A5047375568- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Foreign Body Medical Cases
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Esophageal and GI Pathology
- Head and Neck Anomalies
- Parathyroid Disorders and Treatments
- Tracheal and airway disorders
- Retinoids in leukemia and cellular processes
- Myasthenia Gravis and Thymoma
- Cancer and Skin Lesions
- Ubiquitin and proteasome pathways
- Neuroendocrine Tumor Research Advances
- Biochemical and Molecular Research
- Vitamin D Research Studies
- Ear and Head Tumors
- Muscle Physiology and Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Diagnosis and Treatment
- FOXO transcription factor regulation
- HIV/AIDS drug development and treatment
Université de Montpellier
2010-2024
Centre Hospitalier Universitaire de Nîmes
2010-2024
Hospices Civils de Lyon
2024
Université Claude Bernard Lyon 1
2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2021
Institut de Radiobiologie Cellulaire et Moléculaire
2021
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2021
Université de Nîmes
2013-2019
Institut de Recherche en Cancérologie de Montpellier
2017
Inserm
2017
1alpha,25-Dihydroxyvitamin D3 [1,25(OH)2D3] regulates calcium homeostasis and controls cellular differentiation proliferation. The vitamin D receptor (VDR) is a ligand-regulated transcription factor that recognizes cognate response elements (VDREs) formed by direct or everted repeats of PuG(G/T)TCA motifs separated 3 6 bp (DR3 ER6). Here, we have identified 1,25(OH)2D3 target genes combining 35,000+ gene microarrays genome-wide screens for consensus DR3 ER6 elements, containing single...
Context: The preoperative routine measurement of basal serum thyrocalcitonin (CT) in candidates for thyroidectomy due to thyroid nodules is currently a subject debate. Objective: objective this study was evaluate the role systematic CT improving diagnosis and surgical treatment medullary carcinoma (MTC) patients undergoing nodular disorders, regardless levels. Design: We determined levels 2733 consecutive before surgery performed pentagastrin test with hypercalcitoninemia. correlated...
Objectives/Hypothesis To determine the feasibility and preliminary oncological results of transoral robotic surgery (TORS) for treatment early stage laryngeal tumors. Study Design Retrospective single center study. Methods We reviewed medical records 23 patients who underwent TORS T1 or T2 squamous cell carcinoma between August 2009 March 2012. Results Laryngeal tumors were involving glottis (13 cases) supraglottis (10 cases). They classified N0 in 16 cases, four N+ three cases. The median...
Abstract BACKGROUND This prospective multicenter study evaluated the prognostic value of circulating tumor cells (CTCs) in relapsing nonoperable or metastatic head and neck squamous cell carcinoma (rHNSCC) treated by chemotherapy cetuximab. METHODS In 65 patients suitable for analyses, peripheral blood was taken at day 0 (D0) D7, D21 treatment CTC detection CellSearch®, EPISPOT, flow cytometry (FCM). Progression-free survival (PFS) assessed with Kaplan–Meier method compared log-rank test (P...
Objectives: Parathyroid hormone (PTH) is a risk marker for hypoparathyroidism (hypoPTH). This study aimed to determine the predictive values of early PTH assays carried out at moment skin closure (PTH SC), establish treatment algorithm, identifying two threshold values. We assessed reproducibility this approach with different immunoassay kits (hypoPTH) after total thyroidectomy, but its practical application not consensual. Study Design: conducted prospective descriptive study, including all...
Gemcitabine (2',2'-difluorodeoxycytidine) is a major antimetabolite cytotoxic drug with wide spectrum of activity against solid tumors. Hepatic elimination gemcitabine depends on catabolic pathway through deamination step driven by the enzyme cytidine deaminase (CDA). Severe hematologic toxicity to was reported in patients harboring genetic polymorphisms CDA gene. High-resolution melting (HRM) analysis polymerase chain reaction amplicon emerges today as powerful technique for both genotyping...
Background: Robot-assisted endoscopic transaxillary thyroidectomy is an emerging surgical technique that needs to be evaluated in European patients. We evaluate the feasibility and preliminary results of our experience this a cohort patients from within single university hospital (Nîmes, France). Methods: performed retrospective review first 23 patients, treated consecutively between September 2010 June 2012. Results: Nine underwent total 14 lobectomies. All procedures were completed...
Neoadjuvant TPF (docetaxel, cisplatin, 5-fluorouracil), followed by radiotherapy or chemoradiotherapy with weekly carboplatin, increases overall survival and organ preservation. We assessed whether could be used in routine practice potentiated cisplatin cetuximab was feasible increase survival. retrospectively reviewed 157 patients advanced head neck squamous cell carcinoma treated four French institutions between May 2005 March 2009. After induction, operable had undergone surgery were...
Abstract Background Robot‐assisted endoscopic transaxillary thyroidectomy is an emerging surgical technique. Despite promising results it presents some limitations and remains controversial in terms of usefulness validity. We developed alternative robotic technique using a gasless infraclavicular approach. Methods tested this approach cadaveric dissection, then we performed the on series 21 patients from October 2009 to July 2010. Results Sixteen underwent total 5 lobectomies. Mean operative...