A5100458103- Autism Spectrum Disorder Research
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Neuroscience and Music Perception
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Face Recognition and Perception
- Reading and Literacy Development
- Hearing, Cochlea, Tinnitus, Genetics
- Language Development and Disorders
- Family and Disability Support Research
- Neuroscience and Neural Engineering
- Child Development and Digital Technology
- Williams Syndrome Research
- Pain Management and Opioid Use
- Nerve injury and regeneration
- Behavioral and Psychological Studies
- Pediatric Pain Management Techniques
- Blind Source Separation Techniques
- Neurofibromatosis and Schwannoma Cases
- Ziziphus Jujuba Studies and Applications
- Sleep and Wakefulness Research
- Neural and Behavioral Psychology Studies
- Pain Management and Placebo Effect
Imaging Center
2019-2025
Children's Hospital of Philadelphia
2019-2025
Hoseo University
2022
Temple University
2013-2021
University of Maryland, Baltimore
2012
University of Toronto
2006
Recent studies suggest that proliferation in the adult forebrain subventricular zone increases response to a stroke and intraventricular infusions of growth factors enhance this response. The potential for factor regenerate damaged motor cortex promote recovery function after has not been examined. Here, we report epidermal erythropoietin together, but individually, substantial regeneration cerebral reverse impairments spontaneous skilled tasks, rat model stroke. Cortical functional occurred...
Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary cortex processing, have been reported in children who autism spectrum disorder (ASD). Some studies an association between delays these responses language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during processing minimally or nonverbal (ASD-MVNV)—children no speech often significant To...
Abstract Age‐related changes in resting‐state (RS) neural rhythms typically developing children (TDC) but not with autism spectrum disorder (ASD) suggest that RS measures may be of clinical use ASD only for certain ages. The study examined this issue via assessing peak alpha frequency (PAF), a measure previous studies, have indicated as abnormal ASD. magnetoencephalographic (MEG) data were obtained from 141 TDC (6.13–17.70 years) and 204 (6.07–17.93 years). A source model 15 regional sources...
Abstract Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded magnetoencephalography (MEG), have been reported in verbal children with ASD. Association clinical measures indicates that delayed MMF components are associated poorer language and communication performance. At present, little is known about correlates of skills extremely impaired ( minimally‐verbal/non‐verbal) who ASD: ASD‐MVNV. It hypothesized delays observed language‐impaired but...
We and others have demonstrated the resting-state (RS) peak alpha frequency (PAF) as a potential clinical marker for young children with autism spectrum disorder (ASD), previous studies observing higher PAF in school-age ASD versus typically developing (TD) children, well an association between RS measures of processing speed TD but not ASD. The brain mechanisms associated these findings are unknown. A few found that more mature optic radiation white matter is PAF. Other reported neural...
The M50 and M100 auditory evoked responses reflect early processes in the primary/secondary cortex. Although previous studies have been conducted on individuals with autism spectrum disorder (ASD) indicate disruption of encoding simple sensory information, analogous investigations neural correlates processing through development from children into adults are very limited. Magnetoencephalography was used to record signals arising left right superior temporal gyrus during presentation tones...
The infant auditory system rapidly matures across the first years of life, with a primary goal obtaining ever-more-accurate real-time representations external world. Our understanding how left and right cortex neural processes develop during infancy, however, is meager, few studies having statistical power to detect potential hemisphere sex differences in primary/secondary maturation. Using magnetoencephalography (MEG) cross-sectional study design, P2m responses pure tones were examined 114...
In a relaxed and awake state with the eyes closed, 8-12 Hz neural oscillations are dominant rhythm, most prominent in parietal-occipital regions. Resting-state (RS) alpha is associated processing speed also thought to be central how networks process information. Unfortunately, RS eyes-closed (EC) exam can only used individuals who remain their closed for an extended period. As such, infants, toddlers, intellectual disabilities usually excluded from studies. Previous research suggests...
Little is known about the neural processes associated with attending to social stimuli during infancy and toddlerhood. Using infant magnetoencephalography (MEG), fusiform gyrus (FFG) activity while processing Face Non-Face was examined in 46 typically developing infants 3 24 months old (28 males). Several findings indicated FFG maturation throughout first two years of life. First, right responses decreased as a function age. Second, hemispheric specialization face developed somewhat slowly,...
Neuroimaging research on individuals who have autism spectrum disorder (ASD) has historically been limited primarily to those with age-appropriate cognitive and language performance. Children abilities are frequently excluded from such neuroscience given anticipated barriers like tolerating the loud sounds associated magnetic resonance imaging remaining still during data collection. To better understand brain function across full range of ASD there is a need (1) include performance in...
Functional brain markers that can inform research on abnormalities, and especially those ready to facilitate clinical work such will need show not only considerable sensitivity specificity but enough consistency with respect developmental course their validity in individual cases be trusted. A challenge establishing may differences course. The present study examined auditory cortex activity children at an age when changes the 50 ms (M50) 100 (M100) components are prominent better understand...
Infant and young child electrophysiology studies have provided information regarding the maturation of face-encoding neural processes. A limitation previous research is that very few examined processes in children 12–48 months age, a developmental period characterized by rapid changes ability to encode facial information. The present study sought fill this gap literature via longitudinal examining primary node network—the left right fusiform gyrus (FFG). Whole-brain magnetoencephalography...
Abstract In school-age children, the myelination of auditory radiation thalamocortical pathway is associated with latency evoked responses, axons facilitating rapid propagation acoustic information. Little known regarding this system function-structure association in infants and toddlers. The present study tested hypothesis that maturation white-matter microstructure (e.g., fractional anisotropy (FA); measured using diffusion-weighted MRI) infant response (P2m magnetoencephalography, MEG) a...
Abstract Our understanding of how visual cortex neural processes mature during infancy and toddlerhood is limited. Using magnetoencephalography (MEG), the present study investigated development evoked responses (VERs) in both cross-sectional longitudinal samples infants toddlers 2 months to 3 years. Brain space analyses focused on N1m P1m latency, as well N1m-to-P1m amplitude. Associations between VER measures developmental quotient (DQ) scores cognitive/visual fine motor domains were also...
Youth with neurofibromatosis type I (NF1) demonstrate high rates of Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity (ADHD), which often have overlapping behaviors. Diagnostic clarity is important to guide services. This study evaluated ASD classification in NF1 using various methods whether those ADHD suspicion more social challenges associated ASD.
Many plants have been used in Korean medicine for treating insomnia. However, scientific evidence their sedative activity has not fully investigated. Thus, this study was carried out to investigate the effects of extracts medicinal plants, including Yukmijihwang-tang and its various modified forms through 5-HT2c receptor binding assay, further confirm sleep-promoting underlying neural mechanism rats utilizing electroencephalography (EEG) analysis. Enzyme-linked immunosorbent assay (ELISA)...
본 연구는 초기 청소년이 지각한 부모양육태도가 사이버폭력 가해경험에 미치는 영향에서 공격성의 매개효과와 교사 및 또래관계의 조절된 매개효과를 검증함으로써 청소년의 사이버폭력을 예방하기 위한 실천적 개입의 기초자료로 활용하는데 그 목적이 있다. 이를 위해 한국아동·청소년 패널조사 2018(Korean Children and Youth Panel Survey 2018) 중학교 1학년 1차년도 자료를 활용하였으며, 자료분석은 SPSS 16.0, Process v.3.5 for SPSS를 활용하였다. 연구결과는 다음과 같다. 첫째, 부모양육태도와 가해경험과의 관계에서 공격성은 완전매개효과를 가지는 것으로 확인되었다. 둘째, 긍정적부모양육태도가 공격성을 매개로 또래관계는 각각 보였다. 이러한 분석결과를 바탕으로 사이버 폭력을 개입방안을 제시하였다.