A5020043757- Systemic Sclerosis and Related Diseases
- Infrared Thermography in Medicine
- Veterinary Equine Medical Research
- Dermatologic Treatments and Research
- Thermoregulation and physiological responses
- Effects of Environmental Stressors on Livestock
- Thermography and Photoacoustic Techniques
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Skin Diseases and Diabetes
- Exercise and Physiological Responses
- Meat and Animal Product Quality
- Inflammatory Myopathies and Dermatomyositis
- Dupuytren's Contracture and Treatments
- Photoacoustic and Ultrasonic Imaging
- Laser Applications in Dentistry and Medicine
- Lymphatic System and Diseases
- Bee Products Chemical Analysis
- Diagnosis and Treatment of Venous Diseases
- Dermatological and COVID-19 studies
- Sports Performance and Training
- Thermal Regulation in Medicine
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Function and Risk Factors
- Calibration and Measurement Techniques
University College London
2015-2024
The Royal Free Hospital
2015-2024
Birmingham City Council
2023
Royal Free London NHS Foundation Trust
2016-2022
University College London Hospitals NHS Foundation Trust
2018
Institute of Infection and Immunity
2015-2017
Salford Royal Hospital
2015
University of Manchester
2015
University of Leeds
2012
NIHR Leeds Musculoskeletal Biomedical Research Unit
2012
To compare the efficacy and tolerability of losartan, an antagonist angiotensin II receptor type 1, with nifedipine for treatment primary secondary Raynaud's phenomenon (RP) in a pilot study.In randomized, parallel-group, controlled trial, patients RP (n = 25) or to systemic sclerosis (SSc [scleroderma]; n 27) were allocated receive 12 weeks' either losartan (50 mg/day) (40 mg/day). Primary outcome variables severity frequency episodes findings on vascular measurements, including...
Objective. To compare fluoxetine, a selective serotonin reuptake inhibitor, with nifedipine as treatment for primary or secondary Raynaud's phenomenon. Methods. Twenty‐six patients and 27 phenomenon were assigned randomly to receive 6 weeks of fluoxetine (20 mg daily) (40 daily). Following 2‐week washout period, each group was crossed over the other arm. The outcome variable frequency attacks Self‐reported attack severity, thermographic recovery from cold challenge plasma levels von...
Abstract The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that pericytes constitute a cellular link between and transdifferentiating into myofibroblasts. used combination of immunohistochemistry double immunofluorescence labelling frozen skin biopsies taken from normal dcSSc patients determine whether phenotypic myofibroblasts exists dcSSc. Using α-smooth muscle actin, the ED-A splice variant...
Background Localized scleroderma (LS) or morphoea is often considered to be a benign self-limiting condition confined the skin and subcutaneous tissue. However, course of disease unpredictable severe functional cosmetic disability may result. Drug treatment with systemic corticosteroids in combination methotrexate has been reported beneficial LS, but data children limited. Objectives To evaluate efficacy tolerability LS. Methods Treatment outcome 34 patients LS were retrospectively analysed....
Objective Reliable and objective outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis ( SS c)–related Raynaud's phenomenon RP ) are badly needed. Laser speckle contrast imaging LSCI thermography noninvasive perfusion that have shown excellent potential. This multicenter study was undertaken determine the reliability validity a hand cold challenge protocol using , standard thermography, low‐cost cell phone/mobile phone (henceforth referred as mobile...
Abstract Objective Assessment of disease activity is a major challenge in the management children with localized scleroderma. The aim this study was to evaluate role laser Doppler flowmetry (LDF) comparison infrared thermography detection scleroderma activity. Methods In 41 scleroderma, 111 lesions were assessed on 2 separate occasions, by clinical examination, LDF, and thermography. Measurements from contralateral areas unaffected skin served as intrapatient controls, differences blood flow...
We identified and clinically investigated two patients with primary erythromelalgia mutations (PEM), which are the first reported to map fourth domain of Nav1.7 (DIV). The (A1746G W1538R) were cloned transfected cell cultures followed by electrophysiological analysis in whole-cell configuration. presented PEM, while age onset was very different (3 vs. 61 years age). Electrophysiological characterization revealed that early A1746G mutation leads a marked hyperpolarizing shift voltage...
Nailfold capillaroscopy is being increasingly used by rheumatologists in the diagnosis of SSc. However, assessment all nailfolds can be time-consuming a busy outpatient clinic. Our aim was to answer question as how many (and which) fingers clinician should routinely assess capture accurately true state.A total 2994 assessments (by an international panel expert observers) 1600 images from 173 participants (101 with SSc, 22 primary RP and 50 healthy controls) were included this analysis. Seven...
Raynaud's phenomenon (RP) is a common condition and causes pain, paraesthesia, ulceration gangrene. Botulinum toxin A (Btx-A) effective when injected via digital palmar approach, in the treatment of severe RP. However, hand weakness resulting from lumbrical malfunction recognized complication. This study aimed to determine effect Btx-A dorsal approach. Forty patients received 100 units Btx-A, across both hands Each patient had baseline, 6- 12-week assessment thermographic image (FLIR E60bx)...
Background/purpose: Localised scleroderma (LS) is the most common form of seen in children, and usually presents unilaterally. Infrared thermography (IRT) laser Doppler (LD) have both been reported to be useful assessing active, inflammatory stage LS. We developed validated a protocol using these techniques for assessment unilateral LS activity children. Method: investigated spatial variability repeatability LD measurements from adult control forearm skin, inter‐ intra‐operator...