A5081122389- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Hearing Loss and Rehabilitation
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- MRI in cancer diagnosis
- Neuroscience and Neural Engineering
- Reading and Literacy Development
- Atomic and Subatomic Physics Research
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Face Recognition and Perception
- Pediatric Urology and Nephrology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neonatal and fetal brain pathology
- Congenital heart defects research
- Hearing, Cochlea, Tinnitus, Genetics
- Multisensory perception and integration
- Schizophrenia research and treatment
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Imaging Center
2015-2025
Philadelphia University
2010-2022
Simons Foundation
2021
Huntington Hospital
2017
Raymond G. Murphy VA Medical Center
2015
University of New Mexico
2001-2015
University of Hawaiʻi at Mānoa
2015
University of Illinois Urbana-Champaign
2003-2014
The aim of this work is to characterize quantitatively the performance a body techniques in frequency domain for estimation cortical connectivity from high-resolution EEG recordings different operative conditions commonly encountered practice. Connectivity pattern estimators investigated are Directed Transfer Function (DTF), its modification known as direct DTF (dDTF) and Partial Coherence (PDC). Predefined patterns were simulated then retrieved by application DTF, dDTF, PDC methods....
Abstract Motivated by auditory and speech deficits in autism spectrum disorders (ASD), the frequency dependence of superior temporal gyrus (STG) 50 msec (M50) 100 (M100) neuromagnetic evoked field responses children with ASD typically developing controls were evaluated. Whole‐cortex magnetoencephalography (MEG) was obtained from 17 25 ASD. Subjects presented tones frequencies 200, 300, 500, 1,000 Hz, left right STG M50 M100 activity examined. No latency or amplitude Group differences...
Electrocorticographic (ECoG) spectral patterns obtained during language tasks from 12 epilepsy patients (age: 12–44 years) were analysed in order to identify and characterize cortical areas. ECoG 63 subdural electrodes (500 Hz/channel) chronically implanted over frontal, parietal temporal lobes examined. Two performed. During the first task, listened a series of 50 words preceded by warning tones, asked repeat each word. second memory subjects heard task randomly mixed with new word only if...
Anxiety is characterized by cognitive biases, including attentional bias to emotional (especially threatening) stimuli. Accounts differ on the time course of attention threat, but literature generally confounds valence and arousal overlooks gender effects, both addressed in present study. Nonpatients high self-reported anxious apprehension, arousal, or neither completed an emotion-word Stroop task during event-related potential (ERP) recording. Hypotheses differentiated preferential...
Sensory gating assessed via EEG in a paired-click paradigm has often served as neurophysiological metric of attentional function schizophrenia. However, the standard measure sensory using P50 component at electrode Cz does not foster differential assessment left and right hemisphere contributions. Magnetoencephalography (MEG) is complementary to EEG, its analogous M50 may be better suited for localization analysis such lateralized cortical generators. The authors hypothesized that 1)...
Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild TBI (mTBI) can be difficult to detect using conventional MRI or CT. Injured tissues mTBI patients generate abnormal slow-waves (1–4 Hz) that measured localized by resting-state magnetoencephalography (MEG). In this study, we develop voxel-based whole-brain MEG slow-wave imaging approach for detecting abnormality with on single-subject basis. A normative database source...
Findings of auditory abnormalities in children with autism spectrum disorder (ASD) include delayed superior temporal gyrus responses, pre- and post-stimulus (STG) oscillatory abnormalities, atypical hemispheric lateralization. These are likely associated abnormal brain maturation. To better understand changes activity as a function age, the present study investigated associations between age STG time-domain time-frequency neural activity. While 306-channel magnetoencephalography (MEG) data...
Fetal MRI at 3 T is emerging as a promising modality for evaluating fetal anatomy. The objective of this study was to compare the quality images obtained with commonly used imaging sequences 1.5 and T. We hypothesized that visualization anatomic detail structures would be better than T.A retrospective search radiology department database our institution identified 58 examinations performed evaluate body abnormalities during period from July 2012 February 2014. A blind comparison conducted...
<h3>BACKGROUND AND PURPOSE:</h3> The auditory radiation crosses other white matter tracts and cannot reliably be delineated or quantitatively assessed with DTI fiber tracking. This study investigates whether HARDI tracking can used to robustly delineate the full extent of tract. <h3>MATERIALS METHODS:</h3> (64-direction, <i>b</i>=3000 s/mm<sup>2</sup>) (30-direction, <i>b</i>=1000 were acquired from 25 control participants between 8 26 years old. Probabilistic was performed starting filter...
Individuals with autism spectrum disorder (ASD) show atypical brain activity, perhaps due to delayed maturation. Previous studies examining the maturation of auditory electrophysiological activity have been limited their use cross-sectional designs. The present study took a first step in magnetoencephalography (MEG) evidence abnormal response ASD via longitudinal design. Initially recruited for previous study, 27 children and nine typically developing (TD) children, aged 6- 11-years-old,...
Major theories on the neural basis of schizophrenic core symptoms highlight aberrant salience network activity (insula and anterior cingulate cortex), prefrontal hypoactivation, sensory processing deficits as well an impaired connectivity between temporal cortices. The mismatch negativity is a potential biomarker schizophrenia its reduction might be consequence each these mechanisms. In contrast to previous electroencephalographic studies, functional magnetic resonance imaging may...
Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary cortex processing, have been reported in children who autism spectrum disorder (ASD). Some studies an association between delays these responses language impairment. However, as most prior research has focused on verbal individuals with ASD without cognitive impairment, rather little is known about neural activity during processing minimally or nonverbal (ASD-MVNV)—children no speech often significant To...
Abstract Age‐related changes in resting‐state (RS) neural rhythms typically developing children (TDC) but not with autism spectrum disorder (ASD) suggest that RS measures may be of clinical use ASD only for certain ages. The study examined this issue via assessing peak alpha frequency (PAF), a measure previous studies, have indicated as abnormal ASD. magnetoencephalographic (MEG) data were obtained from 141 TDC (6.13–17.70 years) and 204 (6.07–17.93 years). A source model 15 regional sources...
Abnormal 50- and 100-msec event-related brain activity derived from paired-click procedures are well established in schizophrenia. There is little agreement on whether group differences the ratio score, i.e., of EEG amplitude after second stimulus (S2) to first (S1), reflect an encoding or gating abnormality. In addition, functional implications remain unclear. present study, magnetoencephalography (MEG) were used examine measures cognitive correlates activity.
Abstract We describe a set of computational tools able to estimate cortical activity and connectivity from high‐resolution EEG fMRI recordings in humans. These methods comprise the estimation using realistic geometry head volume conductor models distributed source models, followed by evaluation between regions interest coincident with Brodmann areas via use Partial Directed Coherence. Connectivity patterns estimated on surface different frequency bands are then imaged interpreted measures...
A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this is altered psychopathology, despite evidence that depression anxiety are associated with control impairments. Functional MRI dense-array event-related brain potential (ERP) data were collected separate sessions from 100 participants during a color-word Stroop task. results guided...