A5003358953- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Poverty, Education, and Child Welfare
- Mobile Health and mHealth Applications
- Adolescent and Pediatric Healthcare
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Ethics in Clinical Research
- Maternal Mental Health During Pregnancy and Postpartum
- Global Maternal and Child Health
- HIV/AIDS Impact and Responses
- ICT in Developing Communities
- Child Nutrition and Water Access
- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Biomedical Ethics and Regulation
- Migration, Health and Trauma
- Acute Lymphoblastic Leukemia research
- Homelessness and Social Issues
- T-cell and Retrovirus Studies
AMPATH
2016-2025
Moi University
2006-2016
Stigma shapes all aspects of HIV prevention and treatment, yet there are limited data on how HIV-infected youth their families affected by stigma in sub-Saharan Africa. The authors conducted a qualitative study using focus group discussions among 39 adolescents receiving care at clinics western Kenya 53 caregivers children. Participants felt that while knowledge access to treatment were increasing, many community members still held negative inaccurate views about HIV, including associating...
Mobile technologies represent potentially novel and scalable intervention delivery platforms for adolescents living with HIV (ALWH) in low- middle-income countries. We conducted a prospective, mixed methods pilot study to evaluate the acceptability feasibility of WhatsApp® platform deliver individual counseling services facilitate peer support ALWH western Kenya. Thirty (17 female, mean age 15.4) on ART, engaged care aware their status, were enrolled. After 6 months, participants described...
Abstract Introduction There are approximately 1.7 million adolescents living with HIV (ALHIV, ages 10 to 19) globally, including 110,000 in Kenya. While ALHIV experience poor retention care, limited data exist on factors underlying disengagement. We investigated the burden of trauma among disengaged western Kenya, and its potential role care Methods performed in‐depth qualitative interviews who had from at two sites, their caregivers healthcare workers (HCW) 2018 2020. Disengagement was...
Introduction Adolescents living with HIV (ALHIV, ages 10–19) experience complex challenges to adhere antiretroviral therapy (ART) and remain in care, may be vulnerable wide-scale disruptions during the COVID-19 pandemic. We assessed for a range of effects pandemic on ALHIV western Kenya, whether were greater recent histories being lost program (LTP). Methods recruited from an ongoing prospective study at 3 sites Kenya. The parent enrolled participants February 2019–September 2020, into...
Introduction: Mobile technologies represent a scalable platform for delivering knowledge and interventions targeting adolescents living with HIV (ALWH) in low middle income countries. Data from mobile can be used to assess the contextual understanding experiences of ALWH. Methods: We examined HIV-related knowledge, attitudes, beliefs, behaviors, Kenyan ALWH revealed data enrollment WhatsApp® group chat intervention. Results: Thirty (17 female, mean age 15.4) on ART, engaged care aware their...
Half a million women die annually from pregnancy related causes. In Kenya, maternal mortality ratio (MMR) remains high in spite of great efforts to improve health care. We studied some factors linked maternity rural community setting. A survey was conducted the living Madiany division Siaya County, Kenya. randomly sampled 403 mothers children under three years old. Variables interest were antenatal care attendance (ANC), parity, distance facility and empowerment (autonomy). Nearly 94% had at...
We evaluated the impact of a patient-centred, culturally and age-appropriate disclosure counselling intervention on HIV rates among Kenyan children living with HIV. A prospective, clinic-cluster randomized trial. followed 285 child-caregiver dyads (children ages 10-14 years) attending eight clinics (randomized to or control) in Kenya. Participants at received intensive trained counsellors tailored materials, compared control standard care. Disclosure was treated as time-to-event outcome,...
Introduction: HIV stigma affects medication adherence, psychosocial outcomes, and clinical management for youth living with (YLWH). We explored the impact of on research participation, to inform ethical engagement this vulnerable group. Methods: interviewed 40 YLWH, 20 caregivers, 39 subject matter experts (SMEs); transcripts were analyzed by HK EG, emerging themes confirmed JA AC. Results: All categories participants identified impacts YLWH suggesting implementing privacy protections,...
Abstract Introduction Adolescents living with HIV (ALHIV, ages 10–19) experience complex barriers to care engagement. Challenges surrounding status disclosure or non-disclosure adolescents may contribute adolescent disengagement from non-adherence ART. We performed a qualitative study investigate the contribution of challenges care. Methods This was disengaged ALHIV and their caregivers, healthcare workers (HCW) in Academic Model Providing Access Healthcare (AMPATH) program western Kenya....
Background: There are few validated tools to measure stigma, particularly among children living with HIV and their families. Methods: This study was nested within a larger that followed 240 child–caregiver dyads (children aged 10-15 years) at 8 clinics in western Kenya. The stigma instrument administered all 2 time points 6 months apart. primary end point construct validity assessed by comparison criterion constructs using generalized estimating equation models. Results: Mean age of child...
Background: Long-term impact of drug resistance in perinatally infected children and adolescents living with HIV (CALWH) is poorly understood. We determined examined its long-term on failure mortality Kenyan CALWH failing first-line non-nucleoside reverse transcriptase inhibitor–based antiretroviral therapy (ART). Setting: Academic Model Providing Access to Healthcare, western Kenya. Methods: Participants were enrolled 2010–2013 (timepoint 1) a subsample re-enrolled after 4–7 years 2). Viral...
Objective. Interventions that effectively address HIV-related stigma are urgently needed to improve outcomes for adolescents living with HIV (ALHIV). We piloted a series of 4 short narrative films depicting Kenyan ALHIV’s lived experiences and discrimination 57 ALHIV 50 adult caregivers in western Kenya. Methods. Participants completed either pre- post-viewing questionnaires, including an HIV/AIDS-related scale, or participated focus group discussions. Three-month follow-up visits were...
Abstract Introduction Adolescents living with HIV (ALHIV, ages 10–19) have developmentally specific needs in care, and lower retention compared to other age groups. Family‐level contexts may be critical adolescent outcomes, but often been overlooked. We investigated family‐level factors underlying disengagement supporting re‐engagement among adolescents disengaged from care. Methods Semi‐structured interviews were performed 42 ALHIV, 32 of their caregivers 28 healthcare workers (HCW) the...
HIV-1 drug resistance in children and adolescents remains a significant problem countries facing the highest burden of HIV epidemic. Surveillance is an important public health strategy, particularly resource-limited settings, yet, it limited due mostly to cost infrastructure constraints.
Overwhelmed, under-trained medical staff working in resource-limited settings need efficient resources for HIV disclosure counselling. The objective of this study was to describe providers' experiences using tablet computers disclosure-related counselling with HIV-infected children and their caregivers western Kenya, additional perspectives from adolescents. A qualitative design implemented at three clinics Kenya (Bumala, Busia Port Victoria) within the Academic Model Providing Access...
For adolescents living with HIV (ALWH), school may be the most important but understudied social sphere related to stigma. Teachers are role models in classroom and within community, their attitudes behavior towards people have critical psychosocial treatment ramifications. Altering teachers' knowledge, beliefs (K/A/B) about could reduce stigmatizing content teaching, classrooms school, improving environment for ALWH.
Introduction: Understanding community members' knowledge, attitudes, and beliefs about the novel SARS-CoV-2 virus prevalence of associated stigma are critical steps for increasing accurate public health encouraging uptake preventative or mitigating behaviors, ultimately bringing COVID-19 pandemic under control. Methods: We conducted a one-time, phone-based assessment to assess presence perceived reported by Kenyan primary secondary school teachers, as well adolescents living with HIV....
Drug resistance remains a global challenge in children and adolescents living with HIV (CALWH). Characterizing evolution, specifically using next generation sequencing (NGS) can potentially inform care, but understudied, particularly antiretroviral therapy (ART)-experienced CALWH resource-limited settings. We conducted reverse-transcriptase NGS investigated short-and long-term evolution its predicted impact well-characterized cohort of Kenyan failing 1st-line ART followed for up to ~8 years....
Adolescents (10-19 years) living with HIV (ALWH) face unique challenges in controlling long-term, including stigma and perception of within their communities.
HIV stigma is associated with delayed disclosure and worse clinical outcomes for adolescents living (ALWH). Teachers critically influence school environments, but are understudied in terms of stigma. We implemented a school-level, cluster-randomized trial to assess the impact one-day multi-media training on knowledge, attitudes beliefs (K/A/B) teachers western Kenya. Teachers’ K/A/B were evaluated at baseline six months. Additionally, we assessed ALWH enrolled included schools explore...
Background Youth living with HIV perinatal infection spend a lifetime taking antiretroviral treatment (ART) to suppress the virus, and face significant challenges successfully maintaining ART adherence. Tools measure adherence include self-report, medication event monitoring system (MEMS) pill bottle caps, counts, plasma or hair drug levels; however, inter-rater agreement between child caregiver self-report has not been validated in an African setting. This study aims assess self-reports,...
Objective To explore the perspectives of stakeholders on consenting and reconsenting children adolescents living with HIV (CALWH) to participate in research involving biological sampling biobanking. Stakeholders included CALWH, their caregivers, subject matter experts (SMEs) such as Institutional Review Board (IRB) members, Community Advisory (CAB) Healthcare Providers, researchers, community leaders. Study design This qualitative study was conducted at Academic Model Providing Access...