A5100650506- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Face Recognition and Perception
- Advanced Neuroimaging Techniques and Applications
- Multisensory perception and integration
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- Neurological disorders and treatments
- Hearing Loss and Rehabilitation
- Axon Guidance and Neuronal Signaling
- Genetics, Aging, and Longevity in Model Organisms
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Reading and Literacy Development
- Atomic and Subatomic Physics Research
- MXene and MAX Phase Materials
- Williams Syndrome Research
- Nerve injury and regeneration
- Image and Video Quality Assessment
Hebei North University
2024-2025
Children's Hospital of Philadelphia
2014-2024
Imaging Center
2018-2024
University of Pennsylvania
2014-2024
Xiamen University Malaysia
2024
Nantong University
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Air Force Medical University
2022-2023
Shaanxi University of Chinese Medicine
2022-2023
The formation of the complex network architecture neural systems is subject to multiple structural and functional constraints. Two obvious but apparently contradictory constraints are low wiring cost high processing efficiency, characterized by short overall length a small average number steps, respectively. Growing evidence shows that networks results from trade-off between physical value topology. However, relationship these competing topology not well understood quantitatively. We...
Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild TBI (mTBI) can be difficult to detect using conventional MRI or CT. Injured tissues mTBI patients generate abnormal slow-waves (1–4 Hz) that measured localized by resting-state magnetoencephalography (MEG). In this study, we develop voxel-based whole-brain MEG slow-wave imaging approach for detecting abnormality with on single-subject basis. A normative database source...
Short-form videos are popular worldwide as a thriving form of entertainment. Its fragmentation pattern, which presents users with intensive and engaging information, might lead to addiction adverse effects. This study aims investigate the effect short-form on users' attention, including attention while watching ability attentional concentration after time. Users addicted or non-addicted were screened participate in video task Stroop based eye-tracking technology. The results showed that...
Background Computer-generated virtual faces become increasingly realistic including the simulation of emotional expressions. These can be used as well-controlled, and dynamic stimuli in emotion research. However, validity facial expressions comparison to natural displays still needs shown for different emotions age groups. Methodology/Principal Findings Thirty-two healthy volunteers between 20 60 rated pictures human characters (avatars) with respect expressed emotions: happiness, sadness,...
Human cognition and behaviors depend upon the brain's functional connectomes, which vary remarkably across individuals. However, whether how connectome individual variability architecture is structurally constrained remains largely unknown. Using tractography- morphometry-based network models, we observed spatial convergence of structural variability, with higher in heteromodal association regions lower primary regions. We demonstrated that significantly predicted by a unifying pattern this...
Background Increased temporal and frontal slow-wave delta (1–4 Hz) theta (4–7 activities are the most consistent resting-state neural abnormalities reported in schizophrenia. The lobe is associated with negative symptoms cognitive abilities such as attention, impaired attention poor functional capacity. Aims To establish whether dysfunction, indexed by slowing, would be impairments. Method Eyes-closed magnetoencephalography data were collected 41 participants schizophrenia 37 healthy...
Mild traumatic brain injury (mTBI) is common in adolescents. Magnetoencephalography (MEG) studies (primarily reporting on adult males) have demonstrated abnormal resting-state (RS) activity mTBI. The present study sought to identify RS abnormalities male and female adolescents with mTBI (no previous no DSM-5 diagnosis) identified from an outpatient specialty care concussion program setting as a basis for evaluating potential clinical utility. Visit 1 MEG data were obtained 46 (mean age: 15.4...
Accurate staging of Alzheimer's disease (AD) pathology is crucial for therapeutic trials and prognosis, but existing fluid biomarkers lack specificity, especially assessing tau deposition severity, in amyloid-beta (Aβ)-positive patients. We analyze cerebrospinal (CSF) samples from 136 participants the Disease Neuroimaging Initiative using more than 6,000 proteins. apply machine learning to predict AD pathological stages defined by amyloid positron emission tomography (PET). identify two...
ABSTRACT Background Deep brain stimulation (DBS) is a novel therapy for severe Alzheimer's disease (AD). However, there an ongoing debate regarding the optimal target DBS, particularly fornix and basal ganglia of Meynert (NBM). Objective This study aimed to investigate safety efficacy DBS AD compare NBM as potential targets. Methods We conducted prospective, nonrandomized clinical involving 20 patients with (MMSE score 0 10, CDR level 3) from January 2015 August 2022, comprising 12 males...
The M50 and M100 auditory evoked responses reflect early processes in the primary/secondary cortex. Although previous studies have been conducted on individuals with autism spectrum disorder (ASD) indicate disruption of encoding simple sensory information, analogous investigations neural correlates processing through development from children into adults are very limited. Magnetoencephalography was used to record signals arising left right superior temporal gyrus during presentation tones...
EDITORIAL article Front. Hum. Neurosci., 21 October 2014Sec. Cognitive Neuroscience Volume 8 - 2014 | https://doi.org/10.3389/fnhum.2014.00822
The infant auditory system rapidly matures across the first years of life, with a primary goal obtaining ever-more-accurate real-time representations external world. Our understanding how left and right cortex neural processes develop during infancy, however, is meager, few studies having statistical power to detect potential hemisphere sex differences in primary/secondary maturation. Using magnetoencephalography (MEG) cross-sectional study design, P2m responses pure tones were examined 114...
Normal functioning in many realistic complex dynamical systems, such as neural networks, requires coherence and synchronization for collective actions of network components. However, strong the whole is often related to pathological situations. A regime between enabling both segregation subsystems integration a thus desirable. Here, we characterize this by complexity patterns study its relationship heterogeneous modular architecture oscillators. We show that these networks possess broad...
Abstract Although the 40 Hz auditory steady‐state response (ASSR) is of clinical interest, construct validity EEG and MEG measures ASSR cortical microcircuits unclear. This study evaluated several metrics by leveraging findings (a) an association between age in left but not right hemisphere, (b) right‐ > left‐hemisphere differences strength ASSR. The contention that, if analysis method does demonstrate a relationship or hemisphere differences, then obtained likely have low validity....
Abstract Higher association cortices as well unisensory areas can support multisensory integration [D. Senkowski et al. (2008) Trends Neurosci. , 31, 401–409]. The present study investigated whether audiovisual of emotional information emerges early at or later higher cortices. Emotional stimuli were presented in three blocks: (AV), auditory (A) and visual (V). Eighteen participants performed a delayed recognition task (happy, angry neutral prosody and/or facial expression) while whole‐brain...
Abstract Vascular dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). While sodium essential for maintaining vascular function, its role AD pathology remains unclear. We included 353 participants from Disease Neuroimaging Initiative (ADNI), assessing serum levels, cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers, magnetic resonance imaging (MRI), cognitive function. An independent sample ( N = 471) with available CSF sodium‐related...