A5082221284- Mental Health and Patient Involvement
- interferon and immune responses
- Health Policy Implementation Science
- Ocular Diseases and Behçet’s Syndrome
- Melanoma and MAPK Pathways
- Survey Methodology and Nonresponse
- Health Systems, Economic Evaluations, Quality of Life
- RNA Research and Splicing
- Focus Groups and Qualitative Methods
- Social Media in Health Education
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal Disorders and Rehabilitation
- Empathy and Medical Education
- Prostate Cancer Treatment and Research
- Genomics and Rare Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gout, Hyperuricemia, Uric Acid
- Ethics in Clinical Research
- Interdisciplinary Research and Collaboration
- Patient-Provider Communication in Healthcare
- Autoimmune and Inflammatory Disorders
- Ubiquitin and proteasome pathways
- Climate Change Communication and Perception
University College Dublin
2016-2024
National Children’s Research Centre
2021-2024
Children's Health Ireland at Crumlin
2024
Trinity College Dublin
2011-2016
Institut Curie
2012
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2012
Universitat Autònoma de Barcelona
2012
St. James's Hospital
2012
Involving patients in research broadens a researcher's field of influence and may generate novel ideas. Preclinical is integral to the progression innovative healthcare. These are not patient-facing disciplines implementing meaningful public patient involvement (PPI) can be challenge. A discussion forum thematic analysis identified key challenges for preclinical researchers. In response we developed "PPI Ready" planning canvas. For contemporaneous evaluation involvement, psychometric...
Early career researchers (ECRs) are important stakeholders leading efforts to catalyze systemic change in research culture and practice. Here, we summarize the outputs from a virtual unconventional conference (unconference), which brought together 54 invited experts 20 countries with extensive experience ECR initiatives designed improve practice of science. Together, drafted 2 sets recommendations for (1) ECRs directly involved or activities practice; (2) who wish support these efforts....
Abstract Background The University College Dublin (UCD) Public and Patient Invovlement (PPI) ignite program is focused on embedding PPI in health social care related research, education training, professional practice administration. During a knowledge sharing event challenges were noted during the pre-commencement stage of research projects. This includes time before projects/partnership starts or when funding being applied for. As response, we agreed there was need to spend developing...
Overtreatment of low-grade prostate cancer is a recognised problem for clinicians and patients. However, under-treatment runs the risk missing opportunity cure in those who could benefit. Identification new biomarkers disease progression, including metastases, required to better stratify appropriately treat these The ability predict if will recur an important clinical question that would impact treatment options Studies other cancers have associated MARCKS with metastasis.Tissue microarrays...
Monogenic Behçet's disease (BD)-like conditions are increasingly recognized and to date have been found predominantly involve loss-of-function variants in TNFAIP3. This study was undertaken identify genetic pathobiologic mechanisms associated with a BD-like mucocutaneous ulcerative syndrome neuromyelitis optica (NMO) occurring 3 generations of an Irish family (n = 5 cases familial controls).Whole-exome sequencing used potential pathogenic affected members determine segregation between...
Background Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number mechanisms contribute to this cell suppression, such as activation-induced death trafficking out the peripheral circulation into diseased lungs. The extent which Mtb human macrophages affects viability however, is not well characterised. Methodology/Principal Findings We found...
MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length that function as regulators of gene expression. Dysregulation miRNAs has been associated with initiation and progression oncogenesis humans. Our group previously described a unique miRNA expression signature, including the MIR200 family member MIR141, which can differentiate papillary thyroid cancer (PTC) cell lines from control line. An investigation into MIR141 series archival malignancies [n = 140; classic...
Abstract Context Public and patient involvement is increasingly becoming an expectation of research funders policy makers. Not all areas health are public‐facing. Here, we outline approach for building the skills developing relationships required downstream public in pre‐clinical adolescent rheumatology research. Objective To design a methodology improving researcher‐adolescent communications specifically aimed at mutual relationship PPI. Deliberate effective preparation advance to improve...
<ns4:p><ns4:bold>Background:</ns4:bold></ns4:p><ns4:p> Rare diseases are individually rare, but collectively these conditions common. Research on rare currently focused disease-specific needs rather than a life-course perspective. The Disease Partnership (RAinDRoP) was established in 2018 to bring together wide variety of diverse voices the disease community Ireland and form research partnership.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold></ns4:p><ns4:p> A participatory...
Background Between 20% and 35% of prostate cancer (PCa) patients who undergo treatment with curative intent (ie, surgery or radiation therapy) for localized disease will experience biochemical recurrence (BCR). Alterations in the insulin‐like growth factor (IGF) axis PTEN expression have been implicated development progression several human tumors including PCa. We examined insulin receptor (INSR), IGF‐1 (IGF‐1R), PTEN, AKT radical prostatectomy tissue developed BCR post‐surgery. Methods...
Abstract Genetic variants in C5orf30 have been associated with development of the autoimmune conditions primary biliary cirrhosis and rheumatoid arthritis. In arthritis, expression is cell-specific, highest found macrophages synovial fibroblasts. highly expressed inflamed joints a negative regulator tissue damage mouse model inflammatory Transcriptomic analysis from ultrasound-guided biopsy well characterized clinical cohort newly diagnosed, disease-modifying antirheumatic drugs–naive...
Background Environmental sensitivity is commonly reported by people with fibromyalgia syndrome. People living syndrome frequently report hypersensitivity to noxious and non-noxious sensations. To date, there has been little empirical validation of sensory disturbance triggers. used as a diagnostic feature only in Bennet's alternative criteria for diagnosis fibromyalgia, where it was ranked the second most important components diagnosis, after number pain sites. The aim this study use...
Oncogenic mutations in BRAF are common melanoma and thyroid carcinoma drive constitutive activation of the MAPK pathway. Molecularly targeted therapies this pathway improves survival compared to chemotherapy; however, responses tend be short-lived as resistance invariably occursCell line models carcinoma, +/− BRAFV600E activating mutation, were treated with MEK inhibitor PD0325901. Treated naive samples assayed for expression key members Global microRNA profiling resistant cells was...
Public and Patient Involvement can align both the research process its outcomes with values, needs expectations of society. By fostering design inclusive, engaged, sustainable practices, integrity be improved. Devolving power to involve patients relevant publics in deliberative decision making produce better outcomes. Disabled people are often categorized as "Hard Reach." There is a varied complex ecosystem societal challenges living disability that reinforce this. However, if researchers...
Background: The Rare Disease Research Partnership (RAinDRoP) was established in 2018 to bring together a wide variety of diverse voices the rare disease community Ireland and form research partnership. This approach enabled clinicians, patients, carers researchers work identify top priorities for diseases, which focused on life-course perspective rather than disease-specific need. Methods: A participatory multiple phase used diseases. process involved three main phases: Phase I, Public...
rs26232, located in intron one of C5orf30, is associated with the susceptibility to and severity rheumatoid arthritis (RA). Here, we investigate relationship between this variant biological activities synovial fibroblasts (RASFs). RASFs were isolated from knee joints 33 RA patients. The rs26232 genotype was determined cellular migration, invasion, apoptosis compared using vitro techniques. production adhesion molecules, chemokines, proteases measured by ELISA or flow cytometry. Cohort...
Abstract Expression of the macrophage immunometabolism regulator gene (MACIR) is associated with severity autoimmune disease pathology and regulation biology through unknown mechanisms. The encoded 206 amino acid protein lacks homology to any characterized sequence a disordered according structure prediction algorithms. To identify interactions MACIR proteins from all subcellular compartments, membrane solubilization buffer employed, that together high affinity EF hand based pull down...
Fibromyalgia syndrome (FMS) is the most common chronic widespread pain condition in rheumatology. Until recently, no clear pathophysiological mechanism for fibromyalgia had been established, resulting management challenges. Recent research has indicated that serum immunoglobulin Gs (IgGs) may play a role FMS. We undertook prioritisation exercise to identify pertinent approaches lead clinically implementable outputs.
Background: Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity.A number mechanisms contribute to this cell suppression, such as activation-induced death trafficking out the peripheral circulation into diseased lungs.The extent which Mtb human macrophages affects viability however, is not well characterised.Methodology/Principal Findings: We found...
Metastatic prostate cancer is treated with androgen ablation therapy but progress to castrate resistant (CRPC). This study aimed investigate the role of CUX1 in CRPC using clinical samples and vitro models. expression was increased androgen-independent cells compared androgen-sensitive cells. The multi-isoform nature makes it difficult assay tissue microarrays as there no epitope able distinguish many isoforms for immunohistochemistry. Using surrogate markers, we found differential between...