A5101887158- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Research and Treatments
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Long-Term Effects of COVID-19
- Cancer-related gene regulation
- Streptococcal Infections and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related Molecular Pathways
- COVID-19 diagnosis using AI
- Extracellular vesicles in disease
- Hypertrophic osteoarthropathy and related conditions
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Dermatological and Skeletal Disorders
Chinese University of Hong Kong, Shenzhen
2025
Hebei Yiling Hospital
2025
Zhongshan Hospital
2011-2024
Fudan University
2011-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2023
Sun Yat-sen University
2017-2023
Hospital for Sick Children
2022
Guangzhou Medical University
2017
Abstract Background: Baicalin is considered to be able alleviate the progression of ulcerative colitis (UC), but underlying molecular mechanism needs further elucidated. Methods: TNF-α-induced human normal colorectal mucosa cells (FHC) were used mimic UC models in vitro , and trinitrobenzene sulfonic acid (TNBS)-injected rats construct vivo . Cell proliferation apoptosis determined by CCK8 assay, EdU assay flow cytometry. Inflammation factors examined ELISA, ferroptosis-related markers...
Radiation-induced pulmonary fibrosis (RIPF) is a life-threatening complication of thoracic radiotherapy, which contributes to continued deterioration in function. Sphingosine-1 phosphate receptor 3 (S1PR3) has been identified as crucial molecule fibrosis. Accumulating evidence indicated that the inhibition S1PRs ameliorates fibrogenesis. Thus, this study aims explore whether S1PR3 participates RIPF and elucidates molecular mechanisms underlying S1PR3-modulated epithelial-mesenchymal...
Abiotrophia (ABI) and Granulicatella (GRA) are rare causative pathogens in infective endocarditis (IE). This study aims to describe the epidemiology, clinical characteristics, outcome of ABI/GRA-IE. The main features ABI/GRA-IE were compared with Viridans group streptococci (VGS) IE.
Acute lung injury or acute respiratory distress syndrome (ALI/ARDS) is a devastating clinical with high incidence and mortality rates. IRE1α-XBP1 pathway one of the three major signaling axes endoplasmic reticulum stress that involved in inflammation, metabolism, immunity. The role potential mechanisms axis ALI/ARDS has not well understood. ALI murine model was established by intratracheal administration lipopolysaccharide (LPS). Hematoxylin eosin (H&E) staining analysis bronchoalveolar...
Abstract Background Adult patients diagnosed as COVID-19 in Shanghai were accepted Public Health Clinical Center. We found around 4.91% of cases showed non-pneumonia on CT imaging when they confirmed. Understanding the characteristics is great significance to guide clinical treatment and improve prevention control measures. Methods All dataset demography, epidemiology, manifestation, laboratory test, diagnosis, classification, condition change, outcome obtained by retrospective...
<p>charateritics of 84 HNSCC patients</p>
Objective To investigate the relationship between miR-411 and breast cancer, expression of its effects mechanism research on proliferation metastasis in cancer. Methods Real-time polymerase chain reaction (RT-PCR) was used to detect cancer cells tissues. Methyl thiazolyl tetrazolium (MTT), clone formation assay Transwell were effect proliferation, migration invasion cells. The growth factor receptor-bound protein 2 (GRB2) detected by RT-PCR Western blot. direct target GRB2 dual...
Abstract Irx1 and Irx2 ( Irx1/2 ) are two closely linked widely expressed members of the conserved Iroquois homeobox family transcription factors. Despite mounting evidence suggesting importance homologs these genes in many aspects vertebrate development function, role mammals has remained largely unknown. Here, we used mice carrying our newly generated flox del mutant alleles to perform a stepwise genetic ablation levels. Our analysis revealed reduced postnatal growth viability KO with...