Background: Extracorporeal membrane oxygenation (ECMO) is increasingly used in patients undergoing complex thoracic surgical procedures. However, studies reporting the clinical outcomes of these are limited to case reports, without real consensus. Our aim was evaluate perioperative use ECMO as respiratory and/or circulatory support surgery: indications, benefits, and management. Methods: Between May 2013 December 2018, we reviewed data 15 (11 males 4 females; mean age: 47 years old; range,...

Refractory septic shock is a serious disorder with high mortality. There currently limited evidence to support the use of extracorporeal membrane oxygenation (ECMO) in adult shock. We describe outcome patients refractory our hospital and try identify prognostic factors.We studied total 23 (14 males 9 females) treated venoarterial (VA) ECMO hospital. Clinical parameters survival death groups, laboratory before after placement were analyzed.Eight successfully weaned off five discharged. The...

The real-world usage of intra-aortic balloon pump (IABP) in various cardiogenic shocks (CS) and the association with outcomes are lacking. We aimed to investigate IABP adoption CS a nationwide registry China.We retrospectively retrieved data 30 106 patients (age 67.1 ± 14.6 years, 37.6% female patients) Hospital Quality Monitoring System from 2013 2016. Ischaemic heart disease was leading cause (73.9%). Hypertension, cardiomyopathy, myocarditis, valvular, congenital were seen 36.0%, 7.5%,...

The gaps between the blades and shroud (or hub) of an axial blood pump affect hydraulics, efficiency, hemolytic performance. These are critical parameters when a is manufactured. To evaluate influence blade on performance, flow characteristics inside with different radial were numerically simulated analyzed special attention paid to hydraulic characteristics, gap flow, hemolysis index (HI). In vitro testing particle image velocimetry conducted verify numerical results. simulation results...

Cardiac surgery-associated acute kidney injury (CS-AKI) occurs in up to 40%~60% of paediatric patients and increases postoperative morbidity mortality. A goal-directed perfusion (GDP) strategy aimed at maintaining indexed oxygen delivery (DO2i) above the critical threshold (reported be 260~300 mL/min/m2 adults) during cardiopulmonary bypass (CPB), is effective reducing incidence CS-AKI. However, no clear standards DO2i exist. Our prior prospective cohort study exploring CPB has found nadir...

The tip structure of LVAD inflow cannula is one major factors to lead adverse events such as thrombosis and suction leading obstruction. In this research, four kinds tips that had been used in cannulas were selected designed. flow field the inserted into apex left ventricle (LV) was numerically computed by computational fluid dynamics. behavior analyzed order compare blood compatibility after with different LV. results showed affected performance. Among these cannulas, trumpet-tipped owned...

Background Hyperlactatemia (HL) during cardiopulmonary bypass (CPB) is relatively frequent in infants and associates with increased morbidity mortality. Studies on adults have shown that carbon dioxide production index (VCO 2 i) CPB linked to the occurrence of HL, ‘critical thresholds’ for VCO i reported be 60 mL/min/m . However, considering a higher metabolic rate lower tolerance hypoxia, critical threshold cannot replied existing adults’ standards. The objective this study investigate...

A fully implantable axial left ventricular assist device LAP31 was developed for Chinese or other heart failure patients who need partial support. Based on the 5-Lpm total cardiac blood output of without disease, design point set to a flow rate 3 Lpm with 100-mmHg pressure head. To achieve required head and good hemolytic performance, structure that includes spindly rotor hub diffuser splitter cantilevered main blades developed. Computational fluid dynamics (CFD) used analyze hydraulic...

Device thrombosis inside ventricular assist devices remains a limitation to their long-term clinical use. Thrombosis potential exists in almost all because the device-induced high shear stress and vortices can activate platelets, which then aggregate adhere surfaces device. To decrease device of use devices, methodology entitled platelet adhesion emulation for predicting position is developed. The combines numerical simulations with vitro experiments by correlating structure flow passage...

Background Mechanical ventricular assistance is an important therapeutic method for severe heart failure patients. A variety of assist devices have been designed use. The purpose this report was to describe the experience using Abiomed BVS5000 as a means left support clinical treatment Methods From February 2004 April 2006, 12 male patients were supported with device (LVAD) at Fu Wai Hospital. average age (55.2±9.6) years (range 39 68 years). mean body surface area (1.76±0.1) m2 1.6 1.9 m2)....

A fully implantable, axial flow blood pump has been developed in Fu Wai Hospital aiming for clinical use. This ventricular assist device (VAD), which was after numerous CFD analyses the characteristics of pump, is 58.5-mm long, 30-mm wide (including DC motor), and weighs 240 g. The can deliver 5 L/min pressures 100 mm Hg over 8,000 rpm. In this study, short-term hemocompatibility effects left (LVAD) (FW pump) were evaluated four healthy sheep. implanted into apex beating hearts. outflow...

We investigated the outcome of FW-II axial pump on healthy sheep (weight, 60-70 kg) for 2 weeks by perioperatively hematological and chemical tests, circulating activated platelet leukocyte-platelet aggregates measurements flow cytometry assays. Complete necropsy histopathological examinations thorough inspection were performed at study termination evidence thrombi. In this experimental series, one died pulmonary edema, other four reached scheduled endpoint 14 days without device-related...

Abstract Pump thrombosis potential exists in most blood pumps and limits their clinical use. To improve the pump performance of pumps, a method for emulating platelet deposition on flow passage component surfaces inside was presented tested. The emulates deposition, employing laser‐induced fluorescence tracing technology. rotated mock circulation loop with deionized water filled fluorescent particles. were then explored via laser. particles induced by laser imaged charge‐coupled device (CCD)...

Abstract Background and aims To explore the biological variation (BV) of kidney injury markers in serum urine healthy subjects within 24 hours to assist with interpretation future studies using these biomarkers context known BV. Materials methods Serum samples were collected every 4 (0, 4, 8, 12, 16 20 hours) from 31 creatinine (s-Crea), β2-microglobin (s-β2MG), cystatin C (s-CYSC), neutrophil gelatinase-associated lipoprotein (s-NGAL), (u-Crea), (u-β2MG), (u-CYSC), (u-NGAL) measured....

BACKGROUND:Cannula shape and connection style influence the risk of thrombus formation in blood pump by varying flow characteristics inside pump. Inlet cannulas should be designed based on need for anatomical fit reducing generation The effects cone-shaped bend inlet axial pumps studied. MATERIAL AND METHODS:The were as cone-shaped, with 1 bent section connecting 2 straight sections. Both silicone tube novel cannula simulated comparison. fields a computational fluid dynamics (CFD) at flows...

<title>Abstract</title> Background Adrenoleukodystrophy (ALD) is a rare X-linked neurogenetic disease caused by mutations in the <italic>ABCD1</italic> gene. Currently, molecular mechanisms underlying onset and severity of ALD still remain unclear. Therefore, aim this paper to mine information on candidate genes associated with transcriptome sequencing whole blood samples from monozygotic twin families disease. Method The identifying differentially expressed (DEGs), set theory analysis, gene...

<title>Abstract</title> Adrenoleukodystrophy (ALD) is a rare X-linked neurogenetic disease caused by mutations in the <italic>ABCD1</italic> gene. Currently, molecular mechanisms underlying onset and severity of ALD still remain unclear. Therefore, aim this paper to mine information on candidate genes associated with transcriptome sequencing whole blood samples from monozygotic twin families disease.<bold> </bold>The identifying differentially expressed (DEGs), set theory analysis, gene...

Sevoflurane presents reliable central neuromuscular effects. However, little knowledge is available regarding the interaction between sevoflurane and demedetomidine. We evaluated effect of dexmedetomidine on in patients with normal transmission calculated 50% effective concentration (EC50).One-hundred forty-four ASA grade I~II transmission, aged 20~60 years old, undergoing lower limbs surgery were enrolled this open-label, dose-escalation clinical trial. Patients randomly assigned into 12...