A5007718111- Fatty Acid Research and Health
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Reproductive Biology and Fertility
- Lipid metabolism and biosynthesis
- Infant Nutrition and Health
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Paraoxonase enzyme and polymorphisms
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Sirtuins and Resveratrol in Medicine
- Sperm and Testicular Function
- Ovarian function and disorders
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Amino Acid Enzymes and Metabolism
- Cholesterol and Lipid Metabolism
- Cynara cardunculus studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Phytochemicals and Antioxidant Activities
University of the Basque Country
2012-2025
Hospital Clínico de la Universidad de Chile
2024
BioCruces Health research Institute
2017-2021
Centre for Biomedical Network Research on Rare Diseases
2020
RELX Group (United States)
2020
University of Béjaïa
2019
Providence College
2011
Hannover Re (Germany)
2011
Hospital de Cruces
1998-2005
University of Córdoba
2005
A total of 76 Lactobacillus plantarum and Oenococcus oeni wild strains were recovered from traditionally elaborated Spanish red wines investigated with respect to their response acid pH, lyophilisation, temperature ethanol concentrations which are normally lethal lactic bacteria. Both L. O. able grow at pH 3.2, highly resistant lyophilisation treatment proliferated in the presence up 13% 18 degrees C. Therefore, it is shown that both species tolerant stress conditions similarly strains,...
A sensitive, rapid, ;ind simple method is presented for the simriltiineoris qii;intitation of major phospholipids and neutral lipids using an image ;inalvzer after scpiration by onc-dirncnsion;tl thin-l;iyer clirom;~tog~~phy . clc;wcut sepa- ration was achieved on one EDTA-impregnated chromatoplate with five strp-wise tlevclopments. An acquired, antl integrated optical drnsities individ- rial spots were qiiantit;ited ;I c;imeraqiiipped ana- lyzer against internal standard cholestenl formate....
The aim of the study was to assess fatty acid composition human fertilization-failed oocytes. A total 150 unfertilized oocytes from 43 women undergoing in-vitro fertilization (IVF) were analysed using capillary gas chromatography. majority acids saturated (79.22%), which stearic (38.65%) and palmitic (32.66%) most abundant. Of monounsaturated (14.27%) oleic abundant (9.77%). Polyunsaturated comprised 6.50% acids, n-6:n-3 ratio being 7.73. eicosapentaenoic acid:docosahexaenoic approximately...
Objective: To perform a comprehensive lipid profiling to evaluate potential metabolic differences between patients with amyotrophic lateral sclerosis (ALS) and controls, provide more profound understanding of the abnormalities in ALS. Methods: Twenty ALS 20 healthy controls were enrolled cross-sectional study. Untargeted lipidomics fasting serum samples performed by optimized UPLC-MS platforms for broad lipidome coverage. Datasets analyzed univariate variety multivariate procedures. Results:...
Computer-assisted sperm morphometry analysis has improved the assessment of morphology, but results depend on use adequate evaluation and staining procedures spermatozoa from individual species. In this study, morphological module Sperm Class Analyzer®was used for morphometric stallion heads midpieces. Semen samples were obtained six fertile stallions in order to evaluate influence three (Diff-Quik, Hemacolor Harris' Haematoxylin) accuracy image processing morphometry, effect sample size...
Diverse plants of ethnobotanic interest in Amazonia are commonly used traditional medicine. We determined the antioxidant potential against lipid peroxidation, antimicrobial activity, and polyphenol composition several Amazonian (Brownea rosademonte, Piper glandulosissimum, krukoffii, putumayoense, Solanum grandiflorum, Vismia baccifera). Extracts from plant leaf, bark, stem were prepared as aqueous infusions, folk medicine, added to rat liver microsomes exposed iron. The polyphenolic was...
The characterization of bioactive resveratrol oligomers extracted from Vitis vinifera canes has been recently reported. Here, we screened six these compounds (ampelopsin A, trans-ε-viniferin, hopeaphenol, isohopeaphenol, R2-viniferin, and R-viniferin) for their cytotoxic activity to human hepatocellular carcinoma (HCC) cell lines p53 wild-type HepG2 p53-null Hep3B. efficacy depended on the line. R2-viniferin was most toxic stilbene in HepG2, with inhibitory concentration 50 (IC50) 9.7 ± 0.4...
Abstract: Doxorubicin (DOX), an antineoplastic agent widely used for the treatment of cancer, belongs to anthracycline family antitumor antibiotics. DOX may undergo one‐electron reduction corresponding semiquinone free radical by flavin‐containing reductases. Under aerobic conditions, reacts rapidly with oxygen generate superoxide anion, undergoing redox cycling. At moderate concentrations, reactive species (ROS) play important role as regulatory mediators in signaling processes. We have...
The kind of fat in the diet modifies profile fatty acids brain and also affects aminopeptidase activities tissues. Although modifications acids, neurotransmitters, or enzymes due to dietary composition have been reported, no direct relationship has yet described between specific acid changes neuropeptide metabolism following diet. We investigated lipid some neuropeptidase frontal cortex adult male rats after a period which diets were supplemented with differing their degrees saturation such...
Five fractions of Clematis flammula, a plant widely used in the Mediterranean traditional medicine, were isolated from leaves using selective extraction procedure and their total antioxidant capacity was measured by both ABTS ORAC tests. Furthermore, capacities to inhibit microsomal lipid peroxidation scavenge hydroxyl radical assessed. The cytotoxic potential of crude ethanolic extract aqueous fraction obtained chloroform also evaluated on three human hepatoma cell lines CHL, PLC HuH7....
To assess the modifications of main fatty acids (FA) in plasma and red blood cells during pregnancy.A longitudinal study 36 normal pregnant women was carried out with 3 cut-off points: first trimester, second trimester third trimester. 14 FA erythrocyte phospholipids were measured using capillary gas chromatography. Measurements expressed percentages absolute values.In there a significant increase proportion saturated decrease long chain polyunsaturated (PUFA) both omega 6 (omega 6) 3)...
Abstract: Doxorubicin (DOX) is a potent anticancer drug, whose clinical use limited on account of its toxicity. DOX cytotoxic effects have been associated with reactive oxygen species (ROS) generated during drug metabolism. ROS induce signaling cascades leading to changes in the phosphorylation status target proteins, which are keys for cell survival or apoptosis. The mitogen‐activated protein kinase (MAPK) routes activated response oxidative stress. In this work, cytotoxicity, indicators...