A5027130627- Advanced MRI Techniques and Applications
- Systemic Sclerosis and Related Diseases
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Digital Radiography and Breast Imaging
- Dermatologic Treatments and Research
- Head and Neck Cancer Studies
- Ultrasound and Hyperthermia Applications
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lymphatic System and Diseases
- Infrared Thermography in Medicine
- Diagnosis and Treatment of Venous Diseases
- Autoimmune Bullous Skin Diseases
- Photoacoustic and Ultrasonic Imaging
- Medical Image Segmentation Techniques
- Inflammatory Myopathies and Dermatomyositis
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Atomic and Subatomic Physics Research
- Body Contouring and Surgery
- Ultrasound Imaging and Elastography
- Digital Imaging for Blood Diseases
Manchester Academic Health Science Centre
2025
University of Manchester
2016-2025
Cancer Research UK Manchester Institute
2023-2024
Salford Royal Hospital
2015
University College London
2015
Hospital of Southern Norway
2015
Institute of Population and Public Health
2015
Abstract Objectives Nailfold capillaroscopy is key to timely diagnosis of SSc, but often not used in rheumatology clinics because the images are difficult interpret. We aimed develop and validate a fully automated image analysis system fill this gap. Methods mimicked interpretation strategies SSc experts, using deep learning networks detect each capillary distal row vessels make morphological measurements. combined measurements from multiple fingers give subject-level probability SSc....
Mammographic density is an important risk factor for breast cancer. In recent research, percentage assessed visually using visual analogue scales (VAS) showed stronger prediction than existing automated measures, suggesting readers may recognize relevant image features not yet captured by hand-crafted algorithms. With deep learning, it be possible to encapsulate this knowledge in automatic method. We have built convolutional neural networks (CNN) predict VAS scores from full-field digital...
The autoimmune disease systemic sclerosis (SSc) causes microvascular changes that can be easily observed cutaneously at the finger nailfold. Optoacoustic imaging (OAI), a combination of optical and ultrasound imaging, specifically raster-scanning optoacoustic mesoscopy (RSOM), offers non-invasive high-resolution 3D visualization capillaries allowing for better view an extraction volumetric measures. In this study, nailfold patients with SSc healthy controls are imaged compared each other...
Pneumonia is a common infection in people suffering with Alzheimer's disease, leading to delirium, critical illness or severe neurological decline, which may be due an amplified response of the blood-brain barrier (BBB) peripheral insult. We assess BBB repeated Streptococcus pneumoniae lung rat model disease (TgF344-AD), at 13- and 18-months old, using dynamic contrast-enhanced (DCE) MRI filter exchange imaging. Higher water rate initially detected infected TgF344-AD rats. rates correlated...
Despite increasing interest in nailfold capillaroscopy, objective measures of capillary structure and blood flow have been little studied. We aimed to test the hypothesis that structural measurements, flow, a combined measure predictive power separate patients with systemic sclerosis (SSc) from those primary Raynaud's phenomenon (PRP) healthy controls (HC). 50 SSc, 12 PRP, HC were imaged using novel capillaroscopy system generates high-quality images provides fully-automated measurements...
Nailfold capillaroscopy is being increasingly used by rheumatologists in the diagnosis of SSc. However, assessment all nailfolds can be time-consuming a busy outpatient clinic. Our aim was to answer question as how many (and which) fingers clinician should routinely assess capture accurately true state.A total 2994 assessments (by an international panel expert observers) 1600 images from 173 participants (101 with SSc, 22 primary RP and 50 healthy controls) were included this analysis. Seven...
Abstract Purpose Software has a substantial impact on quantitative perfusion MRI values. The lack of generally accepted implementations, code sharing and transparent testing reduces reproducibility, hindering the use in clinical trials. To address these issues, ISMRM Open Science Initiative for Perfusion Imaging (OSIPI) aimed to establish community‐led, centralized repository open‐source processing contrast‐based imaging, incorporating an framework. Methods A was established OSIPI GitHub...
Polarisation-sensitive optical coherence tomography (PS-OCT) offers a novel, non-invasive method of assessing skin fibrosis in the multisystem disease systemic sclerosis (SSc) by measuring collagen retardance. This study aimed to assess retardance as biomarker SSc. Thirty-one patients with SSc and 27 healthy controls (HC) underwent PS-OCT imaging. 'Skin score' was assessed clinical palpation (0-3 scale). A subset ten age/sex-matched HC had biopsy longitudinal Histological assessment included...
has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment various tumors. None of the many software tools
Abstract Objectives Universal serial bus (USB) microscopy (capillaroscopy) could provide all rheumatologists with an easy-to-use, low-cost tool to examine the nailfold capillaries facilitate early diagnosis of SSc. The objectives this pilot study were feasibility acquiring and analysing images using USB compare results videocapillaroscopy. Methods Videocapillaroscopy microscope obtained from right left ring fingers 20 patients SSc healthy control subjects. In addition generating panoramic...
A key unanswered question in systemic sclerosis (SSc) is how microvascular abnormality and fibrosis inter-relate. Our aim was to use state-of-the-art non-invasive imaging methods gain new insights into pathophysiology, comparing patients with different subtypes of SSc, including early dcSSc, not only healthy controls but also causes Raynaud's phenomenon progressing fibrosis.
In dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) a sequence of MRI images are acquired to measure the passage contrast-agent within tissue interest.Quantitative DCE-MRI (DCE-MRI), in which one or more tracer-kinetic models fitted concentration time-series, enables estimation clinically useful parameters microvasculature (Tofts et al., 1999).Madym is C++ toolkit for quantitative analysis developed at University Manchester.It comprises set command line tools and graphical...
Tofts models have failed to produce reliable quantitative markers for prostate cancer. We examined the differences between zones and lesion PI-RADS categories grade group (GG) using regions of interest drawn in tumor normal-appearing tissue a two-compartment uptake (2CU) model (including plasma volume (v
Abstract Purpose: Hypoxia mediates treatment resistance in solid tumors. We evaluated if oxygen-enhanced MRI–derived hypoxic volume (HVMRI) is repeatable and can detect radiotherapy-induced hypoxia modification human papillomavirus–associated oropharyngeal head neck squamous cell cancer. Experimental Design: A total of 27 patients were recruited prospectively between March 2021 January 2024. HVMRI was measured primary nodal tumors prior to standard-of-care (chemo)radiotherapy then at weeks 2...
A method has been developed for generating synthetic masses that exhibit the appearance of real breast cancers in mammograms. To be clinically useful, must appear sufficiently realistic, even to expert mammogram readers. This paper presents results an observer study which 10 readers at Nightingale Centre, Manchester attempted distinguish between and synthetically generated masses. Each reader rated a set 30 synthetics on scale ranging from "definitely real" synthetic". ROC curves were fitted...