A5005238707- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Plant chemical constituents analysis
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Crystallization and Solubility Studies
- Corrosion Behavior and Inhibition
- X-ray Diffraction in Crystallography
- Natural Antidiabetic Agents Studies
- Plant Toxicity and Pharmacological Properties
- Synthesis and Biological Activity
- Chemical synthesis and alkaloids
- Phytochemical compounds biological activities
- Synthesis and biological activity
- Analytical Methods in Pharmaceuticals
- Synthesis and Reactivity of Heterocycles
- Inorganic and Organometallic Chemistry
- Glycosylation and Glycoproteins Research
- Herbal Medicine Research Studies
- Phytochemical Studies and Bioactivities
- Synthesis and pharmacology of benzodiazepine derivatives
- Analytical Chemistry and Chromatography
- Allelopathy and phytotoxic interactions
- Microbial Natural Products and Biosynthesis
Universidad Nacional Autónoma de México
2013-2024
Universidad Autónoma de la Ciudad de México
2021-2024
Rede de Química e Tecnologia
2003-2015
Complexo Hospitalario Universitario A Coruña
2008
The α-glucosidase inhibitory activity of an aqueous extract and compounds from the aerial parts V. corymbosa was demonstrated with yeast rat small intestinal α-glucosidases. inhibited a half maximal concentration (IC50) 28.6 μg/mL. Bioassay-guided fractionation led to isolation several compounds, including one cyanogenic glycoside [prunasin (1)], five flavonoids [(-)-epi-catechin (2), hyperoside (3), isoquercetin (4), quercitrin (5) quercetin-3-O-(6''-benzoyl)-β-galactoside (6)] two simple...
The CH2Cl2−MeOH (1:1) extract of the leaves Hintonia standleyana and H. latiflora caused significant decrease in blood glucose levels both normal streptozotozin (STZ)-induced diabetic rats when compared with vehicle-treated groups (p < 0.05). These extracts were not toxic to mice according Lorke criteria. From hypoglycemic standleyana, two new 4-phenylcoumarins, namely, 6′′-O-acetyl-5-O-β-d-galactopyranosyl-7,4′-dihydroxy-4-phenylcoumarin (1)...
From an extract prepared from the grain-based culture of Malbranchea flavorosea two new polyketides, namely, 8-chloroxylarinol A (1) and flavoroseoside (2), along with known compounds xylarinol (3), B (4), massarigenins C (5 6), clavatol (7), were isolated. The structures 1 2 elucidated using spectroscopic methods corroborated by single-crystal X-ray diffraction analysis. In case compound absolute configuration at stereogenic centers was established according to method Flack. addition,...
An infusion prepared from the aerial parts of Salvia amarissima Ortega inhibited enzyme protein tyrosine phosphatase 1B (PTP-1B) (IC50~88 and 33 μg/mL, respectively). Phytochemical analysis yielded amarisolide (1), 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (2), 6-hydroxyluteolin (3), rutin (4), rosmarinic acid (5), isoquercitrin (6), pedalitin (7) a new neo-clerodane type diterpenoid glucoside, named G (8a,b). Compound 8a,b is natural product, 2–6 are reported for first time species. All...
In order to assess whether or not the Arg-276 of CTX-M-type enzymes is equivalent Arg-244 IRT-TEM-derivative enzymes, we replaced former with six different amino acids, some them previously described as involved in resistance β-lactamase inhibitors TEM-IRT derivatives. We also investigated role Arg276 cefotaxime hydrolysis. By site-directed mutagenesis and by use blaCTX-M-1 gene template, was acids (Trp, His, Cys, Asn, Gly Ser). MICs β-lactams alone combination were established. The seven...
Abstract Objectives The aims of this study were to establish the antimicrobial potential Hofmeisteria schaffneri essential oil and its chemical composition. Methods oils harvested at flowering (batches I IV) non-flowering II III) seasons prepared by hydrodistillation analysed GC GC-MS. aqueous organic (CH2Cl2-MeOH 1 : 1) extracts using infusion maceration techniques, respectively. in-vitro activity preparations compounds against Candida albicans some bacteria (Gram-negative Gram-positive)...
Demethylisoencecalin (1) and caleins A (4) C (5) (3.16-31.6 mg/kg, p.o.), the major components from an infusion of Calea ternifolia controlled postprandial glucose levels during oral sucrose tolerance test (OSTT, 3 g/kg) in normal nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) hyperglicemic mice. The effects were comparable to those acarbose (5 mg/kg). During isolation 1, 4, 5, four additional metabolites not previously reported for plant, obtained, namely...
The ability of yeast cells Histoplasma capsulatum to attach and agglutinate human erythrocytes has been described. This is the first report involving these yeasts in hemagglutination phenomenon. Results revealed that were able bind irrespective blood groups them when a high density was used. Assays on inhibition attachment also performed, using sugar-treated cells. indicate galactose (Gal), mainly beta-anomer, specially inhibited attachment. Disaccharides (Gal-derivatives) glycosaminoglycans...
Fractionation of an aqueous extract from the aerial parts Ageratina grandifolia yielded a new natural product, namely, 4-hydroxy-3-((S)-1′-angeloyloxy-(R)-2′,3′-epoxy-3′-methyl)butylacetophenone (1), along with eight known compounds, including three flavonoids (2–4) and five chromenes (5–9). NMR data interpretation DFT-calculated chemical shifts combined DP4+ statistical J-DP4 probability analyses allowed for complete characterization compound 1. The presence 1 in plant that biosynthesizes...
Activity-directed fractionation of a CH2Cl2−MeOH (1:1) extract Hofmeisteria schaffneri led to the isolation new phytotoxin characterized as 2'-(2' '-hydroxy-4' '-methylphenyl)-2'-oxoethyl acetate and designated trivial name hofmeisterin (1). In addition, known compounds β-carotene, euparin, 3',4',4a',9a'-tetrahydro-6,7'-dimethylspiro[benzofuran-3(2H),2'-pyrano[2,3-b]benzofuran]-2,4a'-diol (2) were obtained. The identification isolates was accomplished by spectroscopic methods. structure 1...
Potential toxic effects in mice of an infusion prepared from the stem bark Exostema caribaeum was assessed by means Lorke procedure. The preparation not found to be toxic, with LD50 value estimated more than 5 g/kg. This at 100, 300, and 500 mg/kg also caused a significant hypoglycemic effect reduction postprandial glycemia peak both normal nicotinamide/streptozotocin (NA/STZ)-diabetic oral sucrose tolerance test. Phytochemical analysis revealed that major active principles are...
An aqueous extract prepared from the aerial parts of Zinnia grandiflora was found not to induce acute toxicity (LD50> 5g/kg, p.o.) in mice when tested by Lorke method. This showed notable antinociceptive and anti-inflammatory actions evaluated formalin- (ED50 = 224.62 ± 38.17 mg/kg, carrageenan-induced paw edema models mice, respectively. The organic-soluble fractions obtained partitioning infusion with CH2Cl2 EtOAc were also active formalin test. most important effect observed fraction;...
Artemisia ludoviciana Nutt. (Asteraceae) is widely used in Mexican folk medicine for treating inflammation, diabetes and painful complaints. The vivo antinociceptive, antiinflammatory antihyperalgesic activities of an aqueous extract (AE) the plant were investigated using well-known animal models. AE reduced licking time formalin test healthy NA-STZ mice; activity was better during inflammatory phase; accordingly, it displayed significant when tested at same doses carrageenan-induced oedema...
This work aimed to discover protein tyrosine phosphatase 1B (PTP1B) inhibitors from a small molecule library of natural products (NPs) derived selected Mexican medicinal plants and fungi find new hits for developing antidiabetic drugs. The showing similar IC50 values ursolic acid (UA) (positive control, = 26.5) were considered hits. These compounds canophyllol (1), 5-O-(β-D-glucopyranosyl)-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin (2), 3,4-dimethoxy-2,5-phenanthrenediol (3), masticadienonic...