A5086973330- Ovarian function and disorders
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Hormonal and reproductive studies
- Ovarian cancer diagnosis and treatment
- Advanced Glycation End Products research
- Lipid metabolism and disorders
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Phytoestrogen effects and research
- Toxic Organic Pollutants Impact
- Cardiovascular Health and Disease Prevention
- Gestational Diabetes Research and Management
- Endometriosis Research and Treatment
- Pharmacology and Obesity Treatment
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Pregnancy and preeclampsia studies
- Sexual Differentiation and Disorders
- Hypothalamic control of reproductive hormones
- Assisted Reproductive Technology and Twin Pregnancy
- Bone health and osteoporosis research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
National and Kapodistrian University of Athens
2011-2023
Hygeia Hospital
2017-2023
Athens Euroclinic
2015-2017
University of Chile
2017
Athens State University
2000-2016
Athens Medical Center
1996-2016
Sotiria General Hospital
2010-2015
University of Nottingham
2012
Laiko General Hospital of Athens
2000-2010
The University of Texas at Austin
2006
The Androgen Excess Society (AES) charged a task force to review all available data and recommend an evidence-based definition for polycystic ovary syndrome (PCOS), whether already in use or not, guide clinical diagnosis future research.Participants included expert investigators the field.Based on systematic of published peer-reviewed medical literature, by querying MEDLINE databases, we tried identify studies evaluating epidemiology phenotypic aspects PCOS.The drafted initial report,...
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, chronic anovulation, and oligomenorrhea (O/M). PCOS has variable clinical phenotypes, biochemical features, metabolic abnormalities. To determine the prevalence of in Greek population as well parameters, we performed a cross-sectional study 192 women reproductive age (17-45 yr), living on island Lesbos. They were divided into 4 groups according to presence hirsutism (defined Ferriman-Gallwey score > or = 6) O/M: group N...
Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating secretion, insulin resistance developmental exposure androgens are hypothesized play causal role PCOS. Here we map common genetic susceptibility loci European ancestry women for the National Institutes Health PCOS phenotype, which confers...
Bisphenol A (BPA) is a widespread industrial compound used in the synthesis of polycarbonate plastics. In experimental animals, neonatal exposure to BPA results polycystic ovary-like syndrome (PCOS) adulthood. bidirectional interaction between androgens and levels has been disclosed.To determine PCOS women as well association hormonal/metabolic parameters compared control group.Cross-sectional study 71 (National Institutes Health criteria) 100 normal women, age- body mass index-matched,...
Women with polycystic ovary syndrome (PCOS) are insulin resistant secondary to a postbinding defect in signaling. Sequential euglycemic glucose clamp studies at 40 and 400 mU · m −2 min −1 doses serial skeletal muscle biopsies were performed PCOS age-, weight-, ethnicity-matched control women. Steady-state levels did not differ, but insulin-mediated disposal was significantly decreased women ( P < 0.05). Insulin receptor substrate (IRS)-1-associated phosphatidylinositol 3-kinase (PI 3K)...
Evidence suggests that insulin resistance and hyperinsulinaemia are associated with ovarian hyperandrogenism menstrual irregularities in polycystic ovary syndrome (PCOS). Sixteen obese women PCOS on a weight-maintaining diet were studied before after 6 months of therapy the insulin-sensitizing antidiabetic agent metformin at dose 1700 mg per day. Compared baseline values, glucose utilization was markedly enhanced using two-step euglycaemic-hyperinsulinaemic clamp to measure changes...
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, chronic anovulation, and oligomenorrhea (O/M). PCOS has variable clinical phenotypes, biochemical features, metabolic abnormalities. To determine the prevalence of in Greek population as well parameters, we performed a cross-sectional study 192 women reproductive age (17–45 yr), living on island Lesbos. They were divided into 4 groups according to presence hirsutism (defined Ferriman-Gallwey score ≥6) O/M: group N (n =...
Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and related disorders. Elevated serum levels cellular adhesion molecules (CAMs) reflect low-grade chronic inflammation been associated several insulin-resistant states. The objective this study is to investigate whether soluble inflammatory markers [soluble intercellular molecule-1 (sICAM-1), endothelial leukocyte (sE-selectin), vascular cell (sVCAM-1) C-reactive protein (CRP)] are altered in...
Women with polycystic ovary syndrome who present hyperandrogenemia, hyperinsulinemia, and insulin resistance appear to be at high risk of cardiovascular disease. Elevated levels endothelin-1, a marker vasculopathy, have been reported in insulin-resistant subjects endothelial dysfunction. Male gender also seems an aggravating factor for In this study we investigated endothelin-1 women syndrome, evaluated the effect sensitizer, metformin, on levels. Plasma were measured 23 obese (mean age,...
Summary Background The phenotypic spectrum of PCOS has been broadened but the prevalence and clinical significance phenotypes continue to challenge scientific community. Objective Analysis determination association between metabolic, hormonal new ultrasonographic criteria. Design Clinical prospective study. Patients Six hundred thirty‐four women with (18–35 years) comparable body mass index (BMI), diagnosed by ESHRE/ASRM criteria, were categorized into two major groups phenotypes: classic...
The aim of this study was to investigate the endothelial status in young women with polycystic ovary syndrome (PCOS), using a simple and easily reproducible hemodynamic method combined biological marker evaluate effect metformin treatment on these parameters.Descriptive clinical trial.Forty women, 20 PCOS normal similar age body mass index were studied. Metformin (1700 mg daily) administered for 6 months group. endothelium metabolic hormonal profile studied both groups, as well after...
Nonenzymatic advanced glycation and oxidation end-products, end-products (AGEs), impart a potent impact on vessels other tissues in diabetic state euglycaemic conditions with increased oxidative stress. Insulin resistant (IR) polycystic ovary syndrome (PCOS) women, have elevated serum AGEs, receptor (RAGE) expression, deposition differential localization the ovarian tissue (theca granulosa) compared to normal.To determine whether raised AGE levels noninsulin women PCOS is distinct finding...