A5101410136- interferon and immune responses
- Immune Response and Inflammation
- Salmonella and Campylobacter epidemiology
- Autophagy in Disease and Therapy
- Ruminant Nutrition and Digestive Physiology
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- RNA modifications and cancer
- Gut microbiota and health
- Computational Drug Discovery Methods
- Bacterial Genetics and Biotechnology
- Gout, Hyperuricemia, Uric Acid
- Protein Structure and Dynamics
- Escherichia coli research studies
- CRISPR and Genetic Engineering
- Cellular transport and secretion
- Agricultural Systems and Practices
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Immune cells in cancer
- Machine Learning in Bioinformatics
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Animal Nutrition and Physiology
Hengyang Academy of Agricultural Sciences
2025
Hospital for Sick Children
2021-2025
Northeast Forestry University
2022
Lanzhou University
2018
Wuhan University
2013-2017
Zhejiang University
2001
Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection
Recognition of viral double-stranded RNA by Toll-like receptor 3 (TLR3) triggers activation the transcription factors NF-κB and interferon regulated factor 3, leading to induction type I interferons proinflammatory cytokines. TIR-domain–containing adapter-inducing interferon-β (TRIF) is an adapter protein required for TLR3-mediated signaling. Here we identified E3 ubiquitin ligase WW domain-containing 2 (WWP2) as a TRIF-associated biochemical purification. WWP2 mediated K48-linked...
Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to induction interferons (IFNs) and proinflammatory cytokines, innate antiviral response. Here we identified the RNA-binding protein Mex3B as a positive regulator TLR3-mediated signaling expression cloning screens. Cells from Mex3b(-/-) mice exhibited reduced production IFN-β in response analog poly(I:C) but not infection with RNA viruses. injected was more resistant poly(I:C)-induced death. associated TLR3 endosomes. It bound...
Abstract This research demonstrates that DCC-2036 (Rebastinib), a potent third-generation tyrosine kinase inhibitor (TKI), effectively suppresses tumor growth in colorectal cancer (CRC) models with functional immune systems. The findings underscore the capacity of to enhance both activation and cytotoxic functionality CD8 + T cells, which are crucial for facilitating anti-tumor responses. Through comprehensive multi-omics investigations, significant shifts gene protein expression profiles...
Salmonella utilizes type 3 secreted effector proteins to induce plasma membrane (PM) perturbations during invasion of host cells1. The effectors drive mobilization membranes generate cell surface ruffles, followed by invagination and scission the PM Salmonella-containing vacuoles (SCVs)2. Here, we show that LRRK2 kinase generates reservoirs exploited invasion. are tubular compartments associated with under basal conditions formed through phosphorylation RAB10 GTPase LRRK2. Mobilization...
Depolarized mitochondria can be degraded via mitophagy, a selective form of autophagy. The RAB GTPase RAB7A was recently shown to play key role in this process. regulates late endocytic trafficking under normal growth conditions but is translocated the mitochondrial surface following depolarization. However, how activity regulated during mitophagy not understood. Here, using proximity-dependent biotinylation approach (miniTurbo), we identified C5orf51 as specific interactor GDP-locked RAB7A....
Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated the central adaptor VISA. How RIG-I-VISA-mediated response terminated at late phase infection enigmatic. Here we identified protein kinase A catalytic (PKAC) subunits α and β as negative regulators virus-triggered signaling in a redundant manner. Viral up-regulated cellular cAMP levels activated PKACs, then phosphorylated VISA T54. This phosphorylation abrogated virus-induced aggregation...
Prediction of protein secondary structures is an important problem in bioinformatics and has many applications. Successful structure predictions provide a starting point for direct tertiary modelling, also can significantly improve sequence analysis sequence-structure threading aiding function determination. Now prediction methods routinely achieve accuracy (Q3) about 70%. We believe this could be further improved by using hybrid method as essential part the process. In article, SVM(HSVM)...