A5023305270- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- Antifungal resistance and susceptibility
- Cervical Cancer and HPV Research
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Stress Responses and Cortisol
- Cytomegalovirus and herpesvirus research
- Health, Environment, Cognitive Aging
- Viral-associated cancers and disorders
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Colorectal and Anal Carcinomas
Milwaukee Health Department
2023
Medical College of Wisconsin
2016-2021
University of California, San Francisco
2009-2015
San Francisco General Hospital
2014
Background: There is intense interest in the role of programmed death 1 (PD-1) causing persistent T-cell dysfunction HIV infection. However, impact infection and antiretroviral treatment (ART) on expression PD-1 T cells still poorly defined. Methods: was measured longitudinally a cohort recently HIV-infected individuals (n = 121) who started ART early (<6 months after infection) vs. later (≥2 years infection). also cross-sectionally diverse chronically adults 206). Results: levels were high...
The association between the host immune environment and size of HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by lack a well-accepted assay for quantifying therapy. We examined multiple measurements T cell activation (as defined markers including CD38, HLA-DR, CCR5 PD-1) in 30 antiretroviral-treated HIV-infected adults. found consistent frequency CD4+ CD8+ cells expressing HLA-DR resting containing DNA. This study highlights need to...
Sexual minority men are at increased risk for anal squamous cell carcinoma. Our objective was to compare screening engagement among individuals randomized self-collect an canal specimen home or attend a clinic appointment. Specimen adequacy then assessed human papillomavirus (HPV) DNA genotyping. A trial recruited cisgendered sexual and transgender people in the community assigned them use home-based self-collection swabbing kit clinic-based swabbing. Swabs were sent HPV The proportions of...
Objective: To determine the relationship of HIV infection, demographic, and cardiovascular disease (CVD) risk factors with mortality in recent highly active antiretroviral therapy era. Methods: Vital status was ascertained from 2004 to 2007 922 infected 280 controls Study Fat Redistribution Metabolic Change infection; 469 were included analysis comparing similar age controls. Multivariable exponential survival regression (adjusting for demographic CVD factors) estimated hazard ratios (HRs)...
Objective: The eradication of HIV necessitates elimination the latent reservoir. Identifying host determinants governing latency and reservoir size in setting antiretroviral therapy (ART) is an important step developing strategies to cure infection. We sought determine impact cell-intrinsic immunity on Design: investigated relevance a comprehensive panel established anti-HIV-1 restriction factors multiple virologic immunologic measures viral persistence HIV-1-infected, ART-suppressed...
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated HIV reservoir in 18 heterozygotes and 54 wild-type individuals during suppressive antiretroviral therapy. Cell-associated RNA levels (P = .035), DNA transcriptional ratios .013), frequency detectable 2–long terminal repeat circular .013) were significantly lower CD4+ T cells from heterozygotes. was...
Abstract Background Circadian transcription factors that regulate cell-autonomous circadian clocks can also increase human immunodeficiency virus (HIV) in vitro. We aimed to determine whether variation HIV exists people with (PWH) on antiretroviral therapy (ART). Methods performed a prospective observational study of male PWH ART, sampling blood every 4 hours for 24 hours. Using quantitative polymerase chain reaction, we quantified expression circadian-associated genes, deoxyribonucleic acid...
In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril antiretroviral therapy (ART) reverses fibrosis gut tissue, and this leads reduction RNA DNA levels.Thirty HIV-infected individuals on ART were randomized at 20mg daily or matching placebo for 24 weeks. All participants underwent rectal biopsies prior starting drug 22 weeks, there regular...