A5070952197- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Parvovirus B19 Infection Studies
- Erythrocyte Function and Pathophysiology
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Blood donation and transfusion practices
- Viral-associated cancers and disorders
- Prenatal Screening and Diagnostics
- Child Nutrition and Water Access
- Chronic Lymphocytic Leukemia Research
- Global Maternal and Child Health
- Metabolism and Genetic Disorders
- Food Science and Nutritional Studies
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Blood disorders and treatments
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Plant Micronutrient Interactions and Effects
- Tissue Engineering and Regenerative Medicine
- Cutaneous lymphoproliferative disorders research
Mahidol University
2015-2024
Siriraj Hospital
2014-2023
MRC Weatherall Institute of Molecular Medicine
2008
Human genetic variation has enabled the identification of several key regulators fetal-to-adult hemoglobin switching, including BCL11A, resulting in therapeutic advances. However, despite progress made, limited further insights have been obtained to provide a fuller accounting how contributes global mechanisms fetal (HbF) gene regulation. Here, we conducted multi-ancestry genome-wide association study 28,279 individuals from cohorts spanning 5 continents define architecture human impacting...
Severe forms of α-thalassaemia, haemoglobin H disease and Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity burden α-thalassaemia region remains limited. We compiled a geodatabase prevalence surveys and, using geostatistical modelling methods, generated first continuous maps mutations Thailand sub-national estimates number newborns with severe 2020. also summarised current evidence-base for region. estimate...
Alpha thalassemia major (ATM) is a hemoglobinopathy that usually results in perinatal demise if utero transfusions (IUTs) are not performed. We established an international registry (NCT04872179) to evaluate the impact of IUTs on survival discharge (primary outcome) as well and neurodevelopmental secondary outcomes. Forty-nine patients were diagnosed prenatally, 11 postnatally, all spontaneous survivor genotypes had preserved embryonic zeta-globin levels. compared 3 groups patients; group 1,...
Abstract Recently, complications in patients with nontransfusion‐dependent thalassemia (NTDT), particular those β‐thalassemia intermedia (β‐TI), were found to be significantly different from transfusion dependent (TDT), mainly major (β–TM). However, this information is rather limited other forms of NTDT. In prospective study, adult Thai NTDT interviewed and clinically evaluated for related complications. Fifty‐seven (age 18‐74 years), 59.6% Hb E/β‐thalassemia 40.4% H disease, recruited;...
Alpha thalassemia is the most common genetic disease in world with prevalence of carriers ranging from 5-50% several populations. Coinheritance two defective α-globin genes usually gives rise to a symptomatic condition, hemoglobin (Hb) H disease. Previously, it has been suggested studies different populations that nondeletional Hb (--/αTα or --/ααT) generally more severe than deletional type (--/-α). In this report, we describe four rare α-thalassemia mutations Thai individuals, including...
Event free survival at 24 months (EFS24) has been described as a powerful predictor for outcome in several subtypes of B cell lymphoma. However, it was limitedly T We explored the implication EFS24 marker peripheral lymphoma (PTCL). reviewed 293 systemic PTCL patients 13 nationwide major university hospitals Thailand from 2007 to 2014. The median event (EFS) and overall (OS) our cohort 16.3 27.7 with corresponding 2-year EFS OS 45.8% 51.9%, respectively. A total 118 achieved (no events...
Abstract Background Thalassemia is a common inherited hemoglobin disorder in Southeast Asia. Severe thalassemia can lead to significant morbidity for patients and economic strain under-resourced health systems. Thailand’s prevention control program has successfully utilized prenatal screening diagnosis reduce the incidence of severe Thai populations, but migrant populations are excluded despite having high prevalence. We sought identify key barriers facilitators develop tailored...
Background and Objectives . To explore the role of cis -regulatory sequences within β globin gene cluster at chromosome 11 on human γ expression related to Hb E allele, we analyze baseline hematological data F values together with haplotypes in homozygous E. Patients Methods 80 individuals molecularly confirmed were analyzed for Xmn I polymorphism using PCR-RFLPs. 74 complete laboratory further studied association analyses. Results Eight different found linked alleles; three major (a) (III),...
Abstract Background Thalassemia, an inherited hemoglobin disorder, has become a global public health problem due to population migration. Evidence-based strategies for thalassemia prevention in migrants are lacking. We characterized barriers screening and the burden of migrant workers Thailand. Methods Multilingual demographic KAP surveys were completed by 197 Thai, 119 Myanmar, 176 Cambodian adults residing Thalassemia awareness, socio-demographic predictors, knowledge attitude scores...
Objectives: There are more than 200 known mutations found in patients with β-thalassemia, a possibility to identify an unknown or novel mutation becomes less possible. Here, we report patient from Thailand who presented chronic hemolytic anemia.Methods: A comprehensive hematology and DNA analysis was applied the index her mother.Results: Hematological hemoglobin analyses were consistent clinical diagnosis of Hb E/β0-thalassemia. However, could find only E heterozygous using our common...
Abstract Based on Thalassemia International Federation clinical practice guidelines (CPG) for non-transfusion dependent and transfusion thalassemia, several measures should be routinely implemented such as monitoring surveillance of thalassemia related complications early detection proper management. To evaluate the prevalence performance routine during 2 periods; before after published CPGs (2012–2014 vs 2015–2017), data from 524 adult patients attended at Siriraj hospital were compared...
There are few stem cells in human peripheral blood (PB). Increasing the population and plasticity of PB applying it to regenerative medicine require suitable culture methods. In this study, leukocyte populations 250 mL were collected using a separator before that cultured optimal cell medium for 4 7 days. After culturing, stemness characteristics analyzed, red removed from cells. our results, markers Sca-1 + CD45 , CD117 very small embryonic-like CD34 Lin − CXCR4 significantly increased....