A5101879483- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Advanced Polymer Synthesis and Characterization
- Metal-Organic Frameworks: Synthesis and Applications
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticles: synthesis and applications
- biodegradable polymer synthesis and properties
- Spectroscopy and Quantum Chemical Studies
- Breast Cancer Treatment Studies
- AI in cancer detection
- Lanthanide and Transition Metal Complexes
- Advanced Drug Delivery Systems
- Neonatal Respiratory Health Research
- Copper-based nanomaterials and applications
- Polymer Surface Interaction Studies
- Curcumin's Biomedical Applications
- 3D Shape Modeling and Analysis
- MXene and MAX Phase Materials
- Lung Cancer Diagnosis and Treatment
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Plant Gene Expression Analysis
- MicroRNA in disease regulation
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2025
Fudan University
2025
Sun Yat-sen University
2025
Jiangxi University of Science and Technology
2021-2025
Cancer Hospital of Chinese Academy of Medical Sciences
2025
Sichuan University
2024
First Affiliated Hospital of Zhengzhou University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Chongqing University
2015-2023
A novel graphene oxide nanoparticle (GON)-based drug delivery system containing GONs as carriers of anticancer drugs and chitosan/dimethylmaleic anhydride-modified chitosan (CS/CS-DMMA) surface charge-reversible shells is fabricated via the classic self-assembly deprotonated carboxyl protonated amine CS backbone by electrostatic interaction, CS-DMMA serves outmost layer. In this GON-based system, GON cores desired might adsorb doxorubicin hydrochloride (DOX) π-π stacking interaction between...
Poly(<sc>l</sc>-lactide) (PLLA) is a promising bone repair material owing to its good biocompatibility and natural degradability, but lack of bioactivity insufficient mechanical property restrict further application.
With the existence of amino groups, chitosan (CS) possesses positive charge, so it can self-assemble with tripolyphotspate (TPP) possessing negative charge via ionic gelation. We here synthesized CS/TPP nanoparticles, and then characterized infrared spectra (IR) scanning electron microscope (SEM) transmission microscopy (TEM) used bovine serum albumin (BSA) as a model drug to investigate sustained-release properties nanoparticles. Infrared spectrum nanoparticles indicated that CS was...
A hydrogen peroxide (H2O2)/glutathione (GSH) dual-sensitive nanoplatform holds great promise to alleviate the side effects of chemo drugs and improve their therapeutic efficacy against cancer. The site-specific release with a low premature still remains challenge in field chemotherapy. In present work, novel multifunctional drug delivery system (DDS) based on polymethylacrylic acid core cross-linked structure disulfide bond (PMAABACy), metal-organic framework (MOF) interlayer biologically...
Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA prepared by selective laser sintering to accelerate degradation. The reason that GO with a large number of oxygen-containing functional groups attracted water molecules transported them through interface microchannels formed between lamellar matrix....
The rise of antibiotic resistance poses a significant and ongoing challenge to public health, with pathogenic bacteria remaining persistent threat. Traditional culture methods, while considered the gold standard for bacterial detection viability assessment, are time-consuming labor-intensive. To address this limitation, we developed novel point-of-care (POC) method leveraging citrate- alkyne-modified nanorods (AuNRs) synthesized click chemistry properties. These AuNRs exhibit superior...
Iron oxide (Fe-O) has anti-tumor properties, due to its ability of catalyzing hydrogen peroxide (H2O2) tumor cells generate reactive oxygen species (ROS) and then cause ferroptosis. Its performance is restricted insufficient H2O2 in cells. A nanomedicine, Au nanoparticles (NPs) grown on Fe-O, was integrated into poly-l-lactide (PLLA) scaffolds. Results indicated that NPs could consume glucose produce H2O2, which supplemented reaction substrate. PLLA/Au@Fe-O scaffold showed enhanced...
<title>Abstract</title> <bold>Objective:</bold> To establish a quality evaluation index system for the diagnosis and treatment of lung cancer. <bold>Method:</bold> The Donabedian health assessment model Delphi method were used to construct an indicator system, Analytic Hierarchy Process was determine weights each level indicators. <bold>Result:</bold> final constructed includes 3 primary indicators: structure, process outcome, 15 secondary indicators, 55 tertiary Structural indicators...
Poly[3-azido-2-(2-bromo-2-methylpropanoyloxy)propyl methacrylate] (PAzBrMA) was synthesized as the macroinitiator and anchor for a functional polymer brush coating on polyurethane (PU) films. Ring-opening reaction of epoxide group poly(glycidyl methacrylate) with sodium azide produced hydroxyl groups. The groups were substituted 2-bromoisobutyryl bromide to introduce alkyl halide initiator. For anchoring, ultraviolet irradiation applied convert PAzBrMA physically coated PU surface into...
A glutathione-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] (PMAABACy-co-PEGMA) nanogel with tunable stability has been fabricated through covalent and metal double-cross-linking strategies in response to the differential change of GSH concentration between inside outside tumor cells. Herein, size-controlled PMAA-co-PEGMA that possessed unique core–shell structure was first obtained via adjusting length PEGMA. Furthermore, N,N-bis(acryloyl)cystamine...
Abstract Aim Pathologists are currently supposed to be aware of both domestic and international guidelines for breast cancer diagnosis, but it is unclear how successfully these have been integrated into routine clinical practice in China. Thus, this national proficiency testing (PT) scheme pathology was set up conduct a baseline assessment the diagnostic capability pathologists Methods This PT plan designed implemented according “Conformity assessment—General requirements testing”...
Anthropometric data form the cornerstone of garment pattern-making. This article introduces an artificial intelligence-driven approach, employing a back-propagation neural network (BP-ANN), to predict anthropometric essential for crafting patterns women's upper tops. The model adeptly processes minimal critical from bodies, yielding projected dimensions that are arduous manually measure yet crucial tailoring body-fitting Utilising three-dimensional body scanner accurate collection 196 women...
Smart poly(methacrylic acid-co-N,N-bis(acryloyl)cystamine)/DOX/MnO2-2/polyethylene glycol theranostic nanohybrids (PMAABACy/DOX/MnO2-2/PEG TNs) were rationally fabricated using in situ generation of amorphous MnO2 by taking advantage the spatial confinement effect PMAABACy nanohydrogels, and its PEGylation was accomplished through Mn–N coordinate bonding. The PMAABACy/DOX/MnO2-2/PEG TNs synthesized chelation between Mn2+ ions carboxyl groups PMAA chains, which served as a gatekeeper to...