A5010483445- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Blood transfusion and management
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Renal and Vascular Pathologies
- Hemoglobin structure and function
- Thyroid Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Glioma Diagnosis and Treatment
- Circadian rhythm and melatonin
- Head and Neck Anomalies
- Brain Metastases and Treatment
- Thermal Regulation in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Thyroid and Parathyroid Surgery
- Kidney Stones and Urolithiasis Treatments
- Acute Kidney Injury Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Telemedicine and Telehealth Implementation
- Bariatric Surgery and Outcomes
- Neurological Complications and Syndromes
University of Oxford
2015-2025
Oxford University Hospitals NHS Trust
2019-2024
National Health Service
2023
Peter MacCallum Cancer Centre
2022
Wycombe General Hospital
2022
Nuffield Orthopaedic Centre
2021
Churchill Hospital
2020
Oxford Centre for Diabetes, Endocrinology and Metabolism
2020
University College Hospital
2016
University College London
2016
Abstract Introduction Normothermic machine perfusion of the kidney (NMP-K) is a technique for ex-situ preservation, assessment, and treatment kidneys prior to transplantation. We have previously reported phase 1 trial (NKP1) showing that up 24 hours NMP-K appears be safe, feasible, NRF-2 modulation may benefit. Nitric oxide (NO) potent inducer NRF2 has been shown halve rate acute injury after cardiopulmonary bypass. therefore sought develop test paradigm NO during NMP-K. Methods Six pairs...
The volume of oxygen drawn from systemic capillaries down a partial pressure gradient is determined by the content red blood cells (RBCs) and their oxygen-unloading kinetics, although latter assumed to be rapid and, therefore, not meaningful factor. Under this paradigm, transfer tissues perfusion-limited. Consequently, clinical treatments optimize delivery aim at improving flow arterial content, rather than RBC handling. Although oxygen-carrying capacity increased with transfusion, studies...
<title>Abstract</title> Kidney transplantation is the preferred treatment for end-stage renal disease and limited by donor organ availability. Normothermic Machine Perfusion (NMP) might facilitate safe of marginal organs. Previous clinical implementations have been to short perfusions. NKP1 was a single centre, phase 1, 36-patient, three-stage cohort study investigating safety feasibility up 24 hours NMP prior transplantation. We observed 30-day graft survival 100%, with comparable outcomes...
Static cold storage (SCS) is the standard method for pancreas preservation prior to transplantation; however, it does not permit organ assessment. Normothermic reperfusion (NR) utilized clinically other organs assess viability. Our aim was develop NR using normothermic machine perfusion technique simulate at time of transplantation, enabling evaluation oxygenated hypothermic (HMPO2) as a newer strategy optimize preservation. 13 porcine pancreases procured after circulatory death were divided...
In kidney transplantation, the relative contribution of various donor, procedure and recipient-related factors on clinical outcomes is unknown. Previous paired studies have largely focused examining predicting early outcomes, where effect donor thought to be most important. Here, we sought examine relationship between long-term in a UK-wide analysis.UK Transplant Registry data covering 24,090 transplants performed 2001-2018, both kidneys from each were transplanted, analysed. Case-control...
Ischaemia-reperfusion injury (IRI) is an inevitable process in transplantation and results inflammation immune system activation. Alpha-1 antitrypsin (AAT) has anti-inflammatory properties. Normothermic machine perfusion (NMP) can be used to deliver therapies may help assessing the effects of IRI immunity. This study investigated AAT on pig kidneys when administered during preservation, followed by normothermic reperfusion (NR) with autologous whole blood, as a surrogate for transplant. Two...
Advances in organ preservation, reconditioning and assessment have been driven by the increasing necessity to utilise organs from extended criteria donors, particularly donors after circulatory death. Research efforts this area aided translation of machine perfusion technology into clinical practice. Pigs are anatomically physiologically similar humans an excellent model. However, conducting large animal experimental research is challenging typically limited ethical economic constraints....
Journal Article Variation in treatment of intrahepatic cholangiocarcinoma: a nationwide multicentre study Get access Jane McClements, McClements Department HPB Surgery, Nottingham University Hospitals NHS Trust, Nottingham, UK Search for other works by this author on: Oxford Academic Google Scholar Juan W Valle, Valle Oncology, Christie Foundation Manchester, https://orcid.org/0000-0002-1999-0863 Lauren Blackburn, Blackburn Adam Brooks, Brooks Andreas Prachalias, Prachalias Surgery and...
Sleep and circadian rhythm disruption is frequently associated with neurodegenerative disease, yet it unclear how the specific pathology in these disorders leads to abnormal rest/activity profiles. To investigate whether pathological features of lysosomal storage (LSDs) influence core molecular clock or behavioural abnormalities reported some patients, we examined mouse models Niemann-Pick Type-C (Npc1 mutant, Npc1nih) Sandhoff (Hexb knockout, Hexb−/−) disease using wheel-running activity...
Ureteroscopy is a commonly performed endourological procedure. Raised pelvicalyceal pressure (PCP) an unavoidable consequence of this procedure, as degree distension required to visualize the ureter and collecting system. This raised achieved primarily by saline irrigation through working channel ureteroscope. The adverse effects such pressures are known include pyelovenous reflux, which movement substances from renal pelvis into vascular compartment kidney includes contrast agents pathogens...
INTRODUCTION Transplantation as a field has been defining development of 20th century medicine. The transformation from experimental procedure to routine, lifesaving, gold-standard treatment for end-stage organ failure rapid and unprecedented. purpose this article is briefly describe the progress that made, great deal work which remains be done, transplantation moved into 21st century. Our overarching thesis faced three major eras challenge. first was predominantly technical, during...
Abstract Background The storage lesion is a multifactorial degradation effect seen in units of banked blood, and results an increase the time-constant oxygen-unloading from red cells (tau). We have previously shown relevance this observational data recent clinical trial prolonged normothermic kidney perfusion as preservation technique ahead transplantation. sought direct confirmatory evidence for diffusion-limited oxygen release by stored (RBCs) during precisely controlled experimental...
Background. Whole pancreas transplantation (Tx) is a successful treatment for type 1 diabetes resulting in independence from antidiabetic therapies. Transplant-related factors contributing to pancreatic islet failure are largely unknown; both recurring insulitis and pancreatitis have been implicated. The aim was determine if cellular changes islets exocrine tissue evident early Tx, which could contribute eventual graft using well-preserved of grafts explanted normoglycemic recipients....
We describe a case of 67-year-old man with known chronic obstructive pulmonary disease, type 2 diabetes mellitus, hypertension, osteoarthritis, previous history excess alcohol intake, and oesophagectomy 3 years earlier for T3N0 adenocarcinoma, referred by his general practitioner confusion, weight loss several recent falls. CT the chest, abdomen pelvis revealed right middle-lobe embolism, while head communicating hydrocephalus. Lumbar puncture was performed, empirical treatment tuberculous...
The 2016 American Thyroid Association (ATA) guidelines proposed thyroid lobectomy for low-risk differentiated cancer (DTC); however, this approach is yet to be widely adopted. aim of the study was review our practice over three years following publication these identifying patients who underwent lobectomy-only DTC in two regional units same multidisciplinary team (MDT).A retrospective were operated between January and December 2018 carried out.In total, 288 undergoing surgery included....
Pancreatic transplantation is usually performed simultaneously with renal in the setting of end-stage nephropathy and type 1 diabetes. Surgical methods for dealing exocrine secretions include bladder drainage, direct duodenojejunostomy Roux-en-Y (ReY) enteric drainage. may confer an advantage over because it distances content from transplant duodenal anastomosis. We examined effect drainage method on outcomes.Data were obtained UK registry 2172 consecutive pancreatic transplants. Early graft...
Introduction Currently there is an urgent need to translate interventions that may be beneficial marginal donor kidneys prior transplant, improve their quality from bench bedside. This project investigated the effects of CC-4066, a potent dual inhibitor cyclophilin proteins A and D, treatment during static cold storage (SCS) in porcine model renal ischemia-reperfusion injury (IRI) using Normothermic Reperfusion (NR). Materials methods Porcine autologous blood were retrieved pairs local...
ABSTRACT A central dogma in physiology is that oxygen release at tissues not diffusion-limited because gas exchange capillaries rapid. This assertion has influenced clinical care, which focuses on optimising delivery through improving blood flow and content, rather than unloading from red cells (RBCs). Since storage of causes profound changes slow RBCs, transfusions could compromise tissue respiration. We investigated this transplant human kidneys normothermically perfused with stored blood....