A5113564595- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Microencapsulation and Drying Processes
- Drug Solubulity and Delivery Systems
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Bee Products Chemical Analysis
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Occupational Health and Safety in Workplaces
- Systemic Lupus Erythematosus Research
- Pneumonia and Respiratory Infections
- Natural Compounds in Disease Treatment
- Intramuscular injections and effects
- Tea Polyphenols and Effects
- Potato Plant Research
- Rheumatoid Arthritis Research and Therapies
- Indoor Air Quality and Microbial Exposure
- Polysaccharides Composition and Applications
- Mass Spectrometry Techniques and Applications
- Food composition and properties
- Fatty Acid Research and Health
- Occupational exposure and asthma
University of Concepción
2014-2024
Institut Galien Paris-Saclay
2006-2008
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2008
Centre National de la Recherche Scientifique
2006-2008
Abstract Bioactive compounds in food and beverages, including fruit juices, are susceptible to degradation or oxidation during processing storage. This vulnerability can lead a reduction nutritional value overall quality of the products. The objective this research is explore potential encapsulation techniques preserving enhancing juices. natural compounds, enzymes, probiotics seen as promising approach fortifying improving their preservation these encapsulated additives packaging. study...
Grape canes, the main byproducts of viticulture industry, contain high-value bioactive phenolic compounds, whose application is limited by their instability and poorly solubility in water. Encapsulation cyclodextrins allows these drawbacks to be overcome. In this work, a grape cane pilot-plant extract (GCPPE) was encapsulated hydroxypropyl beta-cyclodextrin (HP-β-CD) spray-drying technique formation an inclusion complex confirmed microscopy infrared spectroscopy. The profile analyzed...
Abstract: In this work, microparticles were prepared by spray-drying using albumin, chondroitin sulfate, and hyaluronic acid as excipients to create a controlled-release methylprednisolone system for use in inflammatory disorders such arthritis. Scanning electron microscopy demonstrated that these almost spherical, with development of surface wrinkling the load formulation was increased. The also had direct influence on mean diameter zeta potential microparticles. Interactions between active...
Due to their crystalline nature, the encapsulation of hydrophobic corticosteroids within polymeric nanoparticles by o/w solvent evaporation method is often difficult achieve. The aim this study was evaluate effect both process and formulation parameters on a model corticosteroid: methylprednisolone (MP). For purpose, 32factorial design performed evaluating effects concentration emulsifiers sonication time manufactured nanoparticles, followed multiresponse optimization. also included...
Formaldehyde is a chemical compound used as precursor in various industrial processes and hair straightening products. It classified carcinogenic humans. Considering the importance of topic, this review aims to identify characterize health risks that formaldehyde chronic exposure involves describe existing evidence its main toxic effects well risk factors during application process. For purpose, literature was carried out by using PubMed database, limiting it studies conducted between 2010...
Interferons (IFNs) are cytokines involved in the immune response with a synergistic regulatory effect on response. They therapeutics for various viral and proliferative conditions, proven safety efficacy. Their clinical application is challenging due to molecules' size, degradation, pharmacokinetics. We working new drug delivery systems that provide adequate therapeutic concentrations these prolong their half-life circulation, such as nanoformulations.
The aim of the work was to develop rhein loaded polymeric nanoparticles (R-PNPs). Nanoparticles were prepared by three methods, solvent emulsion-evaporation, double emulsion, and nanoprecipitation, means experimental design. Additionally, effects best formulation on in vitro cytotoxicity inflammation evaluated. emulsion-evaporation method presented highest encapsulation efficiency techniques (38.41%), as well had a mean diameter 189.33 nm polydispersity index less than 0.1. Despite efforts...
Rheumatoid arthritis (RA) is an autoimmune chronic disease characterized by disabling pain and deformity of the joints. Teriflunomide (TFM), a metabolite from leflunomide, given orally to RA patients, but its gastrointestinal systemic side effects are severe not well tolerated. This study aims optimize develop nanostructured lipid carriers (NLC) loaded with teriflunomide (NLC-TFM). NLCs were developed homogenization ultrasound. The optimization parameters achieved through Box-Behnken...
Interferons (IFNs) are cytokines involved in the immune response with synergistic regulatory action. They therapeutics for various viral and proliferative conditions, proven safety efficacy. Their clinical application presents difficulties due to molecules' size, degradation, pharmacokinetics. We developed a controlled release system respiratory tract infections. A core-shell nanoparticle was prototyped, which hydrolyzed shell (polyvinylpyrrolidone), releasing active ingredients...
Abstract A new method for the analysis of phospholipids (Lysophosphatidylethanolamine, Phosphatidylethanolamine, Phosphatidylcholine, Sphingomyelin, and Lysophosphatidylcholine) by NP/HILIC-ELSD is described using a silica column. Addition formic acid triethylamine to mobile phase based on acetonitrile/methanol/water delivered isocratically promoted good rapid separation 5 phospholipid classes (15 min run). The use an evaporative light scattering detector allowed direct mixture without...
Despite the availability of drugs and pharmaceutical forms for treatment rheumatoid arthritis osteoarthritis symptoms, their adverse effects lack response to therapy reinforces need search new technological formulation strategies capable delaying progress disease, with better therapeutic results prolonged control arthropathy. The aim this bibliographic review was identify reported approaches these diseases. is an unresolved challenge, due complexity Thus, therapies suppress inflammatory...