A5102962816- Protein Tyrosine Phosphatases
- Ubiquitin and proteasome pathways
- Protein Kinase Regulation and GTPase Signaling
- Biochemical and Molecular Research
- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Mechanisms of cancer metastasis
- Pharmaceutical Practices and Patient Outcomes
- Breast Cancer Treatment Studies
- Psoriasis: Treatment and Pathogenesis
- Cancer Research and Treatments
- Traditional Chinese Medicine Studies
- Cancer, Lipids, and Metabolism
- Epilepsy research and treatment
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Pregnancy and preeclampsia studies
- Advanced Breast Cancer Therapies
- Pharmacological Effects of Natural Compounds
Nanjing University of Chinese Medicine
2021-2022
Jiangsu Province Hospital
2021-2022
Nanjing Medical University
2022
Jiangsu University
2022
Second Affiliated Hospital of Nanjing Medical University
2022
Tris Pharma (United States)
2022
Novartis (United States)
2022
China Pharmaceutical University
2012
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor GDP-bound that forms novel interactions with the switch II pocket. potently inhibits KRASG12C-driven cellular signaling demonstrates selective antiproliferative in cell lines, including those G12C/H95 double mutations. In vivo, induces AUC...
3005 Background: SHP2 transduces signals from activated receptor tyrosine kinases to downstream pathways including MAPK. TNO155 is a selective, allosteric, oral inhibitor of SHP2. Methods: CTNO155X2101 (NCT03114319) an ongoing first-in-human, open-label dose escalation/expansion trial in adults with advanced solid tumors. The primary objective characterize the safety and tolerability identify regimen(s) for future study. Secondary assessments included pharmacokinetics, pharmacodynamics,...
Abstract Background: KRAS G12C oncogenic mutations occur in ~13% of non-small cell lung cancers (NSCLCs) and up to 4% other solid tumors. JDQ443 is a selective, covalent, orally bioavailable, investigational KRASG12C inhibitor that irreversibly traps the inactive, GDP-bound state. structurally unique forms novel interactions with switch II pocket. Methods: KontRASt-01 (NCT04699188) Phase Ib/II, open-label, multicenter, dose-escalation dose-expansion trial as monotherapy or combination TNO155...
Inflammation is an important contributor to autoimmune thyroiditis. Yanghe decoction (YH) a traditional Chinese herbal formulation which has various anti-inflammatory effects. It been used for the treatment of diseases such as ankylosing spondylitis In this study we aimed investigate effects YH on thyroiditis in rat model and elucidate underlying mechanisms. The experimental (EAT) was established by thyroglobulin (pTG) injections excessive iodine intake. Thyroid lesions were observed using...
Red blood cell distribution width (RDW) is an important parameter with broad biological implications. However, the study investigating association between RDW and thyroid function remains sparse inconsistent. We aimed to investigate in US population.A cross-sectional analysis was performed using data from National Health Nutrition Examination Survey (NHANES) conducted 2007 2010. The parameters investigated were mainly free triiodothyronine (fT3), thyroxine (fT4), thyroid-stimulating hormone...
The objective of this study was to investigate the safety and pharmacokinetics edaravone administered by single or successive intravenous infusions in healthy Chinese volunteers. A total 30 subjects (15 males 15 females) were recruited randomly assigned three groups receiving doses 20, 30, 60 mg. All received a dose during 30-minute period, only mg group continued receive same successively infusion twice daily for next 5 days. Plasma concentrations monitored high-performance liquid...
Aim Emerging evidence indicates that palmitic acid (PA) can regulate the progression and development of many diseases. However, studies examining association between PA thyroid function remain sparse. We aimed to investigate serum (sPA) in US population. Methods In this retrospective study, a cross-sectional analysis was performed using data pooled from database National Health Nutrition Examination Survey (NHANES) 2011 2012. The parameters investigated were mainly free triiodothyronine...
Background. Yanghe decoction is a famous formula consisting of Rehmannia, deer horn gum, cinnamon, rue, Ephedra, ginger charcoal, and licorice. However, few studies have explored the role potential mechanism in treatment Hashimoto’s thyroiditis by metabolomics. Methods. Nine mice were randomly divided into three groups: control group (group C), model M), drug administration T), with each group. Mice groups M T established as models thyroiditis, was treated decoction. The metabolome plasma...
Abstract Background Kirsten rat sarcoma virus (KRAS) is a GTPase that regulates cell signaling pathways involved in proliferation, survival, and tumorigenesis. Somatic mutations KRAS resulting glycine to cysteine substitution at codon 12 (KRAS G12C) lead shift toward active, GTP-bound increased oncogenic signaling. G12C occur approximately 13% of non-squamous, non-small lung cancer (NSCLC) cases, lower frequencies other solid tumor malignancies. JDQ443 (NVP-JDQ443) selective, covalent,...
Abstract Background: Triple-negative breast cancer (TNBC) is a relatively rare subtype of cancer, and prone to lymph node metastasis at early stage. However, there lack prognosis prediction models. The purpose this study develop validate an effective nomogram for predicting the probability in early-stage TNBC. Methods : We selected 26,775 eligible patients who were diagnosed with TNBC between 2010 2015 from Surveillance, Epidemiology, End Results database. All randomly divided into training...
Background: Triple-negative breast cancer (TNBC) is an aggressive type of associated with poor prognosis and limited treatment options. The androgen receptor (AR) has emerged as a potential therapeutic target for Luminal AR (LAR) TNBC. However, multiple studies have claimed that anti-androgen therapy AR-positive TNBC only clinical benefits.Methods: Immunohistochemistry tissue sections were applied investigating expression in tissues. In vitro vivo assays used exploring the function during...