A5090927472- Multiple Myeloma Research and Treatments
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- CAR-T cell therapy research
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Reproductive System and Pregnancy
- Fungal Infections and Studies
- Immune Response and Inflammation
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Mast cells and histamine
- RNA Interference and Gene Delivery
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
Inserm
2007-2024
Immunologie et Nouveaux Concepts en Immunothérapie
2023-2024
Nantes Université
2007-2024
Oniris
2023
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2009-2022
Université d'Angers
2020-2021
Centre National de la Recherche Scientifique
2012
Centre de Physiopathologie de Toulouse-Purpan
2007
gammadelta T cells, a major innate-like cell subset, are thought to play in vivo an important role innate and adaptive immune responses various infection agents like parasites, bacteria, or viruses but the mechanisms contributing this process remain ill defined. Owing their ability recognize broad set of microbial molecular patterns, TLRs represent pathway through which pathogens induce dendritic cells (DC) maturation acquisition immunostimulatory functions. In study, we studied effects TLR...
Aging | doi:10.18632/aging.204881. Mélina Georget, Anaïs Defois, Romain Guiho, Nina Bon, Sophie Allain, Cécile Boyer, Boris Halgand, Denis Waast, Gaël Grimandi, Alban Fouasson-Chailloux, Jérôme Guicheux, Claire Vinatier
Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses the chronology inflammation in context blood malignancies. Both diseases are characterized by production a immunoglobulin (mc Ig) which for subsets MGUS MM patients targets pathogens known cause latent infection, major inflammation. Inflammation may influence structure both polyclonal (pc) Ig mc produced malignant plasma cells via sialylation Fc...
Multiple myeloma (MM) remains an incurable plasma cell malignancy. While its origin is enigmatic, association with infectious pathogens including hepatitis C virus (HCV) has been suggested. Here we report nine patients monoclonal gammopathy of undetermined significance (MGUS) or MM previous HCV infection, six whom received antiviral treatment. We studied the evolution disease, according to anti-HCV treatment and antigen specificity purified immunoglobulin, determined using INNO-LIA™ Score...
Inflammatory cytokines play a major role in myeloproliferative neoplasms (MPNs) as regulators of the MPN clone and mediators clinical symptoms complications. Firstly, we investigated effect JAK2V617F on 42 molecules linked to inflammation. For JAK2V617F-mutated patients, allele burden (%JAK2V617F) correlated with levels IL-1β, IL-1Rα, IP-10 leptin polycythemia vera (PV), IL-33 ET; for all other molecules, no correlation was found. Cytokine production also studied human megakaryocytic cell...
Chronic stimulation by infectious or self-antigens initiates subsets of monoclonal gammopathies undetermined significance (MGUS), smoldering multiple myeloma (SMM), (MM). Recently, glucosylsphingosine (GlcSph) was reported to be the target one third immunoglobulins (Igs). In this study 233 patients (137 MGUS, 6 SMM, 90 MM), we analyzed GlcSph-reactivity Igs and non-clonal Igs. The presence GlcSph-reactive in serum unexpectedly frequent, detected for 103/233 (44.2%) patients. However, GlcSph...
Previous studies showed that monoclonal immunoglobulins G (IgGs) of "monoclonal gammopathy undetermined significance" (MGUS) and myeloma were hyposialylated, thus presumably pro-inflammatory, for about half patients, the target IgG was either a virus –Epstein-Barr (EBV), other herpes viruses, hepatitis C (HCV)– or glucolipid, lysoglucosylceramide (LGL1), suggesting antigen-driven disease in these patients. In present study, we show IgAs share characteristics. We collected 35 sera patients...
Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Novel assays such as the multiplex antigen microarray (MIAA) GlcSph assays, permit identification targets for >60% purified immunoglobulins (Igs). Searching additional targets, we selected 28 Igs whose was not represented on MIAA assays; their specificity recognition then analyzed using microarrays consisting...
Subsets of multiple myeloma (MM) and monoclonal gammopathies undetermined significance (MGUS) present with a immunoglobulin specific for hepatitis C virus (HCV), thus are presumably HCV-driven, antiviral treatment can lead to the disappearance antigen stimulation improved control clonal plasma cells. Here we studied role B (HBV) in pathogenesis MGUS MM 45 HBV-infected patients gammopathy. We analysed specificity recognition these patients, validated efficacy (AVT). For 18/45 (40%) target was...
The balance between human innate immune system and Candida albicans virulence signaling mechanisms ultimately dictates the outcome of fungal invasiveness its pathology. To better understand pathophysiology to identify virulence-associated factors in context persistence humans, complex models are indispensable. Although have been extensively studied vitro vivo using different cell subsets lines, it is unclear how C. survives inside tissue granulomas.We developed an original model granuloma,...
Antigenic stimulation initiates subsets of plasma cell dyscrasias, including monoclonal gammopathy undetermined significance (MGUS) and multiple myeloma (MM).1 MGUS MM are characterized by genetically altered clonal cells that produce large quantities a single immunoglobulin (Ig), termed "monoclonal Ig (mcIg)," or M-protein. Smoldering (SMM) is the intermediate stage between asymptomatic MM.2-4 In gammopathies, initial antigenic can be identified studying specificity recognition patient's...
Background: Multiple myeloma remains an incurable plasma cell malignancy. While its origin is enigmatic, association with infectious pathogens including hepatitis C virus (HCV) has been suggested.Methods: We studied thirteen patients monoclonal gammopathy of undetermined significance (MGUS) or multiple previous HCV infection. Viral load was quantified using the VERIS MDx system. The antigen specificity purified immunoglobulins determined INNO-LIA Score, dot-blot assays, and a multiplex...
Cancer therapy utilizing adoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated remarkable clinical outcomes in hematologic malignancies. However, CAR cell application to solid tumors had limited success, partly due the lack tumor-specific antigens and an immune-suppressive tumor microenvironment. From tissues gastric cancer patients, we found that intercellular adhesion molecule 1 (ICAM-1) expression is significantly associated with advanced stage shorter survival. In...