We directly examined the role of Ca v 1.3 (α 1D ) 2+ channel in sinoatrial (SA) node by using channel-deficient mice. A previous report has shown that null mutant (Ca −/− mice have sinus bradycardia with a prolonged PR interval. In present study, we show spontaneous action potentials recorded from SA nodes significant decrease beating frequency and rate diastolic depolarization compared their heterozygous +/− or wild-type (WT, +/+ littermates, suggesting deficit is intrinsic to node....

An intermolecular radical-radical cross-coupling reaction of secondary and tertiary amines with aryl ketones aldehydes has been developed using visible light photoredox catalysis. This provides an efficient straightforward approach to some useful 1,2-amino alcohols in moderate good yields under mild conditions.

This paper discloses the first example of photocatalytic direct decarboxylative hydroxylation carboxylic acids. It enables conversion a variety readily available acids to alcohols in moderate high yields. unprecedented protocol is accomplished under extremely mild reaction conditions using molecular oxygen (O2) as green oxidant and visible light driving force.

The coronavirus disease 2019 (COVID-19) pandemic has caused a tremendous global impact both socially and economically. mechanisms behind the disparity in severity, vaccine coverage, variant replacement patterns across European countries are unclear. In this work, we aim to reveal possible reasons via data visualization model fitting. We developed with vaccination component simulate mortality waves these countries. Deaths averted by campaign were estimated. Finally, discuss potential...

Abstract With the outbreak of COVID-19 in Wuhan, aggressive countermeasures have been taken, including implementation unprecedented lockdown city, which will necessarily cause huge economic losses for city Wuhan. In this paper, we attempt to uncover interactions between epidemic prevention and control measures economic-social development by estimating health loss meso-economic from a human-oriented perspective. We implemented compartmental model transmission dynamics burden assessment...

To model estimated deaths averted by COVID-19 vaccines, we used state-of-the-art mathematical modeling, likelihood-based inference, and reported death vaccination data. We that >1.5 million were in 12 countries. Our can help assess effectiveness of the program, which is crucial for curbing pandemic.

Background Recent evidences suggested that IL-37 may participate in the pathophysiology of community-acquired pneumonia (CAP). Nevertheless, its exact biological role was unknown. The objective this study to determine associations serum with severity and prognosis CAP patients based on a retrospective cohort study. Methods whole 120 healthy subjects 240 were summoned. Peripheral blood collected detected using ELISA. Results Serum obviously decreased admission. In addition, gradually parallel...

COVID-19 pandemic remains serious around the world and causes huge deaths economic losses. To investigate effect of vaccination isolation delays on transmission COVID-19, we propose a mathematical model with delays. The basic reproduction number is computed, global dynamics are proved. When R0<1, disease-free equilibrium globally asymptotically stable. unique endemic stable if R0>1. Based public information, parameter values estimated, sensitivity analysis carried out by partial rank...

Competitive exclusion is frequently observed in the chemostat when multiple species compete exploitatively for a single growth-limiting nutrient. However, rigorous mathematical proof competitive very limited, especially delayed models with differential removal rates. In this paper, by employing method of Liapunov functionals and placing two assumptions on response functions, we prove that holds under generic condition rates discrete (also finitely distributed) delays. For large variety...

Background: By February 2021, the overall impact of coronavirus disease 2019 (COVID-19) in South and Southeast Asia was relatively mild. Surprisingly, early April second wave significantly impacted population garnered widespread international attention. Methods: This study focused on nine countries with highest cumulative deaths from as August 17, 2021. We look at COVID-19 transmission dynamics using reported death data, which fits a mathematical model time-varying rate. Results: estimated...

By February 2021, the overall impact of COVID-19 pandemic in India had been relatively mild terms total reported cases and deaths. Surprisingly, second wave early April becomes devastating attracts worldwide attention. Multiple factors (e.g., Delta variants with increased transmissibility) could have driven rapid growth epidemic led to a large number deaths within short period. We aim reconstruct transmission rate, estimate infection fatality rate forecast size. download mortality data...

In this paper, we incorporate an extra logistic growth term for uninfected CD4+ T-cells into HIV-1 infection model with both intracellular delay and immune response which was studied by Pawelek et al. in [26]. First, proved that if the basic reproduction number R0 < 1, then infection-free steady state is globally asymptotically stable. Second, when > system uniformly persistent, suggesting clearance or uniform persistence of virus completely determined R0. Furthermore, given two delays are...

Functional interactions between ligand-gated, voltage-, and Ca 2+ -activated ion channels are essential to the properties of excitable cells thus working nervous system. The outer hair in mammalian cochlea receive efferent inputs from brain stem through cholinergic nerve fibers that form synapses at their base. acetylcholine released these activates fast inhibitory postsynaptic currents mediated, some extent, by small-conductance K + (SK) had not been cloned. Here we report cloning,...

In this paper, a multistage susceptible‐infectious‐recovered model with distributed delays and nonlinear incidence rate is investigated, which extends the considered by Guo et al . [H. Guo, M. Y. Li Z. Shuai, Global dynamics of general class models for infectious diseases, SIAM J. Appl. Math., 72 (2012), 261–279] Under some appropriate realistic conditions, global completely determined basic reproduction number R 0 If ≤1, then infection‐free equilibrium globally asymptotically stable disease...

We assessed the functional determinants of properties L-type Ca(2+) currents in hair cells by co-expressing pore-forming Ca(V)1.3alpha(1) subunit with auxiliary subunits beta(1A) and/or alpha(2delta). Because channels are poised to interact synaptic proteins, we also co-expressed syntaxin, vesicle-associated membrane protein (VAMP), and synaptosome associated 25 kDa (SNAP25). Expression human embryonic kidney (HEK 293) produced a dihydropyridine (DHP)-sensitive current (peak density -2.0 +/-...

In this paper, a new theorem which is proved in Lu et al (2005 Discrete Contin. Dyn. Syst. 8 701–19) applied to some nonlinear reaction–diffusion equation with normal external forces (see definition 3.1.), translation bounded but not compact. We obtain the existence of uniform attractor without any restriction on growing order term. The attracts all subsets norm . Then structure obtained by constructing skew-product flow extended phase space weak topology.

Wuhan shutdown was implemented on January 23 and the first level response to public health emergencies (FLRPHE) launched over country, then China got outbreak of COVID-19 under control. A mathematical model is established study transmission in Wuhan. This research investigates spread assesses effectiveness control measures including city travel ban FLRPHE. Based dynamical analysis data fitting, estimated effects FLRPHE are investigated. According assumptions, basic reproduction number for...