A5025563144- Skin Protection and Aging
- melanin and skin pigmentation
- Vitamin D Research Studies
- Hair Growth and Disorders
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Skin and Cellular Biology Research
- Wound Healing and Treatments
- Berberine and alkaloids research
- Nasolacrimal Duct Obstruction Treatments
- Apelin-related biomedical research
- Hypertrophic osteoarthropathy and related conditions
- Hippo pathway signaling and YAP/TAZ
- Bioactive Compounds and Antitumor Agents
- Liver physiology and pathology
- Acne and Rosacea Treatments and Effects
- Tryptophan and brain disorders
- Connexins and lens biology
- Medicinal Plants and Bioactive Compounds
- Paraquat toxicity studies and treatments
Chongqing Medical University
2010-2024
Dalian Medical University
2022-2024
Second Affiliated Hospital of Chongqing Medical University
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2009-2023
Stomatology Hospital
2016
Peking University
2016
Harvard University
2014-2016
Massachusetts General Hospital
2014-2016
Alopecia (hair loss) in vitamin D receptor (VDR)-null mice is due to absence of ligand-independent actions the VDR that are required for initiation postmorphogenic hair cycles. Investigations were undertaken determine whether induction signaling pathways play an important role this process. The cWnt and hedgehog target genes characterizes early anagen was found be dramatically attenuated VDR−/− mice, relative wild-type (WT) mice. To reflects impaired responsiveness ligands, vitro studies...
Paraquat (PQ), a widely used herbicide and potent reactive oxygen species (ROS) inducer, can injure multiple tissues organs, especially the lung. However, underlying mechanism is still poorly understood. According to previous reports, neutrophil aggregation excessive ROS production might play pivotal pathogenetic roles. In present study, we found that PQ could prolong lifespan induce generation in concentration-independent manner. Activated nuclear factor-κB (NF-κB), p38 mitogen-activated...
Ligand-dependent actions of the vitamin D receptor (VDR) play a pleiotropic role in regulation innate and adaptive immunity. The liganded VDR is required for recruitment macrophages during inflammatory phase cutaneous wound healing. Although number granulation tissue 2 days after wounding markedly reduced knockout (KO) compared with wild-type mice, ablation does not alter macrophage polarization. Parabiosis studies demonstrate that circulatory chimerism mice unable to rescue defect wounds KO...
The relationship between the active form of vitamin D
Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid that isolated from the Stephania Tetrandra. It known to possess anti-inflammatory and immunomodulatory effects. We have shown TET can effectively suppress production of bacterial lipopolysaccharide (LPS)-induced inflammatory mediators, including cyclooxygenases (COXs), in macrophages. However, whether has an antinociceptive effect on LPS-induced hyperalgesia unknown. In present study, we investigated potential effects mechanisms by which...
Lemon peel can be used as traditional Chinese medicine. Flavonoids are the most important components in lemon peel, which developed natural medicine without side effects. This study investigated protective effect of polyphenols (LPP) on human keratinocyte HaCaT cells under oxidative stress. The active LPP were determined by high performance liquid chromatography. abilities to scavenge DPPH and ABTS+ free radicals studied for detection antioxidation vitro . Cell survival rates MTT assay....
Mice and human patients with impaired vitamin D receptor (VDR) signaling have normal developmental hair growth but display aberrant post-morphogenic cycle progression associated alopecia. In addition, VDR-/- mice exhibit cutaneous wound healing. We undertook experiments to determine whether the stress-inducible regulator of energy homeostasis, DNA damage-inducible transcript 4 (Ddit4), is involved in these processes. By analyzing activation vivo, we show that at day 14 increased Ddit4...
Abstract Cutaneous squamous cell carcinoma ( SCC ) is one of the most common non‐melanoma skin cancers worldwide. While its exact tumorigenesis mechanisms far from well‐established and less satisfied therapeutic strategy can be clinically used nowadays. In this study, we intended to investigate role DNA damage‐inducible transcript 4 DDIT 4) in human . Firstly, identified significantly suppressed tissue cultured A431 line, reduced accelerates keratinocytes proliferation but impedes autophagy...
Axillary bromhidrosis is a condition presenting as malodor caused by an interaction between the discharge of apocrine glands and bacteria. Topical agents, liposuction, elective surgery are currently main therapeutic modalities. However, efficiency these treatments incidences side effects various frequent, depend on patient characteristics, surgical technique, other unknown factors.We report retrospective study outcomes in 396 patients treated mini-incision with subdermal vascular...
Normal interfollicular epidermis (IFE) homeostasis is maintained throughout the entire life by its own stem cells that self-renew and generate progeny undergo terminal differentiation. However, fine markers of in are not well defined yet. Here we found TLR7 identified existence progenitors epidermal murine skin. In vitro, TLR7-expressing comprised two subpopulations were competent to proliferate exhibited distinct differentiation potentials. Three-dimensional (3D) organotypic culture skin...
Vitamin D receptor (VDR) mutations in humans and mice cause alopecia. VDR-null (VDR-/-) exhibit lack of postmorphogenic hair cycles as a result impaired keratinocyte stem cell (KSC) function. To identify the molecular basis for abnormal KSC function, RNA sequencing wild-type (WT) VDR-/- KSCs was performed. These studies demonstrated that >80% differentially expressed genes are up-regulated KSCs; thus, VDR is transcriptional suppressor WT KSCs. Peroxisome proliferator-activated γ (PPARγ),...
The purpose of this study was to observe the effect cloves ( Syzygium aromaticum (L.) Merr. & L.M. Perry) on mouse skin using a UVB‐induced injury model. serum, liver, and indexes mice were determined by kits, H&E tissue staining, qPCR assay. compound composition HPLC. results showed that increased activity Na + ‐K ‐ATPase in then maintained sodium potassium pump damaged muscle membrane. Cloves alleviated oxidative stress induced UVB irradiation normalizing related (T‐SOD, CAT, AGEs,...
Psoriasis affects 2-4% of the population worldwide and its treatment is currently far from satisfactory. Calcipotriol Portulaca oleracea have been reported to exhibit capacity inhibit inflammation in psoriatic patients improve their clinical condition. However, efficacy a combination regimen these two components remains unknown. The aim present study was explore therapeutic P. extract combined with calcipotriol on plaque psoriasis potential mechanism. Eleven were treated humectant containing...
Abstract The cosmetic and functional deformities induced by thickened folds furrows are the main complaints of patients in pachydermoperiostosis (PDP). However, traditional drug therapy only has a limited effect for its unclear genetic pathogenesis. Surgical treatment now become one optimal strategies mainly aiming improvement. Here we describe comprehensive management PDP approached with surgical procedure thereby showing markedly improved outcome. Experientially, is effective may be...
Hypoxia‑related long non‑coding RNAs (lncRNAs) are important indicators of the poor prognosis cancers. The present study aimed to explore potential relationship between melanoma and hypoxia‑related lncRNAs. transcriptome clinical data patients with were downloaded from Cancer Genome Atlas database. prognostic lncRNAs screened out using Pearson's correlation test univariate Cox analysis. As a result, hypoxia‑related‑lncRNA signature based on expression 7 was constructed, one unfavourable...
Rationale: Palmoplantar keratoderma (PPK) is a genetically heterogeneous group of skin diseases, which characterized by erythema and hyperkeratosis. Mal de Meleda (MDM) rare type PPK with an estimated prevalence in the general population 1 100,000. Patient concerns: In this study, we report MDM patient severe lesion flexion contractures fingers toes. Diagnoses: was diagnosed based on clinical manifestations gene test. Interventions: This treated oral acitretin topical tazarotene. Outcomes:...
Autoerythrocyte sensitization syndrome (AES) is a disorder characterized by recurrent, spontaneous, painful bruising in patients with underlying psychosis and neurosis. Its pathogenesis uncertain. Purpuric lesions reproduced injections of washed autologous erythrocytes suggest an autoimmune etiology. The authors described 50-year-old woman who presented recurrent episodes for 8 months, along 2-year history general chronic neurodermatitis. A diagnosis AES was made on the basis clinical...
<title>Abstract</title> Self-organization in organoid morphogenesis involves the coordinated arrangement of interacting cells into higher-order structures, yet underlying principles remain elusive. Here, we investigate how epidermal and dermal respond distinctively to elevated levels hypoxia during skin that largely resembles development embryogenesis. We unveil autonomously generated hypoxic environment-induced metabolic adaptation drives transition from coalesced spheroids a planarized...