A5102804356- Carbon and Quantum Dots Applications
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Microfluidic and Capillary Electrophoresis Applications
- Nanoplatforms for cancer theranostics
- Histone Deacetylase Inhibitors Research
- Selenium in Biological Systems
- Redox biology and oxidative stress
- Microfluidic and Bio-sensing Technologies
- Diagnosis and treatment of tuberculosis
- Synthesis of Indole Derivatives
- Urinary and Genital Oncology Studies
- Hematopoietic Stem Cell Transplantation
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Advanced biosensing and bioanalysis techniques
- Metal complexes synthesis and properties
- Bioactive Compounds and Antitumor Agents
- Lipid metabolism and disorders
- Inflammatory mediators and NSAID effects
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
Nanfang Hospital
2024-2025
Guangzhou Medical University
2025
Southern Medical University
2024-2025
Sir Run Run Shaw Hospital
2023
Zhejiang University
2023
Third Affiliated Hospital of Southern Medical University
2022
Wuhan University
2019-2021
Zhongnan Hospital of Wuhan University
2019-2021
Zhejiang Chinese Medical University
2020
Shenzhen Third People’s Hospital
2010-2016
Small-molecule subcellular organelle-targeting theranostic probes are crucial for early disease diagnosis and treatment. The imaging window of these molecules is mainly focused on the visible near-infrared region (below ∼900 nm) which limits tissue penetration depth therapeutic effects. Herein, a novel NIR-II small-molecule probe H4-PEG-Glu with thiopyrylium cation was synthesized. not only can quickly effectively image mitochondria in acute myeloid leukemia (AML) cells, induce G0/G1 phase...
Multicellular aggregates in three-dimensional (3D) environments provide novel solid tumor models that can insight into <italic>in vivo</italic> drug resistance.
Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. PANoptosis, form of programmed cell death merging pyroptosis, apoptosis, and necroptosis, plays an important role in reshaping the microenvironment (TME) enhancing immunotherapy effectiveness. This study investigates PANoptosis dynamics glioma explores therapeutic potential its activation, through natural compounds such as cinobufagin. We comprehensively analyzed...
An acoustic streaming based rapid single-cell drug screening microfluidic device is developed. It achieved by non-invasively changing cell membrane permeability to accelerate absorption in concentration gradient field.
Failure to early detect multidrug-resistant tuberculosis (MDR-TB) results in treatment failure and poor clinical outcomes, highlights the need rapidly resistance rifampicin (RIF) isoniazid (INH).In Multi-Fluorescence quantitative Real-Time PCR (MF-qRT-PCR) assay, 10 probes labeled with four kinds of fluorophores were designed mutations regions rpoB, katG, mabA-inhA, oxyR-ahpC, rrs. The efficiency MF-qRT-PCR assay was tested using 261 bacterial isolates 33 sputum specimens. Among these...
Acute myeloid leukemia (AML) is a hematological malignancy with poor prognosis attributed to elevated reactive oxygen species (ROS) levels. Thus, agents that inhibit ROS generation in AML should be exploited. Azelaic acid (AZA), small molecular compound, can scavenge and other free radicals, exerting antitumor effects on various tumor cells. Herein, this study evaluated the antileukemic activity of AZA against via regulation signaling pathway. We found reduced intracellular levels increased...
Acute myeloid leukemia (AML) is a common type of hematological malignancy that can progress rapidly. AML has poor prognosis and high incidence relapse due to therapeutic resistance. Azelaic acid (AZA), small molecular compound known exhibit antitumor effect on various tumor cells. This study aimed evaluate the antiproliferative immunoregulatory effects AZA against AMLviathe activation notch signaling pathway. We found inhibit proliferation In addition, laser confocal microscopy showed...
Abstract Background: Acute myeloid leukemia (AML) is a hematological malignant tumor. The common chemotherapy results in various side-effect and drug-resistance for AML, so it urgent to find non-toxic natural drug AML therapy. Herein, the first time, Se nanoparticles embedded nanotube consisted of triple helix β-D-glucan (BFP) exhibit high anti-leukemia effects. Methods: A β-(1, 3)-D-glucan extracted from black fungus was self-assembled into water, (SeNPs) were wrapped form stable inclusion...
Objective To explore and analyze the distribution of NAT2 gene in Han population Shenzhen provide basis for treatment NAT2-related metabolic diseases cancer research. Method The study diluted DNA sample(d0 ng/μl) as follows: 1 × 100, 101, 102, ×103 , 104, to verify sensitivity detection polymorphism by real-time PCR. Mutation locus 282,341,481, 590 857 554 normal samples were detected genotyped realtime PCR with Taqman probes. Forty-seven cases among healthy controls sequencing sensitivity,...
Objective: To explore the independent risk factors of infection during intravesical instillation bladder cancer and establish a prediction model, which may reduce probability for patients. Material Methods: 533 patients with newly discovered NMIBC at two hospitals from January 2017 to December 2019 were enrolled in this study. The divided into "infection positive group" negative group". clinical data groups analyzed by logistic regression analyses. Nomogram was generated ROC curve,...
Abstract Hyperleukocytic acute myeloid leukemia (HLL) with high early mortality is difficult to therapy. The related research on HLL still in its infancy, and the establishment of a patient derived xenograft (PDX) model has not been fully reported. In this study, we establish CD34 + hematopoietic stem cell-derived for further exploration. Our findings demonstrated that cells were detected peripheral blood, bone marrow, liver, spleen tissues mice after inoculation patient-derived cells. By...