A5101406310- Natural Compounds in Disease Treatment
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Advanced Photocatalysis Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Drug-Induced Hepatotoxicity and Protection
- Quantum Dots Synthesis And Properties
- Mass Spectrometry Techniques and Applications
- Sperm and Testicular Function
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Electrochemical sensors and biosensors
- Synthesis of Organic Compounds
- Neuroscience and Neural Engineering
- Peroxisome Proliferator-Activated Receptors
- Viral Infections and Immunology Research
- TiO2 Photocatalysis and Solar Cells
- Liver Diseases and Immunity
- Copper-based nanomaterials and applications
- Synthesis and Reactions of Organic Compounds
- Atherosclerosis and Cardiovascular Diseases
- Oral and gingival health research
- Renal cell carcinoma treatment
- Catalytic Processes in Materials Science
- Biosensors and Analytical Detection
Kunming Institute of Botany
2018-2023
Chinese Academy of Sciences
2018-2023
First Affiliated Hospital of Nanchang University
2017-2022
Nanchang University
2017-2022
University of Chinese Academy of Sciences
2018-2020
National Synchrotron Radiation Laboratory
2013
University of Science and Technology of China
2013
Chung Yuan Christian University
2008
Male fertility impaired by exogenous toxins is a serious worldwide issue threatening the health of new-born and causing infertility. However, metabolic connection between toxic exposures testicular dysfunction remains unclear.In present study, disorder was investigated using triptolide-induced injury in mice. We found that triptolide induced spermine deficiency resulting from disruption polyamine biosynthesis uptake testis, perturbation gut microbiota. Supplementation with reversed through...
Sunitinib is a small-molecule TK inhibitor associated with hepatotoxicity. The mechanisms of its toxicity are still unclear.In the present study, mice were treated 60, 150, and 450 mg·kg-1 sunitinib to evaluate metabolites endogenous in liver, serum, faeces, urine analysed using ultra-performance LC electrospray ionization quadrupole time-of-flight MS-based metabolomics.Four reactive impaired clearance liver played dominant role sunitinib-induced Using non-targeted metabolomics approach,...
Abstract Triptolide (TP), one of the main active ingredients in Tripterygium wilfordii Hook F, is clinically used to treat immune diseases but known cause liver injury. The aim this study was investigate biomarkers for TP-induced hepatotoxicity mice and determine potential mechanisms its LC/MS-based metabolomics metabolites that were changed accumulation long-chain acylcarnitines serum indicated TP exposure disrupted endogenous peroxisome proliferator-activated receptor α (PPARα) signaling....
Abstract Triptolide (TP), one of the main bioactive diterpenes herbal medicine Tripterygium wilfordii Hook F, is used for treatment autoimmune diseases in clinic and accompanied by severe hepatotoxicity. CYP3A4 has been reported to be responsible TP metabolism, but mechanism remains unclear. The present study applied a UPLC–QTOF–MS‐based metabolomics analysis characterize effect on TP‐induced metabolites carnitines, lysophosphatidylcholines (LPCs) serious amino acids were found closely...
A heating paper spray mass spectrometry method was developed to improve detection of propranolol in dried blood samples.
A series of new isolongifolanonyl pyrazole derivatives 3a～3j were synthesized by aldol-condensation, cyclization and dehydroaromatization from isolongifolanone.The yields products ranged 69.5% to 76.5%.The chemical structures compounds obtained elucidated 1 H NMR, 13 C IR, MS spectra elemental analysis.The strucure compound 3i was determined X-ray single crystal diffraction.Their inhibitory activities against human hepatoma cell (HepG2) umbilical vein endothelial (HUVECs) evaluated.The...
The local structures of Mo-doped TiO2 photocatalysts are investigated by X-ray absorption fine structure spectroscopy (XAFS) combined with diffraction (XRD). XRD patterns show that all the samples maintain high qualitative anatase without any visible peak related to Mo. detailed XANES and EXAFS analysis reveal Mo atoms substitute Ti in lattice as Mo6+ doping concentration 6 atom %. Combined theoretical calculation, we suggested electron density Mo-O causes strong shrinkage ~0.1 Å for bond...
Myocarditis is a complex disease characterized by myocardial inflammatory cell infiltration. The purpose of our study was to investigate the gene and single-cell signature explore involvement immune cells in myocarditis. Gene expressions merged from GSE35182 datasets were subjected differential expression (DEG) analysis PPI network construction. correlation DEGs with infiltration performed. Single-cell RNA sequencing (scRNA-seq) downloaded GSE174458. A total 58 identified, including 51...
A miniaturized wireless glucose biosensor has been developed to performin vitro and in vivo studies. It consists of an external control subsystem implant sensing subsystem. The a micro-processor, which coordinates circuitries radio frequency, power regulator, command demodulator, trigger signal read-out. Except for set electrodes, the receiving coil were hermetically sealed with polydimethylsiloxane. electrode is substrate silicon oxide coated platinum, includes working reference electrode....
Determining the local structure of dopant atoms is critical for understanding mechanism enhanced photoelectrochemical activity in doping-modified semiconductor photoelectrodes. Here, we have synthesized Fe-doped Co3O4 nanowire arrays photoanodes on Ti foil and detected role Fe via X-ray absorption fine (XAFS) spectra electrochemical impedance measurements. The XAFS analysis shows that dopants are doped into occupy octahedral sites. Coupling with Co at sites, significantly increases carrier...