A5035038863- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Mosquito-borne diseases and control
- Tryptophan and brain disorders
- Cognitive Functions and Memory
- Bipolar Disorder and Treatment
- Cytomegalovirus and herpesvirus research
- Cognitive Abilities and Testing
- Educational and Psychological Assessments
- Forensic Toxicology and Drug Analysis
- Attention Deficit Hyperactivity Disorder
- Ovarian function and disorders
- Traumatic Brain Injury Research
- Developmental and Educational Neuropsychology
- Language Development and Disorders
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Cerebral Palsy and Movement Disorders
- Pain Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
University of California, San Diego
2015-2024
Neurobehavioral Research (United States)
2010-2024
Universitat de Barcelona
2021
San Diego State University
2009-2020
Santa Clara Valley Medical Center
2020
University of San Diego
2017
Marymount University
2016
Pancreatic Cancer Action Network
2016
Princip (Czechia)
2016
University of California System
2014
Abstract Demographic factors impact neuropsychological test performances and accounting for them may help to better elucidate current brain functioning. The NIH Toolbox Cognition Battery (NIHTB-CB) is a novel tool, yet the original norms developed battery did not adequately account important demographic/cultural known performances. We fully adjusting all demographic variables within each language group (English Spanish) separately. study describes standards individuals tested in English....
A randomized, double-blinded, placebo controlled crossover study was conducted in 16 patients with painful diabetic peripheral neuropathy to assess the short-term efficacy and tolerability of inhaled cannabis. In a design, each participant exposed 4 single dosing sessions or low (1% tetrahydrocannabinol [THC]), medium (4% THC), high (7% THC) doses Baseline spontaneous pain, evoked cognitive testing were performed. Subjects then administered aerosolized cannabis pain intensity subjective...
Background. Antiretroviral (ARV) medications differentially penetrate across the blood-brain barrier into central nervous system (CNS) tissues, potentially influencing their effectiveness in treating brain infection. Methods. This randomized controlled clinical trial (RCT) called for 120 participants at 5 study sites to be 1:1 CNS-targeted (CNS-T) or non–CNS-T ART. Entry factors such as ARV experience were balanced arms using an adaptive randomization approach. The primary outcome, change...
HIV-associated neurocognitive disorders (HANDs) persist even with virologic suppression on combination antiretroviral therapy (cART), and the underlying pathophysiological mechanisms are not well understood. We performed structural magnetic resonance imaging MR spectroscopy (MRS) in HIV+ individuals without major comorbidities. Study participants were classified as neurocognitively unimpaired (NU), asymptomatic (ANI), mild disorder (MND), or HIVassociated dementia (HAD). Using MRI, we...
Expanding cannabis medicalization and legalization increases the urgency to understand factors associated with acute driving impairment.To determine, in a large sample of regular users, magnitude time course impairment produced by smoked different Δ9-tetrahydrocannabinol (THC) content, effects use history, concordance between perceived observed performance.This double-blind, placebo-controlled parallel randomized clinical trial took place from February 2017 June 2019 at Center for Medicinal...
We evaluated the accuracy and precision of continuous overnight oxygen saturation (SpO
The apolipoprotein E (APOE) ε4 allele enhances cerebral accumulation of β-amyloid (Aβ) and is a major risk factor for sporadic Alzheimer's disease. We hypothesized that HIV-associated neurocognitive disorders (HAND) would be associated with the APOE genotype Aβ deposition.Clinicopathological study HIV-infected adults from four prospective cohorts in US National NeuroAIDS Tissue Consortium.We used multivariable logistic regressions to model outcomes [Aβ plaques (immunohistochemistry) HAND...
Objective: HIV-associated neurocognitive disorders (HANDs) remain prevalent in patients who receive HAART and may be associated with cumulative exposure to antiretroviral medications other factors. We proposed that chronic toxic effects of drugs could contribute cerebral small vessel disease (CSVD), which might one the key underpinnings HAND. Design: Clinicopathological cross-sectional study HIV-infected adults California NeuroAIDS Tissue Network. Methods: employed multivariable logistic...
The Veterans Aging Cohort Study (VACS) Index is predictive of mortality and combines age, traditional HIV biomarkers (HIV-1 plasma RNA current CD4 count), non-HIV (indicators renal liver function, anemia, hepatitis C coinfection). We examined the association between VACS HIV-associated neurocognitive impairment (NCI).Participants included 601 HIV-infected adults enrolled in cohort studies at University California, San Diego, Neurobehavioral Research Program (ages: 18-76 years; 88% male; 63%...
The potential role of gender in the occurrence HIV-related neurocognitive impairment (NCI) and associations with markers immune activity has not been previously examined. In this study 149 antiretroviral-naïve seropositive subjects Nigeria (SP, 92 women 57 men) 58 seronegative (SN, 38 20 were administered neuropsychological testing that assessed 7 ability domains. From test scores was calculated a global deficit score (GDS), measure overall NCI. Percentages circulating monocytes plasma HIV...
Background Excellent adherence to tuberculosis (TB) treatment is critical cure TB and avoid the emergence of resistance. Wirelessly observed therapy (WOT) a novel patient self-management system consisting an edible ingestion sensor (IS), external wearable patch, paired mobile device that can detect digitally record medication ingestions. Our study determined accuracy detection in clinical home settings using WOT subsequently compared, randomized control trial (RCT), confirmed daily persons...
Abstract Hispanics are the fastest growing ethnicity in United States, yet there limited well-validated neuropsychological tools Spanish, and an even greater paucity of normative standards representing this population. The Spanish NIH Toolbox Cognition Battery (NIHTB-CB) is a novel neurocognitive screener; however, original norms were developed combining Spanish- English-versions battery. We for NIHTB-CB, fully adjusting demographic variables based entirely on Spanish-speaking sample. A...
Aging and HIV have adverse effects on the central nervous system, including increased inflammation neural injury confer risk of neurocognitive impairment (NCI). Previous research suggests nonacute cannabis in general population are or null. However, context aging HIV, use may exert beneficial due to its anti-inflammatory properties. In current study, we examined independent interactive NCI potential moderation these by age.
Objective: This study examined the influence of Hispanic ethnicity and language/cultural background on performance NIH Toolbox Cognition Battery (NIHTB-CB). Method: Participants included healthy, primarily English-speaking (n = 93; Hispanic-English), Spanish-speaking Hispanic-Spanish), English speaking Non-Hispanic white NH white) adults matched age, sex, education levels. All participants were in national norming project completed Fluid Crystallized components NIHTB-CB. T-scores...
Optimal antiretroviral therapy (ART) effectiveness depends on medication adherence, which is a complex behavior with many contributing factors, including neurocognitive function. Pharmacy refill records offer promising and practical tool to assess adherence.A substudy of the CHARTER (CNS HIV Anti-Retroviral Therapy Effects Research) study was conducted at Johns Hopkins University (JHU) Washington. were primary method measure ART indexed "sentinel" drug highest central nervous system...
Author(s): Watson, Caitlin Wei-Ming; Sundermann, Erin E; Hussain, Mariam A; Umlauf, Anya; Thames, April D; Moore, Raeanne C; Letendre, Scott L; Jeste, Dilip V; Morgan, David J | Abstract: ObjectiveThe causes of neurocognitive and everyday functioning impairment among aging people living with HIV (PLWH) are multifactorial. Exposure to stress trauma can result in deficits via activation neurological other biological mechanisms.MethodPLWH (n = 122) persons without 95), 35-65 years age,...
Objective Verbal fluency tests are sensitive to various disorders affecting the central nervous system and commonly included in neuropsychological evaluations. We aimed develop normative data for two verbal a sample of native Spanish-speakers living US-Mexico border region.Method Participants 254 adults from Neuropsychological Norms Border Region Spanish (NP-NUMBRS) Project (Age: range = 19–60; Education: 0–20, 59% female). completed (i.e., letter [PMR] semantic/category [Animal Naming]) as...
Abstract Objective: Recent cannabis exposure has been associated with lower rates of neurocognitive impairment in people HIV (PWH). Cannabis’s anti-inflammatory properties may underlie this relationship by reducing chronic neuroinflammation PWH. This study examined relations between use and inflammatory biomarkers cerebrospinal fluid (CSF) plasma, cognitive correlates these within a community-based sample Methods: 263 individuals were categorized into four groups: HIV− non-cannabis users ( n...
With increasing medicinal and recreational cannabis legalization, there is a public health need for effective unbiased evaluations determining whether driver impaired due to Δ9-tetrahydrocannabinol (THC) exposure. Field sobriety tests (FSTs) are key component of the gold standard law enforcement officer-based evaluations, yet controlled studies inconclusive regarding their efficacy in detecting person under influence THC.