A5006266245- Pharmaceutical studies and practices
- Neonatal Respiratory Health Research
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Sedative Agents
- Neonatal Health and Biochemistry
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Congenital Heart Disease Studies
- Adrenal Hormones and Disorders
- Renal function and acid-base balance
- Prenatal Substance Exposure Effects
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
- Cardiovascular Conditions and Treatments
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Neonatal and Maternal Infections
- Infant Development and Preterm Care
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Veterinary Pharmacology and Anesthesia
University of Michigan
2014-2023
Center for Drug Evaluation and Research
2021-2023
United States Food and Drug Administration
2021-2023
Michigan Medicine
2002-2021
Research Network (United States)
2020
Health and Human Development (2HD) Research Network
2020
C. S. Mott Children's Hospital
2012-2019
St. John Hospital & Medical Center
2018
University of Toledo Medical Center
2017
Perinatal Institute
2012
Suspected or complicated intra-abdominal infections are common in young infants and lead to significant morbidity mortality. Meropenem is a broad-spectrum antimicrobial agent with excellent activity against pathogens associated this population. The purpose of study was determine the pharmacokinetics (PK) meropenem as basis for optimizing dosing minimizing adverse events.Premature term <91 days old hospitalized 24 neonatal intensive care units were studied. Limited PK sampling performed...
Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality neurodevelopmental disability, treatment is largely guided by physician preference tradition, due to lack of data from well-designed clinical trials. There increasing interest conducting trials novel drugs treat neonatal seizures, but the unique characteristics this disorder patient population require special consideration regard trial design. The Critical Path...
Unplanned extubation (UEX) is a potentially serious complication of mechanical ventilation. Limited information available regarding factors that contribute to UEXs and subsequent reintubation children. We monitored in our pediatric intensive care unit (PICU) for 5-year period assess the incidence patient conditions associated with UEX evaluate whether targeted interventions were reduced rate UEXs.Over period, demographic clinical was collected prospectively on all patients who required an...
The effects of polyvinyl chloride (PVC) tubing and membrane oxygenator (MO) on the concentrations lorazepam morphine in neonatal extracorporeal oxygenation (ECMO) circuit were evaluated using an vitro model that included a closed ECMO with MO, heat exchanger, bladder PVC tubing. was primed blood, electrolytes, albumin heparin maintained at physiologic pH temperature throughout by frequent measurement blood gas probe. Lorazepam each studied separately three separate, but identical circuits...
Phenobarbital is the first-line treatment for neonatal seizures. Many neonates with hypoxic ischemic encephalopathy are treated therapeutic hypothermia, and about 40% have clinical Little known pharmacokinetics of phenobarbital in infants who undergo hypothermia. The objective this study was to determine effect hypothermia on pharmacokinetics, taking into account maturational changes.Level 3 ICU.Infants suspected seizures, all phenobarbital. Some these also received hypothermia.None.A...
Dalbavancin is a novel lipoglycopeptide antibiotic that has potent in vitro activity against Gram-positive microorganisms.
Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP PRN) released an opinion paper 2005 with recommendations for improving the quality quantity pediatric pharmacy education colleges pharmacy, residency programs, fellowships. Although progress has been made increasing availability residencies, there is still much be done meet direct needs patients. purpose this joint outline...
Extracorporeal membrane oxygenation (ECMO) may affect the pharmacokinetics of certain drugs. The objectives this study were to determine (1) gentamicin in neonates on ECMO and compare them reported values for a similar patient population not ECMO, (2) if differ between venous‐venous venous‐arterial bypass, (3) are affected by oxygenator surface area (0.6 m 2 vs 0.8 oxygenators). medical records 29 term who received while reviewed. Data collected included dosage, peak trough serum...
Objective. The purpose of this study was to compare the incidence nephrotoxicity, defined as doubling baseline serum creatinine concentration, in newborn infants with peak vancomycin concentrations ≤40 μg/mL at steady state &gt;40 μg/mL. A secondary objective correlate concomitant disease states and potentially nephrotoxic drug therapy rises recipients. Methods. Newborn culture-provenStaphylococcus aureus or coagulase-negative staphylococcal septicemia who received for &gt;3 days...
Sedation in children poses a great challenge, with the main concern one of safety. The importance providing adequate sedation to was realized only last decade and half, relevant data are severely lacking. Use potent sedative agents is not without risk. Children given wide variety settings by practitioners different degrees experience drugs management adverse effects. Controversial issues must be addressed this area, appropriate tools developed measure individualize treatment based on drugs'...
Preventing significant oxygen desaturation and hypotension through adequate analgesia sedation during nonemergent intubation in neonates is desirable. However, many neonatal intensive care units, elective intubations occur without premedication. There variation the choice of premedication agent(s) doses, an ideal regimen for use has not been developed.To evaluate efficacy algorithm developed neonates.Prospectively collected continuous quality improvement data on a were analyzed following...
The regulatory framework for considering the fetal effects of new drugs is limited. This partially due to fact that pediatric regulations (21 CFR subpart D) do not apply fetus, and only US Health Human Service (HHS) fetus. HHS regulation 45 Part 46 Subpart B limits research approvable by an institutional review board where risk fetus minimal unless holds out prospect a direct benefit or pregnant woman (45 46.204). Research does meet these requirements, but presents opportunity understand,...
A single 30 mg intravenous dose of labetalol given 20 minutes prior to cesarean delivery at 35 weeks gestation for severe pregnancy-induced hypertension was associated with symptoms β-adrenergic blockade (hypoglycemia, bradycardia, hypotension) in preterm twins. The infants were subsequently found have therapeutic concentrations (180 and 150 ng/mL) umbilical cord blood. pharmacology transplacental is reviewed potential mechanisms neonatal are discussed.
We hypothesized that maternal intrapartum antibiotic treatment delays the growth of organism in blood culture obtained during work-up for infants with suspected early-onset sepsis (EOS).Single center, retrospective review culture-proven EOS over 13.5 years period. was defined by isolation a pathogen from within 72 hours birth and ≥ 5 days.Among 81 positive cultures, 38 were deemed to have 43 contaminants. The organisms grown as follows: Escherichia coli 17 infants, Group B streptococcus 10...
Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP PRN) released an opinion paper 2005 with recommendations for improving the quality quantity pediatric pharmacy education colleges pharmacy, residency programs, fellowships. While progress has been made increasing availability residencies, there is still much be done meet direct needs patients. purpose this Joint Opinion...