A5032180952- Ovarian function and disorders
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Advanced Glycation End Products research
- Lipid metabolism and disorders
- Ovarian cancer diagnosis and treatment
- Gestational Diabetes Research and Management
- Cardiovascular Health and Disease Prevention
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy and preeclampsia studies
- Neuroendocrine Tumor Research Advances
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Blood Coagulation and Thrombosis Mechanisms
- Hormonal Regulation and Hypertension
- Pharmacology and Obesity Treatment
- Phytoestrogen effects and research
- Vitamin D Research Studies
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- Alcohol Consumption and Health Effects
- Folate and B Vitamins Research
Hygeia Hospital
2019-2024
European Gravitational Observatory
2024
National and Kapodistrian University of Athens
2007-2021
European University Cyprus
2020-2021
European Institute of Oncology
2020
St Bartholomew's Hospital
2019
Red Cross Hospital
2015-2017
Hellenic Red Cross
2015-2017
Athens State University
2016
Endocrine Society
2016
Bisphenol A (BPA) is a widespread industrial compound used in the synthesis of polycarbonate plastics. In experimental animals, neonatal exposure to BPA results polycystic ovary-like syndrome (PCOS) adulthood. bidirectional interaction between androgens and levels has been disclosed.To determine PCOS women as well association hormonal/metabolic parameters compared control group.Cross-sectional study 71 (National Institutes Health criteria) 100 normal women, age- body mass index-matched,...
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been matter contention. Since 1990 scientific societies in field human reproduction have tried define pivotal criteria for diagnosis PCOS. The consensus Rotterdam included presence hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology (PCOM), now updated evidence based 2018 2023 International Guideline endorsed by...
Nonenzymatic advanced glycation and oxidation end-products, end-products (AGEs), impart a potent impact on vessels other tissues in diabetic state euglycaemic conditions with increased oxidative stress. Insulin resistant (IR) polycystic ovary syndrome (PCOS) women, have elevated serum AGEs, receptor (RAGE) expression, deposition differential localization the ovarian tissue (theca granulosa) compared to normal.To determine whether raised AGE levels noninsulin women PCOS is distinct finding...
The polycystic ovary syndrome (PCOS) and the metabolic (MetS) are common disorders that share many characteristics, particularly abdominal obesity insulin resistance. Our objective was to compare prevalence of MetS between a large cohort patients with PCOS body mass index -matched controls.Cross-sectional study.We studied 1223 277 healthy women. Diagnosis based on revised Rotterdam criteria. Women were divided into those who fulfilled both criteria diagnostic 1990 National Institutes Health...
The levels of advanced glycation end products (AGEs) are increased under conditions impaired glucose metabolism and/or oxidative stress, promoting insulin resistance and other endocrine abnormalities. AGEs play a major role in the pathogenesis several diseases such as diabetes, atherosclerosis, polycystic ovary syndrome Alzheimer's disease, contributing to progressive ageing. Receptor-based clearance by receptor for AGE (RAGE) macrophage scavenger A (SR-A) is considered main factor...
Glyoxalase detoxification system composed of glyoxalase (GLO)-I and GLO-II is ubiquitously expressed implicated in the protection against cellular damage because cytotoxic metabolites such as advanced glycation end products (AGEs). Recently, ovarian tissue has emerged a new target excessive AGE deposition been associated with either high diet experimental animals or hyperandrogenic disorders polycystic syndrome (PCOS) humans. This study was designed to investigate impact dietary AGEs...
Many patients with polycystic ovary syndrome (PCOS) have insulin resistance, obesity (mostly visceral) and glucose intolerance, conditions associated abnormalities in the production of vaspin, a novel adipokine that appears to preserve sensitivity tolerance. The aim study was assess serum vaspin levels PCOS effects on metformin or weight loss. We studied 79 50 healthy female volunteers. Normal (n=25) were treated 850 mg bid for 6 months. Overweight/obese (n=54) prescribed normal-protein,...
Objective Insulin resistance (IR) is frequent in polycystic ovary syndrome (PCOS) and contributes to the increased risk for type 2 diabetes mellitus cardiovascular disease of this population. Several markers IR are used but most expensive or have limited sensitivity specificity. Preliminary data suggest that menstrual cycle pattern correlates with PCOS existing studies small. We aimed assess relationship between irregularities PCOS. Design Prospective study. Methods studied 1285 women PCOS,...
Obesity is frequently present in women with the polycystic ovary syndrome (PCOS) and aggravates insulin resistance (IR) hyperandrogenemia. We aimed to assess effects of orlistat combined lifestyle changes overweight obese PCOS body mass index (BMI)-matched controls.Prospective study.We studied 101 (age 26·1 ± 6·4 years, BMI 34·5 5·9 kg/m(2) ) 29 BMI-matched normal ovulating cycles. All were instructed follow a low-calorie diet exercise treated 120 mg tid for 6 months.Metabolic endocrine...