A5102876931- Trace Elements in Health
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Heavy Metal Exposure and Toxicity
- Liver Disease and Transplantation
- Selenium in Biological Systems
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Synthesis and Biological Activity
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Food Allergy and Anaphylaxis Research
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Abdominal Trauma and Injuries
- Advanced Glycation End Products research
- Vitamin C and Antioxidants Research
- Arsenic contamination and mitigation
- Osteoarthritis Treatment and Mechanisms
- Vasculitis and related conditions
- Signaling Pathways in Disease
- Peroxisome Proliferator-Activated Receptors
Xi'an Jiaotong University
2007-2023
Jiaozuo University
2021-2023
University of Louisville
2009-2012
Wenzhou Medical University
2010-2012
Public Health Department
2009
University of Louisville Hospital
2008
Previous studies have demonstrated that copper up-regulates hypoxia-inducible factor 1 (HIF-1). The present study was undertaken to test the hypothesis is required for HIF-1 activation. Treatment of HepG2 cells with a chelator tetraethylenepentamine (TEPA) or short interfering RNA targeting chaperone superoxide dismutase (CCS) suppressed hypoxia-induced activation HIF-1. Addition excess relieved suppression by TEPA, but not CCS gene silencing, indicating requirement HIF-1, which...
OBJECTIVE Glycogen synthase kinase (GSK)-3β plays an important role in cardiomyopathies. Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice were highly resistant to diabetes-induced cardiomyopathy. Therefore, we investigated whether metallothionein cardiac protection against diabetes is mediated by inactivation of GSK-3β. RESEARCH DESIGN AND METHODS Diabetes was induced with streptozotocin both MT-TG and wild-type mice. Changes energy metabolism–related molecules, lipid...
Abstract Background The purpose of this study was to investigate the typing adenovirus (AdV) infection in children hospitalized with acute respiratory tract (ARTI) and its clinical characteristics. Methods Samples from 7832 ARTIs January 2021 June 2022 were tested by multiplex PCR for AdV. AdV hex neighborhood genes amplified sequenced nested PCR. Results Three hundred twenty-eight cases positive rate 4.48% (328/7832). No statistical difference detection observed different ages ( P >...
Metallothionein (MT) protects against heavy metal-induced cellular damage and may participate in other fundamental physiological pathological processes, such as antioxidation, proliferation, cell survival. Previously, we have shown that elevation of MT by transgene or induction with zinc the heart diabetic cardiomyopathy mechanisms antidiabetes-induced oxidative stress inactivation glycogen synthase kinase-3, which mediates glucose metabolism. We also reported overexpression rescued...
NO plays an important role in cartilage destruction by inducing apoptosis of chondrocytes. Here we investigated the c-Jun N-terminal kinase (JNK) signal transduction pathways induced donor sodium nitroprusside (SNP) rabbit articular We used Annexin V-FITC/PI flow cytometry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL) to detect rate. The expressions p38, NF-κB p65, caspase-3 p53 genes at protein levels were measured Western blotting assay....
Purpose . To investigate the preventive effect of resveratrol (RES) on formation portal vein system thrombosis (PVST) in a rat fibrosis model. Methods A total 64 male SD rats, weighing 200–300 g, were divided into five groups: Sham operation, Splenectomy I, II, RES, and low molecular weight heparin (LMWH), with former two groups as nonfibrosis controls. Blood samples subjected to biochemical assays. Platelet apoptosis was measured by flow cytometry. All rats euthanized for PVST detection one...
Tetrandrine (Tet), a traditional Chinese herbal medicine extract, exhibits anti-cancer effect on many types of cancer. Nonetheless, the action mechanism Tet in gastric cancer (GC) is still largely unclear. In current study, proliferation, invasion, and migration BGC-823 MKN-45 cells were effectively suppressed by treatment dose-dependent manner. Moreover, expression proliferation-associated protein PCNA, interstitial cell phenotype N-cadherin, extracellular matrix-associated MMP-2 MMP-9...
Ki-67 is one of the most useful markers to evaluate cell proliferative activity and has been widely used in tumor treatment research. However, its role human laryngeal carcinoma remains poorly defined. The aim present study was investigate expression squamous effect gene silencing by small interfering (si)RNA on proliferation laryngocarcinoma HEp2 cells. Immunohistochemistry reverse transcription-quantitative polymerase chain reaction were performed examine tissues adjacent non-cancer from...
The amino acid-based formulae were extensively added to diet of children for the treatment Henoch-Schonlein purpura (HSP), and nutrition growth situation evaluated after giving new dietary intervention. Patients randomly divided into restricted group (n=30) guidance (n=30). Besides, 30 cases with bronchiolitis who had normal selected as control group. questionnaire was designed record types intakes various foods taken by every day, intake levels nutrients analyzed. Physical examination,...
Previous studies have shown that metallothionein (MT) protects against diabetic cardiomyopathy (DCM) in mice. The current study was undertaken to test the hypothesis protective role of MT DCM is mediated by hypoxia‐inducible factor ‐1 (HIF‐1) pathway leading an increased angiogenesis and a normalization glucose metabolism cardiac specific over‐expression mouse model rat embryonic fibroblast H9c2 cell line. Streptozotocin‐induced diabetes decreased HK‐II protein level, HIF target important...
The purpose of this study was to examine whether or not MT affects HIF‐1α activity in the heart diabetic mice and cardiac cells leading regulation angiogenic factors glycolytic enzymes. Diabetes decreased VEGF HK‐II protein level mice; both cardiac‐specific over‐expression could relieve suppression. Further analysis showed that increased heart. rescues transcriptional normalization cardiomyocytes under conditions. (Supported part by an American Association Grant 07‐07‐JF‐23)