A5017244221- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Pneumonia and Respiratory Infections
- Plant Pathogenic Bacteria Studies
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Immune Response and Inflammation
- interferon and immune responses
- Infectious Diseases and Tuberculosis
- Cystic Fibrosis Research Advances
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- Orthopedic Infections and Treatments
- Oral microbiology and periodontitis research
- Renal Transplantation Outcomes and Treatments
- Antimicrobial Resistance in Staphylococcus
- Immune responses and vaccinations
- Infective Endocarditis Diagnosis and Management
Hospital Israelita Albert Einstein
2018-2023
Instituto de Saúde
2022
Albert Einstein College of Medicine
2022
Universidade Estadual de Maringá
2016-2019
Universidade de São Paulo
2017-2018
Pseudomonas aeruginosa is a ubiquitous microorganism and an important opportunistic pathogen responsible for broad spectrum of infections mainly in immunosuppressed critically ill patients. Molecular investigations traditionally rely on pulsed field gel electrophoresis (PFGE) multilocus sequence typing (MLST). In this work we propose core genome (cgMLST) scheme P. aeruginosa, methodology that combines traditional MLST principles with whole sequencing data. All publicly available complete...
Background Healthcare-associated infections by carbapenem-resistant Klebsiella pneumoniae are difficult to control. Virulence and antibiotic resistance genes contribute infection, but the mechanisms associated with transition from colonization infection remain unclear. Objective We investigated carriage K. isolates carrying carbapenemase–encoding gene bla KPC (KpKPC). Methods KpKPC detected within a 10-year period in single tertiary-care hospital were characterized pulsed-field gel...
Klebsiella pneumoniae is considered an opportunistic pathogen frequently involved with healthcare-associated infections. The genome of K. versatile, harbors diverse virulence factors and easily acquires exchanges resistance plasmids, facilitating the emergence new threatening clones. In last years, ST16 has been described as emergent, clinically relevant strain, increasingly associated outbreaks, carrying (such ICEKp, iuc, rmpADC/2) a diversity genes. However, far-reaching phylogenetic study...
Klebsiella pneumoniae carbapenemase (KPC) actively hydrolyzes carbapenems, antibiotics often used a last-line treatment for multidrug-resistant bacteria. KPC clinical relevance resides in its widespread dissemination. In this work, we report the genomic context of coding genes blaKPC-2, blaKPC-3 and blaKPC-30 Klebsiellapneumoniae isolates from Brazil. Plasmids harboring were identified. Fifteen additional carbapenem-resistant K. selected same tertiary hospital, collected over period 8 years....
Purpose. The effect of a combination polymyxin B (PMB) and vancomycin (VAN) was assessed against six Acinetobacter baumannii clinical isolates belonging to different clusters (three PMB-susceptible three PMB-resistant). Methodology. synergistic the PMB–VAN determined with checkerboard, time-kill, disk-diffusion M.I.C.Evaluator assays. PMB-resistance investigated mcr-1 gene amplification mutant frequency assay. Results. In checkerboard assay, all PMB-resistant showed effect. time-kill assay...
Bacterial resistance is a severe threat to global public health. Exposure sub-lethal concentrations has been considered major driver of mutagenesis leading antibiotic in clinical settings. Ciprofloxacin broadly used treat infections caused by Pseudomonas aeruginosa, whereas increased induced ciprofloxacin reported for the reference strain, PAO1, vitro. In this study we report another PA14-UCBPP, and lower isolates when compared strain. This unexpected result may be associated with missense...
Pseudomonas aeruginosa is an important opportunistic pathogen in hospitals, responsible for various infections that are difficult to treat due intrinsic and acquired antibiotic resistance. Here, 20 epidemiologically unrelated strains isolated from patients a general hospital over time period of two decades were analyzed using whole genome sequencing. The genomes compared order assess the presence predominant clone or sequence type (ST). No clonal structure was identified, but core...
Raoultella planticola harboring genes that confer resistance to antimicrobials, such as carbapenems, have been associated with severe infections in immunocompromised patients. In this study, we reported the first whole genome sequence of a Brazilian isolate R. and genomic context antibiotic markers. By whole-genome sequencing (WGS) carbapenem-resistant isolate, RpHUM1, found 23 resistance-encoding belonging 9 classes antibiotics (aminoglycosides, β-lactams, fluoroquinolones, fosfomycin,...