A5088693454- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Vagus Nerve Stimulation Research
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Neurosurgical Procedures and Complications
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Musculoskeletal pain and rehabilitation
- Photodynamic Therapy Research Studies
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Facial Trauma and Fracture Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Transcranial Magnetic Stimulation Studies
Azienda Ospedaliero Universitaria di Sassari
2018-2024
Ospedale SS. Annunziata
2022
University of Sassari
2021
Twin Cities Orthopedics
2020
Stony Brook University
2020
Neurological Surgery
2020
Università Cattolica del Sacro Cuore
1971-2012
Cosmo Pharmaceuticals (Italy)
2009
Catholic University of America
2005
University of Milan
1997
Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we the effect direct left VNS on HRV in patients with refractory epilepsy.A 24-hour electrocardiogram Holter recording was performed both at baseline after 3 months 8 (age 32 +/- 24 years,...
Abstract Objective To analyse the correlations between olfactory psychophysical scores and serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients. Methods Patients underwent assessment with Connecticut Chemosensory Clinical Research Center test, determination blood inflammatory markers within 10 days clinical onset 60 after. Results Seventy-seven patients were included this study....
The aim of this study was to compare the results two different titanium cranioplasties for reconstructing skull defects: standard precurved mesh versus custom-made prostheses.Retrospective analysis 23 patients submitted cranioplasty between January 2014 and 2019. Ten underwent delayed using prostheses; 13 were treated (ten cranioplasties, three single-stage resection- reconstructions). Demographic, clinical, radiological data recorded. Results complications methods compared, including...
Summary: Purpose: To correlate ictal hyperperfusion single‐photon emission computed tomography (SPECT) area during provoked seizures to the epileptogenic zone (EZ), as defined by depth recordings in adult drug‐resistant patients. Methods: We included study eight epilepsy patients, subjected both noninvasive and invasive (stereo‐electroencephalography, SEEG) presurgical evaluation Epilepsy Surgery Center of Catholic University Rome, from 2001 2003. All patients were interictal SPECT scans...
BACKGROUND: The primary motor cortex, which is part of the corticobasal ganglia loops, may be an alternative option for surgical treatment Parkinson disease. OBJECTIVE: To report on 1-year safety and efficacy unilateral extradural cortex stimulation in METHODS: A quadripolar electrode strip was extradurally implanted over cortex. Stimulation continuously delivered through paddle contralateral to most affected clinical side. Subjects were prospectively evaluated by Unified Parkinson's Disease...
Abstract Background Resection of tumors adjacent to motor pathways carries risks both postoperative deficit and incomplete resection. Our aim was assess usefulness limitations a multimodal strategy that combines intraoperative ultrasound (iUS) guided resection with neurophysiology. Methodology This is prospective study 25 patients brain lesions areas who underwent intracranial surgery assistance the iUS guidance system neurophysiological monitoring mapping. Pathologies treated included 19...
The objective of this study was to compare the efficacy and tolerability lercanidipine slow-release (SR) nifedipine in patients with mild moderate essential hypertension. After a 3-week placebo run-in, 130 aged 18-70 years entered 16-week double-blind (doubledummy) multicenter study. Patients were randomized parallel groups receiving either 10 mg once daily or 20 SR twice for 4 weeks. Dose doubling addition 12.5 hydrochlorothiazide q.d. (titrated 25 non-responders) allowed non-responding...
Cerebral toxoplasmosis is a relatively rare disorder that usually affects immunocompromised patients. The most common scenario occurs among human immunodeficiency virus (HIV)-positive In those patients, the frequent cause of expansive brain lesion and continues to elevated morbidity mortality. typical cases toxoplasmosis, both computed tomography magnetic resonance imaging reveal single/ multiple nodular or ring-enhancing lesions with surrounding edema. Nevertheless, cerebral atypical...
Staphylococcus lugdunensis is an unusually virulent coagulase-negative staphylococcus that has rarely been implicated in central nervous system infections.Two children hospitalized the Neurosurgery Unit developed ventriculitis caused by methicillin-resistant following placement of external ventriculostomy drains. The causative organisms were identified molecular studies. patients recovered without significant sequelae after high doses intrathecal vancomycin.Distinguishing from other species...
Background: DLGNT is a rare tumor, commonly diagnosed in pediatric age; most cases, the pathology presents slow and indolent evolution. We present case report of young adult affected by characterized aggressive atypical behavior. Case Description: A 21-year-old male presented with mild paraparesis hypoesthesia D2 level. MRI scan brain spine showed dorsal intramedullary lesion; diffuse craniospinal leptomeningeal thickening was also present. After week, neurological status deteriorated...
Background: Traumatic intracranial aneurysms (TICA) are often associated with poor prognosis and should be diagnosed as soon possible to prevent delayed hemorrhage high rates of morbidity/mortality related bleeding.Diagnosis requires a index suspicion.The goal treatment is exclude the aneurysm issue surgical or endovascular methods.Case Description: We report case 19-year-old boy who suffered cranio-orbital trauma; 2 weeks after initial trauma he deteriorates new bleeding.Immediate...
Introduction: There are no guidelines about the management of glioblastoma multiforme (GBM) during pregnancy: treatment these patients presents therapeutic and ethical challenges. Case Description: Two patients, respectively, 28 years old at 14 th week gestation with a thalamic GBM 38 fronto-mesial GBM. Patients their relatives were deeply informed natural history potential risks benefits surgery, radiotherapy (XRT), chemotherapy (CTX) for both, mother fetus. The first patient’s will was to...
Painful hand and moving finger treated by wearing a glove