014. Phenotypic drug susceptibility testing first-...
ObjectiveTo retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015.MethodsMycobacterium complex isolates obtained rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, phylogenetic analysis carried out to assess strain relatedness.ResultsThe majority (58.3%, 21/36) episodes had recurrence within 12...
Pulmonary hypertension (PH) has become an increasingly recognized complication in sickle cell anaemia (SCA) and is a major cause of morbidity mortality. Though the burden SCA sub-Saharan Africa high, there paucity data on SCA-associated PH with little or no attention given to it routine patient care. The current study therefore sought determine prevalence its associated risk factors among adult patients SCA. This was cross-sectional involving 76 clinically stable, hydroxyurea-naive...
ObjectiveThis study assessed patients' knowledge of asthma, their level self-management and satisfaction with care at the Korle-Bu Teaching Hospital Adult Asthma Clinic.MethodsThis was a quantitative cross-sectional Clinic in Accra. Sixty-eight (68) clinically diagnosed asthma patients who have been attending clinic regularly for reviews more than six months, were recruited this study. An abridged version Knowledge modified Self-Management Questionnaire used to assess outcome measures...