A5052769969- Pharmaceutical studies and practices
- Neonatal Respiratory Health Research
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Neonatal Health and Biochemistry
- Pediatric Pain Management Techniques
- Pharmacological Effects and Toxicity Studies
- Infant Development and Preterm Care
- Anesthesia and Sedative Agents
- Pregnancy and Medication Impact
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- Pharmaceutical Economics and Policy
- Neonatal and fetal brain pathology
- Gastroesophageal reflux and treatments
- Infant Nutrition and Health
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Analytical Methods in Pharmaceuticals
- Pediatric Hepatobiliary Diseases and Treatments
- Epilepsy research and treatment
- Antifungal resistance and susceptibility
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Ethics and Legal Issues in Pediatric Healthcare
University of Utah
2015-2024
Health and Human Development (2HD) Research Network
2014-2016
DePaul University
2015
University of Cincinnati
2014
Children's National
2014
Cincinnati Children's Hospital Medical Center
2014
Texas Tech University
2014
Texas Tech University Health Sciences Center
2014
Erasmus MC - Sophia Children’s Hospital
2014
Primary Children's Hospital
1988-2013
Improvements in neonatal intensive care during the last 20 years have increased survival of most immature newborns at 23 weeks from 0% to 65% some centres, although rates vary widely among centres. University Utah, USA data show that each week utero after raises by 6–9%, 90% 27–28 and 95% 33 weeks. Provision specialised centres provide high‐risk obstetric care, prenatal treatment with corticosteroids, postnatal surfactant nitric oxide, improvements respirators equipment for extremely infants...
ABSTRACT Fluconazole is being increasingly used to prevent and treat invasive candidiasis in neonates, yet dosing largely empirical due the lack of adequate pharmacokinetic (PK) data. We performed a multicenter population PK study fluconazole 23- 40-week-gestation infants less than 120 days age. developed model using nonlinear mixed effect modeling (NONMEM) with NONMEM algorithm. Covariate effects were predefined evaluated based on estimation precision clinical significance. studied 55 who...
Background: Young infants are susceptible to developmental factors influencing the pharmacokinetics of drugs. Fluconazole is increasingly used prevent and treat invasive candidiasis in infants. Dosing guidance remains empiric variable because limited pharmacokinetic data exist. Methods: Our population model derived from 357 fluconazole plasma concentrations 55 (23–40 week gestation) illustrates expected changes clearance based upon gestational age, postnatal weight, creatinine. We a Monte...
A multicenter, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of intravenous (IV) ibuprofen (L-lysine) for early closure nonsymptomatic patent ductus arteriosus (PDA) within 72 hours birth in extremely low-birth-weight (ELBW) infants with evidence ductal shunting by echocardiogram. Eleven sites enrolled 136 PDA (gestational age < 30 weeks; body weight 500 1000 g) receive a 3-day course (10 mg/kg, 5 mg/kg) IV ( N = 68) or placebo 68)....
The lack of methadone pharmacokinetic data in children and neonates restrains dosing to achieve the target concentration these populations. A minimum effective analgesic opioid naïve adults is 0.058 mg·l(-1) , while no withdrawal symptoms were observed suffering if plasma concentrations above 0.06 . racemate which commonly used pediatric anesthetic care metabolized 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) 2-ethyl-5-methyl-3,3-diphenylpyrroline (EMDP).Data from four studies...
This report updates previous CDC guidelines and recommendations on preferred prevention treatment regimens regarding naturally occurring anthrax.Also provided are a wide range of alternative to first-line antimicrobial drugs for use if patients have contraindications or intolerances after wide-area aerosol release Bacillus anthracis spores resources become limited multidrug-resistant B. strain is used (Hendricks KA, Wright ME, Shadomy SV, et al.;
Objective. Systemic oxygenation is improved by inhaled nitric oxide therapy in some newborns with respiratory failure and pulmonary hypertension. Our results were reviewed to determine factors associated an acute improvement systemic oxygenation. Methods. Newborns indices of 25 40 prospectively randomized receive conventional or without 20 ppm oxide. All greater than treated Hemodynamic, blood gas, Doppler ultrasound measurements performed before after 30 60 minutes observation therapy. The...
Asthma is one of the most prevalent diseases in world, for which mainstay treatment has been inhaled glucocorticoids (GCs). Despite widespread use these drugs, approximately 30% asthma sufferers exhibit some degree steroid insensitivity or are refractory to GCs. One hypothesis explain this phenomenon interpatient variability clearance compounds. The objective research determine how metabolism GCs by CYP3A family enzymes could affect their effectiveness asthmatic patients. In work, four...
Critically ill newborns in neonatal intensive care units (NICUs) are at greater risk of developing adverse drug reactions (ADRs). Differentiation ADRs from associated with organ dysfunction/immaturity is difficult. Current ADR algorithm scoring was established arbitrarily without validation infants. The study objective to develop a valid and reliable identify the NICU. Algorithm development began 24-item questionnaire for data collection on 100 previously suspected ADRs. Five pediatric...
Background. Intra-abdominal infections are common in young infants and lead to significant morbidity mortality. Meropenem is a broad-spectrum antimicrobial with excellent activity against pathogens associated intra-abdominal infections. The purpose of this study was determine the safety effectiveness meropenem suspected or complicated
Background Assessment of the seriousness, expectedness and causality are necessary for any adverse event (AE) in a clinical trial. In addition, assessing AE severity helps determine importance setting. Standardisation criteria could make safety information more reliable comparable across trials. Although standardised scales have been developed other research fields, they not suitable use neonates. The development an scale to facilitate conduct interpretation neonatal trials is therefore...
Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated the pathogenesis of asthma. Our hypothesis was that particulate materials via a mechanism distinct from chemical agonists that, cohort children with asthma living location prone to high levels air pollution, expression uniquely sensitive forms may correlate reduced control. Variant were constructed by mutating residues known...
Background: Mycophenolic acid (MPA) exposure in pediatric patients with kidney transplant receiving body surface area (BSA)–based dosing exhibits large variability. Several genetic variants glucuronosyltransferases (UGTs) and of multidrug resistance–associated protein 2 (MRP2) have independently been suggested to predict MPA adult varying results. Here, the combined contribution these pharmacokinetic variability was investigated renal recipients who were on mycophenolic mofetil maintenance...
ALTHOUGH numerous reviews of bacterial meningitis1 , 2 and viral meningitis3 4 have been published within the past decade, no case meningitis has come to our attention in which both a bacterium virus isolated from cerebrospinal fluid. The purpose this report is twofold: such case; present laboratory data indicating that double infection did not occur 148 other patients with whose fluid was examined for bacteria viruses.Case ReportA 10-month-old girl mongolism (C.H.L.A. 205881) admitted...