A5083461976- Ultrasound in Clinical Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Arrest and Resuscitation
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Cardiac and Coronary Surgery Techniques
- Extracellular vesicles in disease
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Radiology practices and education
- Gastrointestinal motility and disorders
- Sepsis Diagnosis and Treatment
- Enhanced Recovery After Surgery
- High Altitude and Hypoxia
- Diabetes Management and Research
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Eicosanoids and Hypertension Pharmacology
Medical University of Vienna
2011-2024
The pulmonary endothelium is an immediate recipient of high oxygen concentrations upon therapy and mediates down-stream responses. Cyclic collapse reopening atelectatic lung areas during mechanical ventilation with fractions inspired result in the propagation oscillations hypoxic/hyperoxic range. We used primary murine endothelial cell cultures to investigate responses constant oscillating conditions hypoxic hyperoxic Severe hyperoxia had pro-inflammatory cytotoxic effects including increase...
The lung can experience different oxygen concentrations, low as in hypoxia, high under supplemental therapy, or oscillating during intermittent hypoxia obstructive sleep apnea hypoxia/hyperoxia due to cyclic atelectasis the ventilated patient. This study aimed characterize oxygen-condition-specific protein composition of extracellular vesicles (EVs) released from human pulmonary microvascular endothelial cells vitro decipher their potential role biotrauma using quantitative proteomics with...
ABSTRACT Background: Supplemental oxygen is administered routinely in the clinical setting to relieve or prevent tissue hypoxia, but excessive exposure may induce oxidative damage disrupt essential homeostatic functions. It speculated that stress leukocytes and platelets contribute vascular diseases by promoting inflammation cell aggregation. Methods: In this pilot study 30 healthy male volunteers (18–65 years) were exposed high concentration (non-rebreather mask, 8 L/min, 100% O 2 )...
Abstract Introduction Due to the technical progress point-of-care ultrasound (POCUS) is increasingly used in critical care medicine. However, optimal training strategies and support for novices have not been thoroughly researched so far. Eye-tracking, which offers insights into gaze behavior of experts may be a useful tool better understanding. The aim this study was investigate feasibility usability eye-tracking during echocardiography as well analyze differences patterns between...
Current resuscitation guidelines recommend that skilled persons could use ultrasound to detect reversible causes during cardiopulmonary (CPR) where the examination can be safely integrated into Advanced Life Support (ALS) algorithm. However, in a prehospital setting performing and rapidly interpreting challenging for physicians. Implementing remote, expert-guided, real-time transmissions of examinations offers opportunity tele-support, even an out-of-hospital cardiac arrest (OHCA). The aim...
Supplemental oxygen is frequently used together with mechanical ventilation to achieve sufficient blood oxygenation. Despite the undoubted benefits, it vigorously debated whether too much can also have unpredicted side-effects. Uncertainty due fact that molecular mechanisms are still insufficiently understood. The lung endothelium covered an exceptionally broad glycocalyx, carrying N- and O-glycans, proteoglycans, glycolipids glycosaminoglycans. Glycan structures not genetically determined...
Oxygen conditions in the lung determine downstream organ functionality by setting partial pressure of oxygen, regulating redox homeostasis and activating mediators that can be propagated blood stream. Examples for such are secreted soluble or vesicle-bound molecules (proteins nucleic acids) taken up remote target cells impacting their metabolism signaling pathways. MicroRNAs (miRNAs) have gained significant interest as intercellular communicators, biomarkers therapeutic targets this context....